日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Highly parallel profiling of the activities and specificities of Cas12a variants in human cells.

对 Cas12a 变体在人类细胞中的活性和特异性进行高度并行分析

Chen Peng, Wu Yankang, Wang Hongjian, Liu Huan, Zhou Jin, Chen Jingli, Lei Jun, Sun Zaiqiao, Paek Chonil, Yin Lei

Engineering of Cas12a nuclease variants with enhanced genome-editing specificity

改造 Cas12a 核酸酶变体,增强基因组编辑特异性

Peng Chen, Jin Zhou, Huan Liu, Erchi Zhou, Boxiao He, Yankang Wu, Hongjian Wang, Zaiqiao Sun, Chonil Paek, Jun Lei, Yongshun Chen, Xinghua Zhang, Lei Yin

Engineering of a compact, high-fidelity EbCas12a variant that can be packaged with its crRNA into an all-in-one AAV vector delivery system

构建一种紧凑、高保真的 EbCas12a 变体,可将其与 crRNA 一起包装到一体化 AAV 载体递送系统中。

Wang, Hongjian; Zhou, Jin; Lei, Jun; Mo, Guosheng; Wu, Yankang; Liu, Huan; Pang, Ziyan; Du, Mingkun; Zhou, Zihao; Paek, Chonil; Sun, Zaiqiao; Chen, Yongshun; Wang, Yan; Chen, Peng; Yin, Lei

High-fidelity CRISPR/Cas12a dual-crRNA screening reveals novel synergistic interactions in hepatocellular carcinoma.

高保真 CRISPR/Cas12a 双 crRNA 筛选揭示肝细胞癌中的新型协同相互作用

Chen Qian, Pang Minhui, Chen Peng, Zhou Zihao, Lei Jun, He Boxiao, Sun Zaiqiao, Paek Chonil, Jing Baowei, Wu Yankang, Liu Shiqi, Chen Yongshun, Yin Lei

Aspirin induces immunogenic cell death and enhances cancer immunotherapy in colorectal cancer

阿司匹林诱导免疫原性细胞死亡并增强结直肠癌的癌症免疫治疗

Jun Lei, Zihao Zhou, Jialing Fang, Zaiqiao Sun, Mengting He, Boxiao He, Qian Chen, Chonil Paek, Peng Chen, Jin Zhou, Hongjian Wang, Mingliang Tang, Lei Yin, Yongshun Chen

Structural basis of the TCR-pHLA complex provides insights into the unconventional recognition of CDR3β in TCR cross-reactivity and alloreactivity

TCR-pHLA复合物的结构基础为理解TCR交叉反应性和同种异体反应性中CDR3β的非常规识别提供了新的见解

San, Dan; Lei, Jun; Liu, Yang; Jing, Baowei; Ye, Xiang; Wei, Pengcheng; Paek, Chonil; Yang, Yi; Zhou, Jin; Chen, Peng; Wang, Hongjian; Chen, Yongshun; Yin, Lei

Cas12a variants designed for lower genome-wide off-target effect through stringent PAM recognition

Cas12a 变体旨在通过严格的 PAM 识别降低全基因组脱靶效应

Jin Zhou, Peng Chen, Hongjian Wang, Huan Liu, Yongzheng Li, Youpeng Zhang, Yankang Wu, Chonil Paek, Zaiqiao Sun, Jun Lei, Lei Yin

Structural Basis for Unusual TCR CDR3β Usage Against an Immunodominant HIV-1 Gag Protein Peptide Restricted to an HLA-B*81:01 Molecule

针对HLA-B*81:01分子限制的免疫优势HIV-1 Gag蛋白肽段的异常TCR CDR3β使用的结构基础

Liu, Yang; Lei, Jun; San, Dan; Yang, Yi; Paek, Chonil; Xia, Zixiong; Chen, Yongshun; Yin, Lei