日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Intrastriatal injection of alpha-synuclein preformed fibrils to rats results in L-DOPA reversible sensorimotor impairments and alterations in non-motor function.

向大鼠纹状体内注射α-突触核蛋白预成型原纤维会导致左旋多巴可逆的感觉运动障碍和非运动功能改变

Fleming Sheila M, Scott Sophia, Hamad Edward J, Herman Danielle E, Holden John G, Yan Lily, Linning-Duffy Katrina, Kemp Christopher J, Patterson Joseph R, Miller Kathryn M, Kubik Michael, Kuhn Nathan, Stoll Anna C, Duffy Megan F, Steece-Collier Kathy, Cole-Strauss Allyson, Lipton Jack W, Luk Kelvin C, Sortwell Caryl E

Desert diversity: genome sequence of Gordonia rubripertincta cluster DJ phage Mossy and cluster DV phage Erutan

沙漠多样性:Gordonia rubripertincta 簇 DJ 噬菌体 Mossy 和簇 DV 噬菌体 Erutan 的基因组序列

Barnes, October; Workman, Christopher J; Patterson, Noah C; Oesch, Riley; Johnson, Katie L; Goncz, Kaarin; Sharbrough, Joel; DeVeaux, Linda C

Core Protein-Directed Antivirals and Importin β Can Synergistically Disrupt Hepatitis B Virus Capsids

针对核心蛋白的抗病毒药物和输入蛋白β可协同破坏乙型肝炎病毒衣壳

Kim, Christine; Barnes, Lauren F; Schlicksup, Christopher J; Patterson, Angela J; Bothner, Brian; Jarrold, Martin F; Wang, Che-Yen Joseph; Zlotnick, Adam

The HCK/BTK inhibitor KIN-8194 is active in MYD88-driven lymphomas and overcomes mutated BTKCys481 ibrutinib resistance

HCK/BTK 抑制剂 KIN-8194 对 MYD88 驱动的淋巴瘤有效,并可克服突变的 BTKCys481 依鲁替尼耐药性

Guang Yang, Jinhua Wang, Li Tan, Manit Munshi, Xia Liu, Amanda Kofides, Jiaji G Chen, Nicholas Tsakmaklis, Maria G Demos, Maria Luisa Guerrera, Lian Xu, Zachary R Hunter, Jinwei Che, Christopher J Patterson, Kirsten Meid, Jorge J Castillo, Nikhil C Munshi, Kenneth C Anderson, Michael Cameron, Sara J

Expression of the prosurvival kinase HCK requires PAX5 and mutated MYD88 signaling in MYD88-driven B-cell lymphomas

在 MYD88 驱动的 B 细胞淋巴瘤中,促生存激酶 HCK 的表达需要 PAX5 和突变的 MYD88 信号传导

Xia Liu, Jiaji G Chen, Manit Munshi, Zachary R Hunter, Lian Xu, Amanda Kofides, Nickolas Tsakmaklis, Maria G Demos, Maria Luisa Guerrera, Gloria G Chan, Cristina Jimenez, Christopher J Patterson, Kirsten Meid, Andrew Keezer, Jorge J Castillo, Steven P Treon, Guang Yang

Simultaneous Transcatheter Double Valve Treatment of Mediastinal Radiation-Induced Severe Calcific Aortic and Mitral Stenosis

同时经导管双瓣膜治疗纵隔放射性严重钙化性主动脉瓣和二尖瓣狭窄

Allen, Christopher J; Patterson, Tiffany; Prendergast, Bernard; Roberts-Thompson, Ross L; Rajani, Ronak; Redwood, Simon R

BTKCys481Ser drives ibrutinib resistance via ERK1/2 and protects BTKwild-type MYD88-mutated cells by a paracrine mechanism

BTKCys481Ser 通过 ERK1/2 驱动伊布替尼耐药性,并通过旁分泌机制保护 BTKwild 型 MYD88 突变细胞

Jiaji G Chen, Xia Liu, Manit Munshi, Lian Xu, Nicholas Tsakmaklis, Maria G Demos, Amanda Kofides, Maria Luisa Guerrera, Gloria G Chan, Christopher J Patterson, Kirsten Meid, Joshua Gustine, Toni Dubeau, Patricia Severns, Jorge J Castillo, Zachary R Hunter, Jinhua Wang, Sara J Buhrlage, Nathanael S G

HCK is a survival determinant transactivated by mutated MYD88, and a direct target of ibrutinib

HCK 是一种由突变的 MYD88 反式激活的生存决定因子,也是依鲁替尼的直接靶点

Guang Yang, Sara J Buhrlage, Li Tan, Xia Liu, Jie Chen, Lian Xu, Nicholas Tsakmaklis, Jiaji G Chen, Christopher J Patterson, Jennifer R Brown, Jorge J Castillo, Wei Zhang, Xiaofeng Zhang, Shuai Liu, Philip Cohen, Zachary R Hunter, Nathanael Gray, Steven P Treon