日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Novel MECP2 gene therapy is effective in a multicenter study using two mouse models of Rett syndrome and is safe in non-human primates

新型 MECP2 基因疗法在一项使用两种雷特综合征小鼠模型的多中心研究中表现出疗效,且在非人类灵长类动物中安全

Samantha Powers, Shibi Likhite, Kamal K Gadalla, Carlos J Miranda, Amy J Huffenberger, Cassandra Dennys, Kevin D Foust, Pablo Morales, Christopher R Pierson, Federica Rinaldi, Stephanie Perry, Brad Bolon, Nicolas Wein, Stuart Cobb, Brian K Kaspar, Kathrin C Meyer

Astroblastomas exhibit radial glia stem cell lineages and differential expression of imprinted and X-inactivation escape genes

星形母细胞瘤表现出放射状胶质干细胞谱系以及印记和 X 失活逃逸基因的差异表达

Norman L Lehman, Nathalie Spassky, Müge Sak, Amy Webb, Cory T Zumbar, Aisulu Usubalieva, Khaled J Alkhateeb, Joseph P McElroy, Kirsteen H Maclean, Paolo Fadda, Tom Liu, Vineela Gangalapudi, Jamie Carver, Zied Abdullaev, Cynthia Timmers, John R Parker, Christopher R Pierson, Bret C Mobley, Murat Gokd

Molecular and spatial heterogeneity of microglia in Rasmussen encephalitis

拉斯穆森脑炎中小胶质细胞的分子和空间异质性

Jesse J Westfall, Wesley N Schwind, Sahibjot Sran, Jason B Navarro, Jeffrey Leonard, Jonathan A Pindrik, Christopher R Pierson, Daniel R Boué, Daniel C Koboldt, Adam P Ostendorf, Richard K Wilson, Elaine R Mardis, Katherine E Miller, Tracy A Bedrosian2

PTEN somatic mutations contribute to spectrum of cerebral overgrowth

PTEN 体细胞突变导致一系列脑过度生长

Daniel C Koboldt, Katherine E Miller, Anthony R Miller, Jocelyn M Bush, Sean McGrath, Kristen Leraas, Erin Crist, Summer Fair, Wesley Schwind, Saranga Wijeratne, James Fitch, Jeffrey Leonard, Ammar Shaikhouni, Mark E Hester, Vincent Magrini, Mai-Lan Ho, Christopher R Pierson, Richard K Wilson, Adam

LLL12B, a small molecule STAT3 inhibitor, induces growth arrest, apoptosis, and enhances cisplatin-mediated cytotoxicity in medulloblastoma cells

LLL12B 是一种小分子 STAT3 抑制剂,可诱导髓母细胞瘤细胞生长停滞、细胞凋亡,并增强顺铂介导的细胞毒性

Xiang Chen #, Li Pan #, Jia Wei, Ruijie Zhang, Xiaozhi Yang, Jinhua Song, Ren-Yuan Bai, Shengling Fu, Christopher R Pierson, Jonathan L Finlay, Chenglong Li, Jiayuh Lin

ΔNp73/ETS2 complex drives glioblastoma pathogenesis- targeting downstream mediators by rebastinib prolongs survival in preclinical models of glioblastoma

ΔNp73/ETS2 复合物驱动胶质母细胞瘤发病机制 - 通过瑞巴替尼靶向下游介质延长胶质母细胞瘤临床前模型的生存期

Maren Cam, Manish Charan, Alessandra M Welker, Piyush Dravid, Adam W Studebaker, Jeffrey R Leonard, Christopher R Pierson, Ichiro Nakano, Christine E Beattie, Eugene I Hwang, Madhuri Kambhampati, Javad Nazarian, Jonathan L Finlay, Hakan Cam

Blocking interleukin-6 signaling inhibits cell viability/proliferation, glycolysis, and colony forming activity of human medulloblastoma cells

阻断白细胞介素 6 信号传导可抑制人类髓母细胞瘤细胞的细胞活力/增殖、糖酵解和集落形成活性

Xiang Chen, Jia Wei, Chenglong Li, Christopher R Pierson, Jonathan L Finlay, Jiayuh Lin

Hepcidin, an Iron Regulatory Hormone of Innate Immunity, is Differentially Expressed in Premature Fetuses with Early-Onset Neonatal Sepsis

铁调素是一种先天免疫的铁调节激素,在早发性新生儿脓毒症的早产胎儿中存在差异表达

Sammy M Tabbah, Catalin S Buhimschi, Katherine Rodewald-Millen, Christopher R Pierson, Vineet Bhandari, Philip Samuels, Irina A Buhimschi

Immune profiling of NF1-associated tumors reveals histologic subtype distinctions and heterogeneity: implications for immunotherapy

NF1 相关肿瘤的免疫分析揭示了组织学亚型的区别和异质性:对免疫治疗的意义

Kellie B Haworth, Michael A Arnold, Christopher R Pierson, Kwangmin Choi, Nicholas D Yeager, Nancy Ratner, Ryan D Roberts, Jonathan L Finlay, Timothy P Cripe

SPEG interacts with myotubularin, and its deficiency causes centronuclear myopathy with dilated cardiomyopathy

SPEG 与肌管蛋白相互作用,其缺乏会导致扩张型心肌病的中心核肌病

Pankaj B Agrawal, Christopher R Pierson, Mugdha Joshi, Xiaoli Liu, Gianina Ravenscroft, Behzad Moghadaszadeh, Tiffany Talabere, Marissa Viola, Lindsay C Swanson, Göknur Haliloğlu, Beril Talim, Kyle S Yau, Richard J N Allcock, Nigel G Laing, Mark A Perrella, Alan H Beggs