muO-conotoxin MrVIB selectively blocks Nav1.8 sensory neuron specific sodium channels and chronic pain behavior without motor deficits.
muO-芋螺毒素 MrVIB 选择性阻断 Nav1.8 感觉神经元特异性钠通道,可引起慢性疼痛行为,而不会导致运动功能障碍
期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.0601819103
Ekberg J, Jayamanne A, Vaughan C W, Aslan S, Thomas L, Mould J, Drinkwater R, Baker M D, Abrahamsen B, Wood J N, Adams D J, Christie M J, Lewis R J