日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Uridine phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes

尿苷磷酸化酶-1通过改变免疫和细胞外基质环境来促进转移

Declan Whyte ,Sophie L Fisher ,Christopher G J McKenzie ,David Sumpton ,Sandeep Dhayade ,Emmanuel Dornier ,Madeleine Moore ,David Novo ,Jasmine Peters ,Robert Wiesheu ,Michalis D Gounis ,Dale M Watt ,John B G Mackey ,Amanda J McFarlane ,Frédéric Fercoq ,Carolina Dehesa Caballero ,Keara L Redmond ,Louise E Mitchell ,Eve Anderson ,Gemma Thomson ,Ann Hedley ,William Clark ,Shannen Leroi ,Lindsey N Dzierozynski ,Juan J Apiz Saab ,Caroline A Lewis ,Alexander Muir ,Christopher J Halbrook ,Douglas Strathdee ,Rene Jackstadt ,Colin Nixon ,Philip Dunne ,Leo M Carlin ,Iain R Macpherson ,Edward W Roberts ,Seth B Coffelt ,Karen Blyth ,Owen J Sansom ,Jim C Norman ,Johan Vande Voorde ,Cassie J Clarke

CARMIL1-AA selectively inhibits macropinocytosis while sparing autophagy

CARMIL1-AA选择性抑制巨胞饮作用,同时不影响自噬作用

Rebecca M Lim ,Alexa Lu ,Brennan M Chuang ,Cecily Anaraki ,Brandon Chu ,Christopher J Halbrook ,Aimee L Edinger

Malic enzyme 1 knockout has no deleterious phenotype and is favored in the male germline under standard laboratory conditions

苹果酸酶 1 敲除没有有害表型,并且在标准实验室条件下在雄性生殖系中占优势

Jonathan M Alektiar, Mengrou Shan, Megan D Radyk, Li Zhang, Christopher J Halbrook, Lin Lin, Carlos Espinoza, Ivan F Mier, Brooke L Lavoie, Lucie Salvatore, Marina Pasca di Magliano, Lewis C Cantley, Jacob L Mueller, Costas A Lyssiotis

Uridine-derived ribose fuels glucose-restricted pancreatic cancer

尿苷衍生的核糖为葡萄糖受限的胰腺癌提供能量

Zeribe C Nwosu # ,Matthew H Ward # ,Peter Sajjakulnukit # ,Pawan Poudel # ,Chanthirika Ragulan ,Steven Kasperek ,Megan Radyk ,Damien Sutton ,Rosa E Menjivar ,Anthony Andren ,Juan J Apiz-Saab ,Zachary Tolstyka ,Kristee Brown ,Ho-Joon Lee ,Lindsey N Dzierozynski ,Xi He ,Hari Ps ,Julia Ugras ,Gift Nyamundanda ,Li Zhang ,Christopher J Halbrook ,Eileen S Carpenter ,Jiaqi Shi ,Leah P Shriver ,Gary J Patti ,Alexander Muir ,Marina Pasca di Magliano ,Anguraj Sadanandam ,Costas A Lyssiotis

Arginase 1 is a key driver of immune suppression in pancreatic cancer

精氨酸酶 1 是胰腺癌免疫抑制的关键驱动因素

Rosa E Menjivar, Zeribe C Nwosu, Wenting Du, Katelyn L Donahue, Hanna S Hong, Carlos Espinoza, Kristee Brown, Ashley Velez-Delgado, Wei Yan, Fatima Lima, Allison Bischoff, Padma Kadiyala, Daniel Salas-Escabillas, Howard C Crawford, Filip Bednar, Eileen Carpenter, Yaqing Zhang, Christopher J Halbrook

Glucose-6-phosphate dehydrogenase deficiency accelerates pancreatic acinar-to-ductal metaplasia

葡萄糖-6-磷酸脱氢酶缺乏加速胰腺腺泡导管化生

Megan D Radyk, Barbara S Nelson, Christopher J Halbrook, Alexander Wood, Brooke Lavoie, Lucie Salvatore, Gabriel Corfas, Justin A Colacino, Yatrik M Shah, Howard C Crawford, Costas A Lyssiotis

Differential integrated stress response and asparagine production drive symbiosis and therapy resistance of pancreatic adenocarcinoma cells

差异性综合应激反应和天冬酰胺生成驱动胰腺腺癌细胞的共生和治疗耐药性

Christopher J Halbrook, Galloway Thurston, Seth Boyer, Cecily Anaraki, Jennifer A Jiménez, Amy McCarthy, Nina G Steele, Samuel A Kerk, Hanna S Hong, Lin Lin, Fiona V Law, Catherine Felton, Lorenzo Scipioni, Peter Sajjakulnukit, Anthony Andren, Alica K Beutel, Rima Singh, Barbara S Nelson, Fran Van D

Multiomic characterization of pancreatic cancer-associated macrophage polarization reveals deregulated metabolic programs driven by the GM-CSF-PI3K pathway

胰腺癌相关巨噬细胞极化的多组学表征揭示了由 GM-CSF-PI3K 通路驱动的失调代谢程序

Seth Boyer #, Ho-Joon Lee #, Nina Steele, Li Zhang, Peter Sajjakulnukit, Anthony Andren, Matthew H Ward, Rima Singh, Venkatesha Basrur, Yaqing Zhang, Alexey I Nesvizhskii, Marina Pasca di Magliano, Christopher J Halbrook, Costas A Lyssiotis

Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth

天冬酰胺将线粒体呼吸与 ATF4 活性和肿瘤生长联系起来

Abigail S Krall, Peter J Mullen, Felicia Surjono, Milica Momcilovic, Ernst W Schmid, Christopher J Halbrook, Apisadaporn Thambundit, Steven D Mittelman, Costas A Lyssiotis, David B Shackelford, Simon R V Knott, Heather R Christofk

GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis

GOT1抑制剂通过铁死亡促进胰腺癌细胞死亡

Daniel M Kremer ,Barbara S Nelson ,Lin Lin ,Emily L Yarosz ,Christopher J Halbrook ,Samuel A Kerk ,Peter Sajjakulnukit ,Amy Myers ,Galloway Thurston ,Sean W Hou ,Eileen S Carpenter ,Anthony C Andren ,Zeribe C Nwosu ,Nicholas Cusmano ,Stephanie Wisner ,Nneka E Mbah ,Mengrou Shan ,Nupur K Das ,Brian Magnuson ,Andrew C Little ,Milan R Savani ,Johanna Ramos ,Tina Gao ,Stephen A Sastra ,Carmine F Palermo ,Michael A Badgley ,Li Zhang ,John M Asara ,Samuel K McBrayer ,Marina Pasca di Magliano ,Howard C Crawford ,Yatrik M Shah ,Kenneth P Olive ,Costas A Lyssiotis