日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Deletion of Abi3/Gngt2 influences age-progressive amyloid β and tau pathologies in distinctive ways

Abi3/Gngt2 的缺失以独特的方式影响年龄渐进性的淀粉样蛋白 β 和 tau 病理

Kristen R Ibanez, Karen N McFarland, Jennifer Phillips, Mariet Allen, Christian B Lessard, Lillian Zobel, Elsa Gonzalez De La Cruz, Shivani Shah, Quan Vo, Xue Wang, Zachary Quicksall, Daniel Ryu, Cory Funk, Nilüfer Ertekin-Taner, Stefan Prokop, Todd E Golde, Paramita Chakrabarty

Photodynamic studies reveal rapid formation and appreciable turnover of tau inclusions

光动力学研究揭示了 tau 内含物的快速形成和显著的周转

Cara L Croft, Marshall S Goodwin, Daniel H Ryu, Christian B Lessard, Giancarlo Tejeda, Marc Marrero, Ava R Vause, Giavanna Paterno, Pedro E Cruz, Jada Lewis, Benoit I Giasson, Todd E Golde

γ-Secretase modulators exhibit selectivity for modulation of APP cleavage but inverse γ-secretase modulators do not

γ-分泌酶调节剂对 APP 裂解的调节具有选择性,但逆 γ-分泌酶调节剂则没有

Christian B Lessard, Edgardo Rodriguez, Thomas B Ladd, Lisa M Minter, Barbara A Osborne, Lucio Miele, Todd E Golde, Yong Ran

Alzheimer's disease phospholipase C-gamma-2 (PLCG2) protective variant is a functional hypermorph

阿尔茨海默病磷脂酶 C-γ-2 (PLCG2) 保护性变体是一种功能性超变体

Lorenza Magno, Christian B Lessard, Marta Martins, Verena Lang, Pedro Cruz, Yasmine Asi, Matilda Katan, Jamie Bilsland, Tammaryn Lashley, Paramita Chakrabarty, Todd E Golde, Paul J Whiting

Individual and combined presenilin 1 and 2 knockouts reveal that both have highly overlapping functions in HEK293T cells

单独和联合敲除早老素 1 和 2 表明两者在 HEK293T 细胞中具有高度重叠的功能

Christian B Lessard, Edgardo Rodriguez, Thomas B Ladd, Lisa M Minter, Barbara A Osborne, Lucio Miele, Todd E Golde, Yong Ran

γ-Secretase inhibitors in cancer clinical trials are pharmacologically and functionally distinct

癌症临床试验中的 γ-分泌酶抑制剂在药理学和功能上存在差异

Yong Ran, Fokhrul Hossain, Antonio Pannuti, Christian B Lessard, Gabriela Z Ladd, Joo In Jung, Lisa M Minter, Barbara A Osborne, Lucio Miele, Todd E Golde

γ-Secretase Modulators and APH1 Isoforms Modulate γ-Secretase Cleavage but Not Position of ε-Cleavage of the Amyloid Precursor Protein (APP)

γ-分泌酶调节剂和 APH1 同工型调节 γ-分泌酶裂解但不调节淀粉样前体蛋白 (APP) ε-裂解的位置

Christian B Lessard, Barbara A Cottrell, Hiroko Maruyama, Suraj Suresh, Todd E Golde, Edward H Koo

Substrate sequence influences γ-secretase modulator activity, role of the transmembrane domain of the amyloid precursor protein

底物序列影响 γ-分泌酶调节剂活性、淀粉样蛋白前体跨膜结构域的作用

Sarah A Sagi, Christian B Lessard, Kellen D Winden, Hiroko Maruyama, Jeremy C Koo, Sascha Weggen, Thomas L Kukar, Todd E Golde, Edward H Koo