日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The oral selective estrogen receptor degrader GDC-0810 (ARN-810) in postmenopausal women with hormone receptor-positive HER2-negative (HR + /HER2 -) advanced/metastatic breast cancer

口服选择性雌激素受体降解剂 GDC-0810 (ARN-810) 用于治疗绝经后激素受体阳性/HER2阴性 (HR+/HER2-) 晚期/转移性乳腺癌

Bardia, Aditya; Mayer, Ingrid; Winer, Eric; Linden, Hannah M; Ma, Cynthia X; Parker, Barbara A; Bellet, Meritxell; Arteaga, Carlos L; Cheeti, Sravanthi; Gates, Mary; Chang, Ching-Wei; Fredrickson, Jill; Spoerke, Jill M; Moore, Heather M; Giltnane, Jennifer; Friedman, Lori S; Chow Maneval, Edna; Chan, Iris; Jhaveri, Komal

Entrectinib dose confirmation in pediatric oncology patients: pharmacokinetic considerations

儿童肿瘤患者恩曲替尼剂量确认:药代动力学考量

Meneses-Lorente, Georgina; Guerini, Elena; Mercier, Francois; Parrott, Neil; Kowalski, Karey; Chow-Maneval, Edna; Buchheit, Vincent; Bergthold, Guillaume; Fox, Elizabeth; Phipps, Alex; Djebli, Nassim

Entrectinib in children and young adults with solid or primary CNS tumors harboring NTRK, ROS1, or ALK aberrations (STARTRK-NG)

恩曲替尼用于治疗携带 NTRK、ROS1 或 ALK 异常的实体瘤或原发性中枢神经系统肿瘤的儿童和青少年(STARTRK-NG)

Desai, Ami V; Robinson, Giles W; Gauvain, Karen; Basu, Ellen M; Macy, Margaret E; Maese, Luke; Whipple, Nicholas S; Sabnis, Amit J; Foster, Jennifer H; Shusterman, Suzanne; Yoon, Janet; Weiss, Brian D; Abdelbaki, Mohamed S; Armstrong, Amy E; Cash, Thomas; Pratilas, Christine A; Corradini, Nadège; Marshall, Lynley V; Farid-Kapadia, Mufiza; Chohan, Saibah; Devlin, Clare; Meneses-Lorente, Georgina; Cardenas, Alison; Hutchinson, Katherine E; Bergthold, Guillaume; Caron, Hubert; Chow Maneval, Edna; Gajjar, Amar; Fox, Elizabeth

In vitro and clinical investigations to determine the drug-drug interaction potential of entrectinib, a small molecule inhibitor of neurotrophic tyrosine receptor kinase (NTRK)

体外和临床研究旨在确定恩曲替尼(一种神经营养酪氨酸受体激酶 (NTRK) 小分子抑制剂)的药物相互作用潜力。

Meneses-Lorente, Georgina; Fowler, Stephen; Guerini, Elena; Kowalski, Karey; Chow-Maneval, Edna; Yu, Li; Mercier, Francois; Ullah, Mohammed; Umehara, Kenichi; Brink, Andreas; Buchheit, Vincent; Zwanziger, Elke; Phipps, Alex; Djebli, Nassim

Characterization of the pharmacokinetics of entrectinib and its active M5 metabolite in healthy volunteers and patients with solid tumors

对健康志愿者和实体瘤患者体内恩曲替尼及其活性代谢物M5的药代动力学特征进行研究

Meneses-Lorente, Georgina; Bentley, Darren; Guerini, Elena; Kowalski, Karey; Chow-Maneval, Edna; Yu, Li; Brink, Andreas; Djebli, Nassim; Mercier, Francois; Buchheit, Vincent; Phipps, Alex

Entrectinib in patients with advanced or metastatic NTRK fusion-positive solid tumours: integrated analysis of three phase 1-2 trials

恩曲替尼治疗晚期或转移性 NTRK 融合阳性实体瘤患者:三项 1/2 期试验的综合分析

Doebele, Robert C; Drilon, Alexander; Paz-Ares, Luis; Siena, Salvatore; Shaw, Alice T; Farago, Anna F; Blakely, Collin M; Seto, Takashi; Cho, Byung Chul; Tosi, Diego; Besse, Benjamin; Chawla, Sant P; Bazhenova, Lyudmila; Krauss, John C; Chae, Young Kwang; Barve, Minal; Garrido-Laguna, Ignacio; Liu, Stephen V; Conkling, Paul; John, Thomas; Fakih, Marwan; Sigal, Darren; Loong, Herbert H; Buchschacher, Gary L Jr; Garrido, Pilar; Nieva, Jorge; Steuer, Conor; Overbeck, Tobias R; Bowles, Daniel W; Fox, Elizabeth; Riehl, Todd; Chow-Maneval, Edna; Simmons, Brian; Cui, Na; Johnson, Ann; Eng, Susan; Wilson, Timothy R; Demetri, George D

