日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

BRD4 modulator ZL0580 and LEDGINs additively block and lock HIV-1 transcription.

BRD4 调节剂 ZL0580 和 LEDGINs 可叠加地阻断和锁定 HIV-1 转录

Pellaers Eline, Janssens Julie, Wils Lore, Denis Alexe, Bhat Anayat, Van Belle Siska, Feng Da, Christ Frauke, Zhan Peng, Debyser Zeger

GS-9822, a preclinical LEDGIN candidate, displays a block-and-lock phenotype in cell culture

GS-9822 是一种 LEDGIN 临床前候选药物,在细胞培养中表现出阻滞和锁定表型。

Bruggemans, Anne; Vansant, Gerlinde; Balakrishnan, Mini; Mitchell, Michael L; Cai, Ruby; Christ, Frauke; Debyser, Zeger

Determinants of Retroviral Integration and Implications for Gene Therapeutic MLV-Based Vectors and for a Cure for HIV-1 Infection

逆转录病毒整合的决定因素及其对基于MLV的基因治疗载体和HIV-1感染治愈的意义

Pellaers, Eline; Bhat, Anayat; Christ, Frauke; Debyser, Zeger

Phage Display-Directed Discovery of LEDGF/p75 Binding Cyclic Peptide Inhibitors of HIV Replication

利用噬菌体展示技术发现抑制HIV复制的LEDGF/p75结合环肽抑制剂

Desimmie, Belete A; Humbert, Michael; Lescrinier, Eveline; Hendrix, Jelle; Vets, Sofie; Gijsbers, Rik; Ruprecht, Ruth M; Dietrich, Ursula; Debyser, Zeger; Christ, Frauke

Towards a Functional Cure of HIV-1: Insight Into the Chromatin Landscape of the Provirus

迈向HIV-1功能性治愈:深入了解前病毒的染色质图谱

Janssens, Julie; Bruggemans, Anne; Christ, Frauke; Debyser, Zeger

Memoriam for Renaud Mahieux

悼念雷诺·马厄

Desimmie, Belete Ayele; Schrijvers, Rik; Demeulemeester, Jonas; Borrenberghs, Doortje; Weydert, Caroline; Thys, Wannes; Vets, Sofie; Van Remoortel, Barbara; Hofkens, Johan; De Rijck, Jan; Hendrix, Jelle; Bannert, Norbert; Gijsbers, Rik; Christ, Frauke; Debyser, Zeger; Kashanchi, Fatah; Bazarbachi, Ali; Gessain, Antoine

Correction: LEDGF/p75-Independent HIV-1 Replication Demonstrates a Role for HRP-2 and Remains Sensitive to Inhibition by LEDGINs

更正:LEDGF/p75非依赖性HIV-1复制表明HRP-2发挥作用,且仍对LEDGINs抑制敏感

Schrijvers, Rik; Rijck, Jan De; Demeulemeester, Jonas; Adachi, Noritaka; Vets, Sofie; Ronen, Keshet; Christ, Frauke; Bushman, Frederic D; Debyser, Zeger; Gijsbers, Rik

Identification of Novel 3-Hydroxy-pyran-4-One Derivatives as Potent HIV-1 Integrase Inhibitors Using in silico Structure-Based Combinatorial Library Design Approach

利用计算机模拟结构组合文库设计方法鉴定新型3-羟基吡喃-4-酮衍生物作为强效HIV-1整合酶抑制剂

Sirous, Hajar; Chemi, Giulia; Gemma, Sandra; Butini, Stefania; Debyser, Zeger; Christ, Frauke; Saghaie, Lotfollah; Brogi, Simone; Fassihi, Afshin; Campiani, Giuseppe; Brindisi, Margherita

Insight in HIV Integration Site Selection Provides a Block-and-Lock Strategy for a Functional Cure of HIV Infection

对艾滋病毒整合位点选择的深入研究为艾滋病毒感染的功能性治愈提供了一种阻断锁定策略

Debyser, Zeger; Vansant, Gerlinde; Bruggemans, Anne; Janssens, Julie; Christ, Frauke

Insight into HIV-2 latency may disclose strategies for a cure for HIV-1 infection

深入了解 HIV-2 潜伏期可能有助于找到治愈 HIV-1 感染的策略

Saleh, Suha; Vranckx, Lenard; Gijsbers, Rik; Christ, Frauke; Debyser, Zeger