日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A critical role of FAK signaling in Rac1-driven melanoma cell resistance to MAPK pathway inhibition

FAK信号通路在Rac1驱动的黑色素瘤细胞对MAPK通路抑制的耐药性中起关键作用

Jesse D Riordan,Teagan A Nathanson,Afshin Varzavand,Adeline A Hawkins,Rebekah M Peplinski,Elizabeth C Hannan,Faith A Bibeau,Nathaniel J Freesmeier,Madison C Jilek,Silvia Coma,Jonathan A Pachter,Adam J Dupuy,Christopher S Stipp

The highly metastatic 4T1 breast carcinoma model possesses features of a hybrid epithelial/mesenchymal phenotype

高转移性4T1乳腺癌模型具有混合上皮/间质表型的特征

Mary E Herndon ,Mitchell Ayers ,Katherine N Gibson-Corley ,Michael K Wendt ,Lori L Wallrath ,Michael D Henry ,Christopher S Stipp

Single-cell genomics analysis reveals complex genetic interactions in an in vivo model of acquired BRAF inhibitor resistance

单细胞基因组学分析揭示了获得性 BRAF 抑制剂耐药体内模型中复杂的遗传相互作用

Jacob L Schillo, Charlotte R Feddersen, Rebekah M Peplinski, Lexy S Powell, Afshin Varzavand, Christopher S Stipp, Jesse D Riordan, Adam J Dupuy

EWS-FLI1 and Activator Protein-1 (AP-1) Reciprocally Regulate Extracellular-Matrix Proteins in Ewing sarcoma Cells

EWS-FLI1 和激活蛋白-1 (AP-1) 相互调节尤文氏肉瘤细胞中的细胞外基质蛋白

Emma E Croushore, Christopher S Stipp, David J Gordon

SRC-RAC1 signaling drives drug resistance to BRAF inhibition in de-differentiated cutaneous melanomas

SRC-RAC1 信号驱动去分化皮肤黑色素瘤对 BRAF 抑制产生耐药性

Eliot Y Zhu, Jesse D Riordan, Marion Vanneste, Michael D Henry, Christopher S Stipp, Adam J Dupuy

PRC2 loss drives MPNST metastasis and matrix remodeling

PRC2 缺失驱动 MPNST 转移和基质重塑

Qierra R Brockman ,Amanda Scherer ,Gavin R McGivney ,Wade R Gutierrez ,Andrew P Voigt ,Alexandra L Isaacson ,Emily A Laverty ,Grace Roughton ,Vickie Knepper-Adrian ,Benjamin Darbro ,Munir R Tanas ,Christopher S Stipp ,Rebecca D Dodd

Cancer Cells Resist Mechanical Destruction in Circulation via RhoA/Actomyosin-Dependent Mechano-Adaptation

癌细胞通过RhoA/肌动蛋白依赖的机械适应机制抵抗循环中的机械破坏

Devon L Moose ,Benjamin L Krog ,Tae-Hyung Kim ,Lei Zhao ,Sophia Williams-Perez ,Gretchen Burke ,Lillian Rhodes ,Marion Vanneste ,Patrick Breheny ,Mohammed Milhem ,Christopher S Stipp ,Amy C Rowat ,Michael D Henry

Functional Genomic Screening Independently Identifies CUL3 as a Mediator of Vemurafenib Resistance via Src-Rac1 Signaling Axis

功能基因组筛选独立鉴定出CUL3通过Src-Rac1信号轴介导维莫非尼耐药性

Marion Vanneste ,Charlotte R Feddersen ,Afshin Varzavand ,Elliot Y Zhu ,Tyler Foley ,Lei Zhao ,Kathleen H Holt ,Mohammed Milhem ,Robert Piper ,Christopher S Stipp ,Adam J Dupuy ,Michael D Henry

Src-Dependent DBL Family Members Drive Resistance to Vemurafenib in Human Melanoma

Src 依赖性 DBL 家族成员导致人类黑色素瘤对维莫非尼产生耐药性

Charlotte R Feddersen, Jacob L Schillo, Afshin Varzavand, Hayley R Vaughn, Lexy S Wadsworth, Andrew P Voigt, Eliot Y Zhu, Brooke M Jennings, Sarah A Mullen, Jeremy Bobera, Jesse D Riordan, Christopher S Stipp, Adam J Dupuy

Chronic liver injury alters driver mutation profiles in hepatocellular carcinoma in mice

慢性肝损伤改变小鼠肝细胞癌的驱动突变谱

Jesse D Riordan, Charlotte R Feddersen, Barbara R Tschida, Pauline J Beckmann, Vincent W Keng, Michael A Linden, Khalid Amin, Christopher S Stipp, David A Largaespada, Adam J Dupuy