Structural insights into WRN helicase reveal conformational states and opportunities for MSI-H cancer drug discovery
对WRN解旋酶的结构解析揭示了其构象状态,并为MSI-H癌症药物研发提供了契机。
期刊:Communications Biology
影响因子:5.1
doi:10.1038/s42003-026-09584-0
Fletcher, Catherine T; Mornement, Abigail A; Barrett, Charlotte; Canning, Peter; Rucktooa, Prakash; Huber, Sophie; Cooper, Christopher D O; Scully, Conor C G; Doré, Andrew S; Rohle, Daniel; Smith, Geoffrey M T; Skerratt, Sarah E; Kennedy, Amanda J