日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Effect of benralizumab treatment on the airway microbiome in COPD

贝那利珠单抗治疗对慢性阻塞性肺疾病患者气道微生物组的影响

Haldar, Koirobi; Mistry, Vijay; Richardson, Mathew; Hamblet, Corinne; Jison, Maria; Barer, Michael R; McCrae, Christopher; Brightling, Christopher E

Accelarated immune ageing is associated with COVID-19 disease severity

免疫衰老加速与新冠肺炎病情严重程度相关。

Janet M Lord ,Tonny Veenith ,Jack Sullivan ,Archana Sharma-Oates ,Alex G Richter ,Neil J Greening ,Hamish J C McAuley ,Rachael A Evans ,Paul Moss ,Shona C Moore ,Lance Turtle ,Nandan Gautam ,Ahmed Gilani ,Manan Bajaj ,Louise V Wain ,Christopher Brightling ,Betty Raman ,Michael Marks ,Amisha Singapuri ,Omer Elneima ,Peter J M Openshaw ,Niharika A Duggal

Elevated PLAUR is observed in the airway epithelium of asthma patients and blocking improves barrier integrity

在哮喘患者的气道上皮中观察到 PLAUR 升高,阻断可改善屏障完整性

Michael A Portelli, Sangita Bhaker, Vincent Pang, David O Bates, Simon R Johnson, Andrew P Mazar, Dominick Shaw, Christopher Brightling, Ian Sayers

Defective sirtuin-1 increases IL-4 expression through acetylation of GATA-3 in patients with severe asthma

在重度哮喘患者中,缺陷的 sirtuin-1 通过乙酰化 GATA-3 增加 IL-4 表达

Thomas Colley, Nicolas Mercado, Yuichi Kunori, Christopher Brightling, Pankaj K Bhavsar, Peter J Barnes, Kazuhiro Ito

COPD exacerbation severity and frequency is associated with impaired macrophage efferocytosis of eosinophils

COPD 急性加重的严重程度和频率与巨噬细胞对嗜酸性粒细胞的吞噬作用受损有关

Osama Eltboli, Mona Bafadhel, Fay Hollins, Adam Wright, Beverley Hargadon, Neeta Kulkarni, Christopher Brightling

Functional KCa3.1 channels regulate steroid insensitivity in bronchial smooth muscle cells

功能性 KCa3.1 通道调节支气管平滑肌细胞的类固醇不敏感性

Latifa Chachi, Aarti Shikotra, S Mark Duffy, Omar Tliba, Christopher Brightling, Peter Bradding #, Yassine Amrani #

Mast cell-airway smooth muscle crosstalk: the role of thymic stromal lymphopoietin

肥大细胞-气道平滑肌串扰:胸腺基质淋巴细胞生成素的作用

Davinder Kaur, Camille Doe, Lucy Woodman, Wing-Yan Heidi Wan, Amanda Sutcliffe, Fay Hollins, Christopher Brightling

IL-13 expression by blood T cells and not eosinophils is increased in asthma compared to non-asthmatic eosinophilic bronchitis

与非哮喘性嗜酸性支气管炎相比,哮喘患者血液 T 细胞(而非嗜酸性粒细胞)的 IL-13 表达增加

Salman Siddiqui, Glenn Cruse, Susan McKenna, William Monteiro, Vijay Mistry, Andrew Wardlaw, Christopher Brightling