日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Manufacture of CD22 CAR T cells following positive versus negative selection results in distinct cytokine secretion profiles and γδ T cell output

经过正向和负向选择后,CD22 CAR T 细胞的制造会产生不同的细胞因子分泌特征和 γδ T 细胞输出

Hannah W Song, Mehdi Benzaoui, Alka Dwivedi, Sarah Underwood, Lipei Shao, Sooraj Achar, Vesna Posarac, Victoria A Remley, Michaela Prochazkova, Yihua Cai, Ping Jin, Robert P Somerville, David F Stroncek, Grégoire Altan-Bonnet, Nirali N Shah, Christopher D Chien, Naomi Taylor, Steven L Highfill

Perforin-deficient CAR T cells recapitulate late-onset inflammatory toxicities observed in patients

穿孔素缺陷型 CAR-T 细胞重现患者中观察到的迟发性炎症毒性

Kazusa Ishii, Marie Pouzolles, Christopher D Chien, Rebecca A Erwin-Cohen, M Eric Kohler, Haiying Qin, Haiyan Lei, Skyler Kuhn, Amanda K Ombrello, Alina Dulau-Florea, Michael A Eckhaus, Haneen Shalabi, Bonnie Yates, Daniel A Lichtenstein, Valérie S Zimmermann, Taisuke Kondo, Jack F Shern, Howard A Y

TCR engagement negatively affects CD8 but not CD4 CAR T cell expansion and leukemic clearance

TCR 结合对 CD8 CAR T 细胞扩增和白血病清除有负面影响,但对 CD4 CAR T 细胞扩增和白血病清除无影响

Yinmeng Yang, M Eric Kohler, Christopher D Chien, Christopher T Sauter, Elad Jacoby, Chunhua Yan, Ying Hu, Kelsey Wanhainen, Haiying Qin, Terry J Fry

Murine allogeneic CD19 CAR T cells harbor potent antileukemic activity but have the potential to mediate lethal GVHD

小鼠同种异体 CD19 CAR T 细胞具有强效抗白血病活性,但有可能介导致命的 GVHD

Elad Jacoby, Yinmeng Yang, Haiying Qin, Christopher D Chien, James N Kochenderfer, Terry J Fry

CD19 CAR immune pressure induces B-precursor acute lymphoblastic leukaemia lineage switch exposing inherent leukaemic plasticity

CD19 CAR免疫压力诱导B细胞前体急性淋巴细胞白血病谱系转换,暴露白血病固有可塑性

Elad Jacoby ,Sang M Nguyen ,Thomas J Fountaine ,Kathryn Welp ,Berkley Gryder ,Haiying Qin ,Yinmeng Yang ,Christopher D Chien ,Alix E Seif ,Haiyan Lei ,Young K Song ,Javed Khan ,Daniel W Lee ,Crystal L Mackall ,Rebecca A Gardner ,Michael C Jensen ,Jack F Shern ,Terry J Fry

Regulation of HER2 oncogene transcription by a multifunctional coactivator/corepressor complex

多功能辅激活剂/辅抑制物复合物对 HER2 致癌基因转录的调控

Jason P Garee, Christopher D Chien, Jordan V Li, Anton Wellstein, Anna T Riegel

Transcriptional repression of AIB1 by FoxG1 leads to apoptosis in breast cancer cells

FoxG1 对 AIB1 的转录抑制导致乳腺癌细胞凋亡

Jordan V Li, Christopher D Chien, Jason P Garee, Jianming Xu, Anton Wellstein, Anna T Riegel

Role of the nuclear receptor coactivator AIB1-Delta4 splice variant in the control of gene transcription

核受体辅激活因子 AIB1-Delta4 剪接变体在基因转录控制中的作用

Christopher D Chien, Alexander Kirilyuk, Jordan V Li, Wentao Zhang, Tyler Lahusen, Marcel O Schmidt, Annabell S Oh, Anton Wellstein, Anna T Riegel

Tyrosine phosphorylation of the nuclear receptor coactivator AIB1/SRC-3 is enhanced by Abl kinase and is required for its activity in cancer cells

Abl 激酶增强核受体辅激活因子 AIB1/SRC-3 的酪氨酸磷酸化,这是其在癌细胞中发挥活性所必需的

Annabell S Oh, John T Lahusen, Christopher D Chien, Mark P Fereshteh, Xiaolong Zhang, Sivanesan Dakshanamurthy, Jianming Xu, Benjamin L Kagan, Anton Wellstein, Anna T Riegel