日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

FOXO1 links KRAS G12D and G12V alleles to glutamine and nitrogen metabolism in colorectal cancer

FOXO1 将 KRAS G12D 和 G12V 等位基因与结直肠癌中的谷氨酰胺和氮代谢联系起来

Suzan Ber,Ming Yang,Marco Sciacovelli,Shamith Samarajiwa,Khushali Patel,Efterpi Nikitopoulou,Annie Howitt,Simon J Cook,Ashok R Venkitaraman  ,Christian Frezza    ,Alessandro Esposito

Mitochondrial metabolism sustains DNMT3A-R882-mutant clonal haematopoiesis

线粒体代谢维持DNMT3A-R882突变克隆性造血

Malgorzata Gozdecka ,Monika Dudek # ,Sean Wen # ,Muxin Gu ,Richard J Stopforth ,Justyna Rak ,Aristi Damaskou ,Guinevere L Grice ,Matthew A McLoughlin ,Laura Bond ,Rachael Wilson ,George Giotopoulos ,Vijaya Mahalingam Shanmugiah ,Rula Bany Bakar ,Eliza Yankova ,Jonathan L Cooper ,Nisha Narayan ,Sarah J Horton ,Ryan Asby ,Dean C Pask ,Annalisa Mupo ,Graham Duddy ,Ludovica Marando ,Theodoros Georgomanolis ,Paul Carter ,Amirtha Priya Ramesh ,William G Dunn ,Clea Barcena ,Paolo Gallipoli ,Kosuke Yusa ,Slavé Petrovski ,Penny Wright ,Pedro M Quiros ,Christian Frezza ,James A Nathan ,Arthur Kaser ,Siddhartha Kar ,Konstantinos Tzelepis ,Jonathan Mitchell ,Margarete A Fabre ,Brian J P Huntly ,George S Vassiliou

Cytidine diphosphate diacylglycerol synthase 2 is a synthetic lethal target in mesenchymal-like cancers

胞苷二磷酸二酰甘油合酶2是间质样癌症中的合成致死靶点

Tim Arnoldus ,Alex van Vliet ,Onno B Bleijerveld ,Adriaan F H de Groot ,Qinglin Piao ,Niek Blomberg ,Désirée Schatton ,Jing Dong ,Susan E van Hal-van Veen ,Rolf Harkes ,Anita E Grootemaat ,Natalie Proost ,Birol Cabukusta ,Christian Frezza ,Marieke van de Ven ,Nicole N van der Wel ,Martin Giera ,Maarten Altelaar ,Daniel S Peeper

Autophagy regulator ATG5 preserves cerebellar function by safeguarding its glycolytic activity

自噬调节剂 ATG5 通过保护小脑的糖酵解活性来维持小脑功能

Janine Tutas, Marianna Tolve, Ebru Özer-Yildiz, Lotte Ickert, Ines Klein, Quinn Silverman, Filip Liebsch, Frederik Dethloff, Patrick Giavalisco, Heike Endepols, Theodoros Georgomanolis, Bernd Neumaier, Alexander Drzezga, Guenter Schwarz, Bernard Thorens, Graziana Gatto, Christian Frezza, Natalia L K

Pro-inflammatory macrophages produce mitochondria-derived superoxide by reverse electron transport at complex I that regulates IL-1β release during NLRP3 inflammasome activation

促炎巨噬细胞通过复合物 I 的逆向电子传递产生线粒体来源的超氧化物,该超氧化物在 NLRP3 炎症小体激活过程中调节 IL-1β 的释放。

Alva M Casey ,Dylan G Ryan ,Hiran A Prag ,Suvagata Roy Chowdhury ,Eloïse Marques ,Keira Turner ,Anja V Gruszczyk ,Ming Yang ,Dane M Wolf ,Jan Lj Miljkovic ,Joyce Valadares ,Patrick F Chinnery ,Richard C Hartley ,Christian Frezza ,Julien Prudent ,Michael P Murphy

An atlas of ferroptosis-induced secretomes

铁死亡诱导分泌组的图谱

F Isil Yapici ,Eric Seidel ,Alina Dahlhaus ,Josephine Weber ,Christina Schmidt ,Adriano de Britto Chaves Filho ,Ming Yang ,Maria Nenchova ,Emre Güngör ,Jenny Stroh ,Ioanna Kotouza ,Julia Beck ,Ali T Abdallah ,Jan-Wilm Lackmann ,Christina M Bebber ,Ariadne Androulidaki ,Peter Kreuzaler ,Almut Schulze ,Christian Frezza ,Silvia von Karstedt

Organismal metabolism regulates the expansion of oncogenic PIK3CA mutant clones in normal esophagus

机体代谢调节正常食管中致癌性PIK3CA突变克隆的扩增

Albert Herms # ,Bartomeu Colom # ,Gabriel Piedrafita ,Argyro Kalogeropoulou ,Ujjwal Banerjee ,Charlotte King ,Emilie Abby ,Kasumi Murai ,Irene Caseda ,David Fernandez-Antoran ,Swee Hoe Ong ,Michael W J Hall ,Christopher Bryant ,Roshan K Sood ,Joanna C Fowler ,Albert Pol ,Christian Frezza ,Bart Vanhaesebroeck ,Philip H Jones

Raman micro-spectroscopy reveals the spatial distribution of fumarate in cells and tissues

拉曼显微光谱揭示富马酸在细胞和组织中的空间分布

Marlous Kamp, Jakub Surmacki, Marc Segarra Mondejar, Tim Young, Karolina Chrabaszcz, Fadwa Joud, Vincent Zecchini, Alyson Speed, Christian Frezza, Sarah E Bohndiek

Inhibition of asparagine synthetase effectively retards polycystic kidney disease progression

抑制天冬酰胺合成酶可有效延缓多囊肾病进展

Sara Clerici #, Christine Podrini #, Davide Stefanoni, Gianfranco Distefano, Laura Cassina, Maria Elena Steidl, Laura Tronci, Tamara Canu, Marco Chiaravalli, Daniel Spies, Thomas A Bell 3rd, Ana Sh Costa, Antonio Esposito, Angelo D'Alessandro, Christian Frezza, Angela Bachi, Alessandra Boletta

Macrophage fumarate hydratase restrains mtRNA-mediated interferon production

巨噬细胞富马酸水合酶抑制线粒体RNA介导的干扰素产生

Alexander Hooftman # ,Christian G Peace # ,Dylan G Ryan # ,Emily A Day ,Ming Yang ,Anne F McGettrick ,Maureen Yin ,Erica N Montano ,Lihong Huo ,Juliana E Toller-Kawahisa ,Vincent Zecchini ,Tristram A J Ryan ,Alfonso Bolado-Carrancio ,Alva M Casey ,Hiran A Prag ,Ana S H Costa ,Gabriela De Los Santos ,Mariko Ishimori ,Daniel J Wallace ,Swamy Venuturupalli ,Efterpi Nikitopoulou ,Norma Frizzell ,Cecilia Johansson ,Alexander Von Kriegsheim ,Michael P Murphy ,Caroline Jefferies ,Christian Frezza ,Luke A J O'Neill