日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

DrugMap: A quantitative pan-cancer analysis of cysteine ligandability

DrugMap:半胱氨酸配体结合能力的泛癌定量分析

Mariko Takahashi ,Harrison B Chong ,Siwen Zhang ,Tzu-Yi Yang ,Matthew J Lazarov ,Stefan Harry ,Michelle Maynard ,Brendan Hilbert ,Ryan D White ,Heather E Murrey ,Chih-Chiang Tsou ,Kira Vordermark ,Jonathan Assaad ,Magdy Gohar ,Benedikt R Dürr ,Marianne Richter ,Himani Patel ,Gregory Kryukov ,Natasja Brooijmans ,Aliyu Sidi Omar Alghali ,Karla Rubio ,Antonio Villanueva ,Junbing Zhang ,Maolin Ge ,Farah Makram ,Hanna Griesshaber ,Drew Harrison ,Ann-Sophie Koglin ,Samuel Ojeda ,Barbara Karakyriakou ,Alexander Healy ,George Popoola ,Inbal Rachmin ,Neha Khandelwal ,Jason R Neil ,Pei-Chieh Tien ,Nicholas Chen ,Tobias Hosp ,Sanne van den Ouweland ,Toshiro Hara ,Lillian Bussema ,Rui Dong ,Lei Shi ,Martin Q Rasmussen ,Ana Carolina Domingues ,Aleigha Lawless ,Jacy Fang ,Satoshi Yoda ,Linh Phuong Nguyen ,Sarah Marie Reeves ,Farrah Nicole Wakefield ,Adam Acker ,Sarah Elizabeth Clark ,Taronish Dubash ,John Kastanos ,Eugene Oh ,David E Fisher ,Shyamala Maheswaran ,Daniel A Haber ,Genevieve M Boland ,Moshe Sade-Feldman ,Russell W Jenkins ,Aaron N Hata ,Nabeel M Bardeesy ,Mario L Suvà ,Brent R Martin ,Brian B Liau ,Christopher J Ott ,Miguel N Rivera ,Michael S Lawrence ,Liron Bar-Peled

CIC-DUX4 Chromatin Profiling Reveals New Epigenetic Dependencies and Actionable Therapeutic Targets in CIC-Rearranged Sarcomas

CIC-DUX4 染色质分析揭示了 CIC 重排肉瘤中的新表观遗传依赖性和可操作的治疗靶点

Arnaud Bakaric, Luisa Cironi, Viviane Praz, Rajendran Sanalkumar, Liliane C Broye, Kerria Favre-Bulle, Igor Letovanec, Antonia Digklia, Raffaele Renella, Ivan Stamenkovic, Christopher J Ott, Takuro Nakamura, Cristina R Antonescu, Miguel N Rivera, Nicolò Riggi

Therapy-induced APOBEC3A drives evolution of persistent cancer cells

治疗诱导的APOBEC3A驱动持续性癌细胞的进化

Hideko Isozaki ,Ramin Sakhtemani ,Ammal Abbasi ,Naveed Nikpour ,Marcello Stanzione ,Sunwoo Oh ,Adam Langenbucher ,Susanna Monroe ,Wenjia Su ,Heidie Frisco Cabanos ,Faria M Siddiqui ,Nicole Phan ,Pégah Jalili ,Daria Timonina ,Samantha Bilton ,Maria Gomez-Caraballo ,Hannah L Archibald ,Varuna Nangia ,Kristin Dionne ,Amanda Riley ,Matthew Lawlor ,Mandeep Kaur Banwait ,Rosemary G Cobb ,Lee Zou ,Nicholas J Dyson ,Christopher J Ott ,Cyril Benes ,Gad Getz ,Chang S Chan ,Alice T Shaw ,Justin F Gainor ,Jessica J Lin ,Lecia V Sequist ,Zofia Piotrowska ,Beow Y Yeap ,Jeffrey A Engelman ,Jake June-Koo Lee ,Yosef E Maruvka ,Rémi Buisson ,Michael S Lawrence # ,Aaron N Hata #

Acetyl-CoA biosynthesis drives resistance to histone acetyltransferase inhibition

