日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Fragment-Based Design of a Potent MAT2a Inhibitor and in Vivo Evaluation in an MTAP Null Xenograft Model

基于片段的有效 MAT2a 抑制剂设计以及在 MTAP 无效异种移植模型中的体内评估

Claudia De Fusco, Marianne Schimpl, Ulf Börjesson, Tony Cheung, Iain Collie, Laura Evans, Priyanka Narasimhan, Christopher Stubbs, Mercedes Vazquez-Chantada, David J Wagner, Michael Grondine, Matthew G Sanders, Sharon Tentarelli, Elizabeth Underwood, Argyrides Argyrou, James M Smith, James T Lynch, 

Structural insights and activating mutations in diverse pathologies define mechanisms of deregulation for phospholipase C gamma enzymes

结构洞察和不同病理中的激活突变定义了磷脂酶 C γ 酶失调的机制

Yang Liu, Tom D Bunney, Sakshi Khosa, Kévin Macé, Katharina Beckenbauer, Trevor Askwith, Sarah Maslen, Christopher Stubbs, Taiana M de Oliveira, Kasim Sader, Mark Skehel, Anne-Claude Gavin, Christopher Phillips, Matilda Katan

KRAS-specific inhibition using a DARPin binding to a site in the allosteric lobe

使用 DARPin 与变构叶中的位点结合来进行 KRAS 特异性抑制

Nicolas Bery, Sandrine Legg, Judit Debreczeni, Jason Breed, Kevin Embrey, Christopher Stubbs, Paulina Kolasinska-Zwierz, Nathalie Barrett, Rose Marwood, Jo Watson, Jon Tart, Ross Overman, Ami Miller, Christopher Phillips, Ralph Minter, Terence H Rabbitts

Mechanical Loading Promotes the Expansion of Primitive Osteoprogenitors and Organizes Matrix and Vascular Morphology in Long Bone Defects

机械负荷促进长骨缺损中原始骨祖细胞的扩增并组织基质和血管形态

Chao Liu, Pamela Cabahug-Zuckerman, Christopher Stubbs, Martin Pendola, Cinyee Cai, Kenneth A Mann, Alesha B Castillo