日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Interplay between ATRX and IDH1 mutations governs innate immune responses in diffuse gliomas

ATRX 和 IDH1 突变之间的相互作用调控弥漫性胶质瘤的先天免疫反应

Seethalakshmi Hariharan # ,Benjamin T Whitfield # ,Christopher J Pirozzi ,Matthew S Waitkus ,Michael C Brown ,Michelle L Bowie ,David M Irvin ,Kristen Roso ,Rebecca Fuller ,Janell Hostettler ,Sharvari Dharmaiah ,Emiley A Gibson ,Aaron Briley ,Avani Mangoli ,Casey Fraley ,Mariah Shobande ,Kevin Stevenson ,Gao Zhang ,Prit Benny Malgulwar ,Hannah Roberts ,Martin Roskoski ,Ivan Spasojevic ,Stephen T Keir ,Yiping He ,Maria G Castro ,Jason T Huse ,David M Ashley

Targeting Catechol-O-Methyltransferase Induces Mitochondrial Dysfunction and Enhances the Efficacy of Radiotherapy in Glioma

靶向儿茶酚-O-甲基转移酶可诱导线粒体功能障碍并增强放射疗法对胶质瘤的疗效

Meng Jiao ,Christopher J Pirozzi ,Chen Yu ,Xuhui Bao ,Mengjie Hu ,Dong Pan ,Sejiro Littleton ,Nathan Reynolds ,Daniel R Saban ,Fang Li ,Chuan-Yuan Li

The CCL5/CCR5/SHP2 axis sustains Stat1 phosphorylation and activates NF-κB signaling promoting M1 macrophage polarization and exacerbating chronic prostatic inflammation

CCL5/CCR5/SHP2 轴维持 Stat1 磷酸化并激活 NF-κB 信号,促进 M1 巨噬细胞极化并加剧慢性前列腺炎症

Chen Jin #, Fei Zhang #, Hailang Luo, Boyang Li, Xue Jiang, Christopher J Pirozzi, Chaozhao Liang, Meng Zhang0

Repurposing Clemastine to Target Glioblastoma Cell Stemness

重新利用氯马斯汀来靶向胶质母细胞瘤细胞干细胞

Michael A Sun, Rui Yang, Heng Liu, Wenzhe Wang, Xiao Song, Bo Hu, Nathan Reynolds, Kristen Roso, Lee H Chen, Paula K Greer, Stephen T Keir, Roger E McLendon, Shi-Yuan Cheng, Darell D Bigner, David M Ashley, Christopher J Pirozzi, Yiping He

Purine Synthesis Inhibitor L-Alanosine Impairs Mitochondrial Function and Stemness of Brain Tumor Initiating Cells

嘌呤合成抑制剂L-丙氨酸会损害脑肿瘤起始细胞的线粒体功能和干性

Simranjit X Singh ,Rui Yang ,Kristen Roso ,Landon J Hansen ,Changzheng Du ,Lee H Chen ,Paula K Greer ,Christopher J Pirozzi ,Yiping He

MTAP loss correlates with an immunosuppressive profile in GBM and its substrate MTA stimulates alternative macrophage polarization

MTAP 损失与 GBM 中的免疫抑制特征相关,其底物 MTA 刺激替代巨噬细胞极化

Landon J Hansen, Rui Yang, Kristen Roso, Wenzhe Wang, Lee Chen, Qing Yang, Christopher J Pirozzi, Yiping He

TP53 wild-type/PPM1D mutant diffuse intrinsic pontine gliomas are sensitive to a MDM2 antagonist

TP53 野生型/PPM1D 突变型弥漫性内在性脑桥神经胶质瘤对 MDM2 拮抗剂敏感

Cheng Xu #, Heng Liu #, Christopher J Pirozzi, Lee H Chen, Paula K Greer, Bill H Diplas, Liwei Zhang, Matthew S Waitkus, Yiping He, Hai Yan

Epigenetic Regulation of Fanconi Anemia Genes Implicates PRMT5 Blockage as a Strategy for Tumor Chemosensitization

范康尼贫血基因的表观遗传调控表明 PRMT5 阻断是肿瘤化学增敏的一种策略

Changzheng Du, Steven W Li, Simranjit X Singh, Kristen Roso, Michael A Sun, Christopher J Pirozzi, Rui Yang, Jian-Liang Li, Yiping He

MTAP Loss Promotes Stemness in Glioblastoma and Confers Unique Susceptibility to Purine Starvation

MTAP 缺失促进胶质母细胞瘤的干细胞形成,并赋予其对嘌呤饥饿的独特敏感性

Landon J Hansen #, Ran Sun #, Rui Yang, Simranjit X Singh, Lee H Chen, Christopher J Pirozzi, Casey J Moure, Carlee Hemphill, Austin B Carpenter, Patrick Healy, Ryan C Ruger, Chin-Pu J Chen, Paula K Greer, Fangping Zhao, Ivan Spasojevic, Carole Grenier, Zhiqing Huang, Susan K Murphy, Roger E McLendo

CRISPR Editing of Mutant IDH1 R132H Induces a CpG Methylation-Low State in Patient-Derived Glioma Models of G-CIMP

突变型 IDH1 R132H 的 CRISPR 编辑在 G-CIMP 患者源性胶质瘤模型中诱导 CpG 甲基化低状态

Casey J Moure, Bill H Diplas, Lee H Chen, Rui Yang, Christopher J Pirozzi, Zhaohui Wang, Ivan Spasojevic, Matthew S Waitkus, Yiping He, Hai Yan