日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Interleukin-2-secreting T helper cells promote extra-follicular B cell maturation via intrinsic regulation of a B cell mTOR-AKT-Blimp-1 axis

分泌白细胞介素-2的辅助性T细胞通过对B细胞mTOR-AKT-Blimp-1轴的内在调控促进滤泡外B细胞成熟。

Caterina E Faliti ,Maria Mesina ,Jinyong Choi ,Simon Bélanger ,Monique A Marshall ,Christopher M Tipton ,Sakeenah Hicks ,Prashanti Chappa ,Maria A Cardenas ,Mohamed Abdel-Hakeem ,Theresa C Thinnes ,Christopher Cottrell ,Christopher D Scharer ,William R Schief ,David Nemazee ,Matthew C Woodruff ,John M Lindner ,Ignacio Sanz ,Shane Crotty

Distinct transcriptomes and autocrine cytokines underpin maturation and survival of antibody-secreting cells in systemic lupus erythematosus

系统性红斑狼疮中抗体分泌细胞的成熟和存活依赖于独特的转录组和自分泌细胞因子。

Weirong Chen # ,So-Hee Hong # ,Scott A Jenks ,Fabliha A Anam ,Christopher M Tipton ,Matthew C Woodruff ,Jennifer R Hom ,Kevin S Cashman ,Caterina Elisa Faliti ,Xiaoqian Wang ,Shuya Kyu ,Chungwen Wei ,Christopher D Scharer ,Tian Mi ,Sakeenah Hicks ,Louise Hartson ,Doan C Nguyen ,Arezou Khosroshahi ,Saeyun Lee ,Youliang Wang ,Regina Bugrovsky ,Yusho Ishii ,F Eun-Hyung Lee ,Ignacio Sanz

A transcriptionally distinct subset of influenza-specific effector memory B cells predicts long-lived antibody responses to vaccination in humans

流感特异性效应记忆B细胞的一个转录特征独特的亚群可预测人类接种疫苗后产生的长效抗体反应。

Anoma Nellore,Esther Zumaquero,Christopher D Scharer,Christopher F Fucile,Christopher M Tipton,R Glenn King,Tian Mi,Betty Mousseau,John E Bradley,Fen Zhou,Stuti Mutneja,Paul A Goepfert,Jeremy M Boss,Troy D Randall,Ignacio Sanz,Alexander F Rosenberg,Frances E Lund

Single-cell analysis of human nasal mucosal IgE antibody secreting cells reveals a newly minted phenotype

人类鼻粘膜 IgE 抗体分泌细胞的单细胞分析揭示了一种新的表型

Richard P Ramonell, Margaret Brown, Matthew C Woodruff, Joshua M Levy, Sarah K Wise, John DelGaudio, Meixue Duan, Celia L Saney, Shuya Kyu, Kevin S Cashman, Jennifer R Hom, Christopher F Fucile, Alexander F Rosenberg, Christopher M Tipton, Ignacio Sanz, Gregory C Gibson, F Eun-Hyung Lee

Understanding heterogeneity of human bone marrow plasma cell maturation and survival pathways by single-cell analyses

通过单细胞分析了解人类骨髓浆细胞成熟和存活途径的异质性

Meixue Duan ,Doan C Nguyen ,Chester J Joyner ,Celia L Saney ,Christopher M Tipton ,Joel Andrews ,Sagar Lonial ,Caroline Kim ,Ian Hentenaar ,Astrid Kosters ,Eliver Ghosn ,Annette Jackson ,Stuart Knechtle ,Stalinraja Maruthamuthu ,Sindhu Chandran ,Tom Martin ,Raja Rajalingam ,Flavio Vincenti ,Cynthia Breeden ,Ignacio Sanz ,Greg Gibson ,F Eun-Hyung Lee

Dysregulated naive B cells and de novo autoreactivity in severe COVID-19

重症新冠肺炎中幼稚B细胞失调和新生自身反应性

Matthew C Woodruff # ,Richard P Ramonell # ,Natalie S Haddad ,Fabliha A Anam ,Mark E Rudolph ,Tiffany A Walker ,Alexander D Truong ,Adviteeya N Dixit ,Jenny E Han ,Monica Cabrera-Mora ,Martin C Runnstrom ,Regina Bugrovsky ,Jennifer Hom ,Erin C Connolly ,Igor Albizua ,Vidhi Javia ,Kevin S Cashman ,Doan C Nguyen ,Shuya Kyu ,Ankur Singh Saini ,Michael Piazza ,Christopher M Tipton ,Arezou Khosroshahi ,Greg Gibson ,Greg S Martin ,Cheryl L Maier ,Annette Esper ,Scott A Jenks ,F Eun-Hyung Lee ,Ignacio Sanz

Partial RAG deficiency in humans induces dysregulated peripheral lymphocyte development and humoral tolerance defect with accumulation of T-bet+ B cells

人类 RAG 部分缺乏可导致外周淋巴细胞发育失调和体液耐受缺陷,并伴有 T-bet+ B 细胞积聚

Krisztian Csomos, Boglarka Ujhazi, Peter Blazso, Jose L Herrera, Christopher M Tipton, Tomoki Kawai, Sumai Gordon, Maryssa Ellison, Kevin Wu, Matthew Stowell, Lauren Haynes, Rachel Cruz, Bence Zakota, Johnny Nguyen, Michelle Altrich, Christoph B Geier, Svetlana Sharapova, Joseph F Dasso, Jennifer W

Atypical B cells up-regulate costimulatory molecules during malaria and secrete antibodies with T follicular helper cell support

非典型 B 细胞在疟疾期间上调共刺激分子并在 T 滤泡辅助细胞支持下分泌抗体

Christine S Hopp, Jeff Skinner, Sarah L Anzick, Christopher M Tipton, Mary E Peterson, Shanping Li, Safiatou Doumbo, Kassoum Kayentao, Aissata Ongoiba, Craig Martens, Boubacar Traore, Peter D Crompton

Plasmodium falciparum-specific IgM B cells dominate in children, expand with malaria, and produce functional IgM

恶性疟原虫特异性 IgM B 细胞在儿童中占主导地位,随着疟疾的发生而扩增,并产生功能性 IgM

Christine S Hopp, Padmapriya Sekar, Ababacar Diouf, Kazutoyo Miura, Kristin Boswell, Jeff Skinner, Christopher M Tipton, Mary E Peterson, Michael J Chambers, Sarah Andrews, Jinghua Lu, Joshua Tan, Shanping Li, Safiatou Doumbo, Kassoum Kayentao, Aissata Ongoiba, Boubacar Traore, Silvia Portugal, Pete

Extrafollicular B cell responses correlate with neutralizing antibodies and morbidity in COVID-19

滤泡外B细胞反应与中和抗体和COVID-19发病率相关

Matthew C Woodruff # ,Richard P Ramonell # ,Doan C Nguyen ,Kevin S Cashman ,Ankur Singh Saini ,Natalie S Haddad ,Ariel M Ley ,Shuya Kyu ,J Christina Howell ,Tugba Ozturk ,Saeyun Lee ,Naveenchandra Suryadevara ,James Brett Case ,Regina Bugrovsky ,Weirong Chen ,Jacob Estrada ,Andrea Morrison-Porter ,Andrew Derrico ,Fabliha A Anam ,Monika Sharma ,Henry M Wu ,Sang N Le ,Scott A Jenks ,Christopher M Tipton ,Bashar Staitieh ,John L Daiss ,Eliver Ghosn ,Michael S Diamond ,Robert H Carnahan ,James E Crowe Jr ,William T Hu ,F Eun-Hyung Lee ,Ignacio Sanz