日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

STAT3-Dependent Regulation of CFTR and Ciliogenesis Is Essential for Mucociliary Clearance and Innate Airway Defense in Hyper-IgE Syndrome

STAT3依赖的CFTR和纤毛发生调控对于高IgE综合征中的黏液纤毛清除和先天性气道防御至关重要

Sun, Ling; Walls, Samantha A; Dang, Hong; Quinney, Nancy L; Sears, Patrick R; Sadritabrizi, Taraneh; Hasegawa, Koichi; Okuda, Kenichi; Asakura, Takanori; Chang, Xiuya; Zheng, Meiqi; Mikami, Yu; Dizmond, Felicia U; Danilova, Daniela; Zhou, Lynn; Deshmukh, Anshulika; Cholon, Deborah M; Radicioni, Giorgia; Rogers, Troy D; Kissner, William J; Markovetz, Matthew R; Guhr Lee, Tara N; Gutay, Mark I; Esther, Charles R Jr; Chua, Michael; Grubb, Barbara R; Ehre, Camille; Kesimer, Mehmet; Hill, David B; Ostrowski, Lawrence E; Button, Brian; Gentzsch, Martina; Robinson, Chevalia; Olivier, Kenneth N; Freeman, Alexandra F; Randell, Scott H; Vladar, Eszter; O'Neal, Wanda K; Boucher, Richard C; Chen, Gang

Implications for cystic fibrosis therapy: Potentiator icenticaftor is superior to ivacaftor in improving function and maintaining stability of F508del CFTR

对囊性纤维化治疗的意义:增强剂icenticaftor在改善F508del CFTR的功能和维持其稳定性方面优于ivacaftor。

Cholon, Deborah M; Aleksandrov, Luba A; Quinney, Nancy L; Boyles, Susan E; Jensen, Timothy J; Aleksandrov, Andrei A; Gentzsch, Martina

Cystic fibrosis airway inflammation enables elexacaftor/tezacaftor/ivacaftor-mediated rescue of N1303K CFTR mutation

囊性纤维化气道炎症可使 elexacaftor/tezacaftor/ivacaftor 介导的 N1303K CFTR 突变得到挽救

Gentzsch, Martina; Baker, Brooke; Cholon, Deborah M; Kam, Charissa W; McKinzie, Cameron J; Despotes, Katherine A; Boyles, Susan E; Quinney, Nancy L; Esther, Charles R Jr; Ribeiro, Carla M P

Established and novel human translational models to advance cystic fibrosis research, drug discovery, and optimize CFTR-targeting therapeutics

已建立和新型的人体转化模型,用于推进囊性纤维化研究、药物发现和优化CFTR靶向疗法

Cholon, Deborah M; Gentzsch, Martina

Personalised medicine for non-classic cystic fibrosis resulting from rare CFTR mutations

针对由罕见CFTR基因突变引起的非典型囊性纤维化的个性化医疗

McCravy, Matthew S; Quinney, Nancy L; Cholon, Deborah M; Boyles, Susan E; Jensen, Timothy J; Aleksandrov, Andrei A; Donaldson, Scott H; Noone, Peadar G; Gentzsch, Martina

The cystic fibrosis airway milieu enhances rescue of F508del in a pre-clinical model

囊性纤维化气道环境增强了临床前模型中 F508del 的挽救作用

Gentzsch, Martina; Cholon, Deborah M; Quinney, Nancy L; Boyles, Susan E; Martino, Mary E B; Ribeiro, Carla M P

Recent progress in translational cystic fibrosis research using precision medicine strategies

利用精准医疗策略在囊性纤维化转化研究中取得的最新进展

Cholon, Deborah M; Gentzsch, Martina

Efficacy of lumacaftor-ivacaftor for the treatment of cystic fibrosis patients homozygous for the F508del-CFTR mutation

lumacaftor-ivacaftor 治疗携带 F508del-CFTR 突变纯合子的囊性纤维化患者的疗效

Cholon, Deborah M; Esther, Charles R Jr; Gentzsch, Martina

Immunization with the Haemophilus ducreyi hemoglobin receptor HgbA with adjuvant monophosphoryl lipid A protects swine from a homologous but not a heterologous challenge.

用杜克雷嗜血杆菌血红蛋白受体 HgbA 和佐剂单磷酰脂质 A 进行免疫,可以保护猪免受同源攻击,但不能保护猪免受异源攻击

Fusco William G, Afonina Galyna, Nepluev Igor, Cholon Deborah M, Choudhary Neelima, Routh Patricia A, Almond Glenn W, Orndorff Paul E, Staats Herman, Hobbs Marcia M, Leduc Isabelle, Elkins Christopher

Serial isolates of persistent Haemophilus influenzae in patients with chronic obstructive pulmonary disease express diminishing quantities of the HMW1 and HMW2 adhesins

慢性阻塞性肺疾病患者体内持续存在的流感嗜血杆菌系列分离株中,HMW1 和 HMW2 黏附素的表达量逐渐减少。

Cholon, Deborah M; Cutter, David; Richardson, Stephen K; Sethi, Sanjay; Murphy, Timothy F; Look, Dwight C; St Geme, Joseph W 3rd