Entrectinib in ROS1 fusion-positive non-small-cell lung cancer: integrated analysis of three phase 1-2 trials

恩曲替尼治疗 ROS1 融合阳性非小细胞肺癌:三项 1/2 期试验的综合分析

Drilon, Alexander; Siena, Salvatore; Dziadziuszko, Rafal; Barlesi, Fabrice; Krebs, Matthew G; Shaw, Alice T; de Braud, Filippo; Rolfo, Christian; Ahn, Myung-Ju; Wolf, Jürgen; Seto, Takashi; Cho, Byoung Chul; Patel, Manish R; Chiu, Chao-Hua; John, Thomas; Goto, Koichi; Karapetis, Christos S; Arkenau, Hendrick-Tobias; Kim, Sang-We; Ohe, Yuichiro; Li, Yu-Chung; Chae, Young K; Chung, Christine H; Otterson, Gregory A; Murakami, Haruyasu; Lin, Chia-Chi; Tan, Daniel S W; Prenen, Hans; Riehl, Todd; Chow-Maneval, Edna; Simmons, Brian; Cui, Na; Johnson, Ann; Eng, Susan; Wilson, Timothy R; Doebele, Robert C

ALK Inhibitor Response in Melanomas Expressing EML4-ALK Fusions and Alternate ALK Isoforms

表达EML4-ALK融合基因和替代ALK亚型的黑色素瘤对ALK抑制剂的反应

Kasey L Couts ,Judson Bemis ,Jacqueline A Turner ,Stacey M Bagby ,Danielle Murphy ,Jason Christiansen ,Jennifer D Hintzsche ,Anh Le ,Todd M Pitts ,Keith Wells ,Allison Applegate ,Carol Amato ,Pratik Multani ,Edna Chow-Maneval ,John J Tentler ,Yiqun G Shellman ,Matthew J Rioth ,Aik-Choon Tan ,Rene Gonzalez ,Theresa Medina ,Robert C Doebele ,William A Robinson

Androgen receptor mutations in patients with castration-resistant prostate cancer treated with apalutamide

接受阿帕鲁胺治疗的去势抵抗性前列腺癌患者的雄激素受体突变

Rathkopf, D E; Smith, M R; Ryan, C J; Berry, W R; Shore, N D; Liu, G; Higano, C S; Alumkal, J J; Hauke, R; Tutrone, R F; Saleh, M; Chow Maneval, E; Thomas, S; Ricci, D S; Yu, M K; de Boer, C J; Trinh, A; Kheoh, T; Bandekar, R; Scher, H I; Antonarakis, E S

Safety and Antitumor Activity of the Multitargeted Pan-TRK, ROS1, and ALK Inhibitor Entrectinib: Combined Results from Two Phase I Trials (ALKA-372-001 and STARTRK-1)

多靶点泛TRK、ROS1和ALK抑制剂恩曲替尼的安全性和抗肿瘤活性:两项I期试验(ALKA-372-001和STARTRK-1)的综合结果

Drilon, Alexander; Siena, Salvatore; Ou, Sai-Hong Ignatius; Patel, Manish; Ahn, Myung Ju; Lee, Jeeyun; Bauer, Todd M; Farago, Anna F; Wheler, Jennifer J; Liu, Stephen V; Doebele, Robert; Giannetta, Laura; Cerea, Giulio; Marrapese, Giovanna; Schirru, Michele; Amatu, Alessio; Bencardino, Katia; Palmeri, Laura; Sartore-Bianchi, Andrea; Vanzulli, Angelo; Cresta, Sara; Damian, Silvia; Duca, Matteo; Ardini, Elena; Li, Gang; Christiansen, Jason; Kowalski, Karey; Johnson, Ann D; Patel, Rupal; Luo, David; Chow-Maneval, Edna; Hornby, Zachary; Multani, Pratik S; Shaw, Alice T; De Braud, Filippo G