乙酰辅酶A生物合成驱动对组蛋白乙酰转移酶抑制剂的抗性

Timothy R Bishop,Chitra Subramanian,Eric M Bilotta,Leopold Garnar-Wortzel,Anissa R Ramos,Yuxiang Zhang,Joshua N Asiaban,Christopher J Ott,Charles O Rock,Michael A Erb

Collateral lethality between HDAC1 and HDAC2 exploits cancer-specific NuRD complex vulnerabilities

HDAC1 和 HDAC2 之间的附带致死性利用了癌症特异性 NuRD 复合物的脆弱性

Yuxiang Zhang, David Remillard, Ugoma Onubogu, Barbara Karakyriakou, Joshua N Asiaban, Anissa R Ramos, Kirsten Bowland, Timothy R Bishop, Paige A Barta, Stephanie Nance, Adam D Durbin, Christopher J Ott, Michalina Janiszewska, Benjamin F Cravatt, Michael A Erb

A hotspot mutation in transcription factor IKZF3 drives B cell neoplasia via transcriptional dysregulation

转录因子IKZF3中的热点突变通过转录失调驱动B细胞肿瘤的发生

Gregory Lazarian ,Shanye Yin ,Elisa Ten Hacken ,Tomasz Sewastianik ,Mohamed Uduman ,Alba Font-Tello ,Satyen H Gohil ,Shuqiang Li ,Ekaterina Kim ,Heather Joyal ,Leah Billington ,Elizabeth Witten ,Mei Zheng ,Teddy Huang ,Mariano Severgnini ,Valerie Lefebvre ,Laura Z Rassenti ,Catherine Gutierrez ,Katia Georgopoulos ,Christopher J Ott ,Lili Wang ,Thomas J Kipps ,Jan A Burger ,Kenneth J Livak ,Donna S Neuberg ,Fanny Baran-Marszak ,Florence Cymbalista ,Ruben D Carrasco ,Catherine J Wu

Targeting oncoproteins with a positive selection assay for protein degraders

利用蛋白质降解剂的阳性选择检测方法靶向癌蛋白

Vidyasagar Koduri ,Leslie Duplaquet ,Benjamin L Lampson ,Adam C Wang ,Amin H Sabet ,Mette Ishoey ,Joshiawa Paulk ,Mingxing Teng ,Isaac S Harris ,Jennifer E Endress ,Xiaoxi Liu ,Ethan Dasilva ,Joao A Paulo ,Kimberly J Briggs ,John G Doench ,Christopher J Ott ,Tinghu Zhang ,Katherine A Donovan ,Eric S Fischer ,Steven P Gygi ,Nathanael S Gray ,James Bradner ,Jeffrey A Medin ,Sara J Buhrlage ,Matthew G Oser ,William G Kaelin Jr

Selective targeting of MYC mRNA by stabilized antisense oligonucleotides

稳定反义寡核苷酸选择性靶向 MYC mRNA

Taylor Gill, Haichuan Wang, Raj Bandaru, Matthew Lawlor, Chenyue Lu, Linda T Nieman, Junyan Tao, Yixian Zhang, Daniel G Anderson, David T Ting, Xin Chen, James E Bradner, Christopher J Ott

Targeted degradation of the enhancer lysine acetyltransferases CBP and p300

增强子赖氨酸乙酰转移酶 CBP 和 p300 的靶向降解

Raghu Vannam, Jan Sayilgan, Samuel Ojeda, Barbara Karakyriakou, Eileen Hu, Johannes Kreuzer, Robert Morris, Xcanda Ixchel Herrera Lopez, Sumit Rai, Wilhelm Haas, Michael Lawrence, Christopher J Ott

Small-molecule targeting of brachyury transcription factor addiction in chordoma

脊索瘤中短尾转录因子成瘾的小分子靶向

Tanaz Sharifnia, Mathias J Wawer, Ting Chen, Qing-Yuan Huang, Barbara A Weir, Ann Sizemore, Matthew A Lawlor, Amy Goodale, Glenn S Cowley, Francisca Vazquez, Christopher J Ott, Joshua M Francis, Slim Sassi, Patricia Cogswell, Hadley E Sheppard, Tinghu Zhang, Nathanael S Gray, Paul A Clarke, Julian B