日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Huntingtin interactome reveals huntingtin role in regulation of double strand break DNA damage response (DSB/DDR), chromatin remodeling and RNA processing pathways

亨廷顿蛋白相互作用组揭示了亨廷顿蛋白在调节双链断裂 DNA 损伤反应 (DSB/DDR)、染色质重塑和 RNA 加工途径中的作用

Tamara Ratovitski, Chloe D Holland, Robert N O'Meally, Alexey V Shevelkin, Tianze Shi, Robert N Cole, Mali Jiang, Christopher A Ross

Arginine methylation of RNA-binding proteins is impaired in Huntington's disease

亨廷顿氏病中 RNA 结合蛋白的精氨酸甲基化受损

Tamara Ratovitski, Siddhi V Kamath, Robert N O'Meally, Keerthana Gosala, Chloe D Holland, Mali Jiang, Robert N Cole, Christopher A Ross

Interaction of huntingtin with PRMTs and its subsequent arginine methylation affects HTT solubility, phase transition behavior and neuronal toxicity

亨廷顿蛋白与 PRMT 的相互作用及其随后的精氨酸甲基化影响 HTT 溶解度、相变行为和神经元毒性

Tamara Ratovitski, Mali Jiang, Robert N O'Meally, Priyanka Rauniyar, Ekaterine Chighladze, Anikó Faragó, Siddhi V Kamath, Jing Jin, Alexey V Shevelkin, Robert N Cole, Christopher A Ross

Huntingtin silencing delays onset and slows progression of Huntington's disease: a biomarker study

亨廷顿蛋白沉默可延迟亨廷顿病的发病并减缓其进展:一项生物标志物研究

Hongshuai Liu, Chuangchuang Zhang, Jiadi Xu, Jing Jin, Liam Cheng, Xinyuan Miao, Qian Wu, Zhiliang Wei, Peiying Liu, Hanzhang Lu, Peter C M van Zijl, Christopher A Ross, Jun Hua, Wenzhen Duan

Huntingtin-mediated axonal transport requires arginine methylation by PRMT6

亨廷顿蛋白介导的轴突运输需要 PRMT6 进行精氨酸甲基化

Alice Migazzi, Chiara Scaramuzzino, Eric N Anderson, Debasmita Tripathy, Ivó H Hernández, Rogan A Grant, Michela Roccuzzo, Laura Tosatto, Amandine Virlogeux, Chiara Zuccato, Andrea Caricasole, Tamara Ratovitski, Christopher A Ross, Udai B Pandey, José J Lucas, Frédéric Saudou, Maria Pennuto, Manuela

Immortalized striatal precursor neurons from Huntington's disease patient-derived iPS cells as a platform for target identification and screening for experimental therapeutics

以亨廷顿氏病患者来源的 iPS 细胞为原料,构建永生化纹状体前体神经元,作为实验疗法的靶标识别和筛选平台

Sergey S Akimov, Mali Jiang, Amanda J Kedaigle, Nicolas Arbez, Leonard O Marque, Chelsy R Eddings, Paul T Ranum, Emma Whelan, Anthony Tang, Ronald Wang, Lauren R DeVine, Conover C Talbot, Robert N Cole, Tamara Ratovitski, Beverly L Davidson, Ernest Fraenkel, Christopher A Ross

TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models

TBK1 磷酸化突变型亨廷顿蛋白并抑制其在亨廷顿病模型中的聚集和毒性

Ramanath Narayana Hegde, Anass Chiki, Lara Petricca, Paola Martufi, Nicolas Arbez, Laurent Mouchiroud, Johan Auwerx, Christian Landles, Gillian P Bates, Malvindar K Singh-Bains, Mike Dragunow, Maurice A Curtis, Richard Lm Faull, Christopher A Ross, Andrea Caricasole, Hilal A Lashuel

Transmembrane Protein 230 Mediates a Poly(ADP-ribose) Polymerase-1-Linked Apoptosis

跨膜蛋白 230 介导聚(ADP-核糖)聚合酶-1 关联的细胞凋亡

Xiaobo Wang, Tengteng Wu, Jinru Zhang, Gongbo Guo, XiaoFei He, Zhong Pei, Zhaohui Liu, Chun-Feng Liu, Christopher A Ross, Wanli W Smith

Pridopidine protects neurons from mutant-huntingtin toxicity via the sigma-1 receptor

普利多匹定通过 sigma-1 受体保护神经元免受突变型亨廷顿蛋白的毒性

Chelsy R Eddings, Nicolas Arbez, Sergey Akimov, Michal Geva, Michael R Hayden, Christopher A Ross

Physiological and pathological roles of LRRK2 in the nuclear envelope integrity

LRRK2在核膜完整性中的生理和病理作用

Vered Shani ,Hazem Safory ,Raymonde Szargel ,Ninghan Wang ,Tsipora Cohen ,Fatimah Abd Elghani ,Haya Hamza ,Mor Savyon ,Inna Radzishevsky ,Lihi Shaulov ,Ruth Rott ,Kah-Leong Lim ,Christopher A Ross ,Rina Bandopadhyay ,Hui Zhang ,Simone Engelender