日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

EML4-ALK Variant-Specific Genetic Interactions Shape Lung Tumorigenesis

EML4-ALK 变异特异性基因相互作用影响肺肿瘤发生

Alberto Diaz-Jimenez #,Emily G Shuldiner #,Kalman Somogyi,Karen Y Shih,Óscar González-Velasco,Mulham Najajreh,Stewart Kim,Filiz Akkas,Christopher W Murray,Laura Andrejka,Min K Tsai,Benedikt Brors,Ilse Hofmann,Smruthy Sivakumar,Saumya D Sisoudiya,Ethan S Sokol,Hongchen Cai,Dmitri A Petrov,Monte M Winslow,Rocio Sotillo

Multiplexed screens identify RAS paralogues HRAS and NRAS as suppressors of KRAS-driven lung cancer growth

多重筛选鉴定出 RAS 同源基因 HRAS 和 NRAS 是 KRAS 驱动的肺癌生长的抑制因子

Rui Tang # ,Emily G Shuldiner # ,Marcus Kelly ,Christopher W Murray ,Jess D Hebert ,Laura Andrejka ,Min K Tsai ,Nicholas W Hughes ,Mitchell I Parker ,Hongchen Cai ,Yao-Cheng Li ,Geoffrey M Wahl ,Roland L Dunbrack ,Peter K Jackson ,Dmitri A Petrov ,Monte M Winslow

Multiplexed screens identify RAS paralogues HRAS and NRAS as suppressors of KRAS-driven lung cancer growth

多重筛选鉴定出 RAS 同源基因 HRAS 和 NRAS 是 KRAS 驱动的肺癌生长的抑制因子

Rui Tang #,Emily G Shuldiner #,Marcus Kelly,Christopher W Murray,Jess D Hebert,Laura Andrejka,Min K Tsai,Nicholas W Hughes,Mitchell I Parker,Hongchen Cai,Yao-Cheng Li,Geoffrey M Wahl,Roland L Dunbrack,Peter K Jackson,Dmitri A Petrov ,Monte M Winslow

Phagocytosis increases an oxidative metabolic and immune suppressive signature in tumor macrophages

吞噬作用会增强肿瘤巨噬细胞的氧化代谢和免疫抑制特征。

Michael A Gonzalez # ,Daniel R Lu # ,Maryam Yousefi ,Ashley Kroll ,Chen Hao Lo ,Carlos G Briseño ,J E Vivienne Watson ,Sergey Novitskiy ,Vanessa Arias ,Hong Zhou ,Andres Plata Stapper ,Min K Tsai ,Emily L Ashkin ,Christopher W Murray ,Chi-Ming Li ,Monte M Winslow ,Kristin V Tarbell

A multiplexed in vivo approach to identify driver genes in small cell lung cancer

一种用于鉴定小细胞肺癌驱动基因的多重体内方法

Myung Chang Lee ,Hongchen Cai ,Christopher W Murray ,Chuan Li ,Yan Ting Shue ,Laura Andrejka ,Andy L He ,Alessandra M E Holzem ,Alexandros P Drainas ,Julie H Ko ,Garry L Coles ,Christina Kong ,Shirley Zhu ,ChunFang Zhu ,Jason Wang ,Matt van de Rijn ,Dmitri A Petrov ,Monte M Winslow ,Julien Sage

A multiplexed in vivo approach to identify driver genes in small cell lung cancer

一种用于鉴定小细胞肺癌驱动基因的多重体内方法

Myung Chang Lee,Hongchen Cai,Christopher W Murray,Chuan Li,Yan Ting Shue,Laura Andrejka,Andy L He,Alessandra M E Holzem,Alexandros P Drainas,Julie H Ko,Garry L Coles,Christina Kong,Shirley Zhu,ChunFang Zhu,Jason Wang,Matt van de Rijn,Dmitri A Petrov,Monte M Winslow,Julien Sage

LKB1 drives stasis and C/EBP-mediated reprogramming to an alveolar type II fate in lung cancer

LKB1驱动肺癌细胞停滞和C/EBP介导的重编程,使其向II型肺泡细胞命运转变。

Christopher W Murray ,Jennifer J Brady ,Mingqi Han ,Hongchen Cai ,Min K Tsai ,Sarah E Pierce ,Ran Cheng ,Janos Demeter ,David M Feldser ,Peter K Jackson ,David B Shackelford ,Monte M Winslow

Combinatorial Inactivation of Tumor Suppressors Efficiently Initiates Lung Adenocarcinoma with Therapeutic Vulnerabilities

肿瘤抑制基因的组合失活可有效诱发具有治疗弱点的肺腺癌

Maryam Yousefi # ,Gábor Boross # ,Carly Weiss ,Christopher W Murray ,Jess D Hebert ,Hongchen Cai ,Emily L Ashkin ,Saswati Karmakar ,Laura Andrejka ,Leo Chen ,Minwei Wang ,Min K Tsai ,Wen-Yang Lin ,Chuan Li ,Pegah Yakhchalian ,Caterina I Colón ,Su-Kit Chew ,Pauline Chu ,Charles Swanton ,Christian A Kunder ,Dmitri A Petrov ,Monte M Winslow

A Functional Taxonomy of Tumor Suppression in Oncogenic KRAS-Driven Lung Cancer

致癌 KRAS 驱动的肺癌中肿瘤抑制的功能分类

Hongchen Cai #, Su Kit Chew #, Chuan Li #, Min K Tsai, Laura Andrejka, Christopher W Murray, Nicholas W Hughes, Emily G Shuldiner, Emily L Ashkin, Rui Tang, King L Hung, Leo C Chen, Shi Ya C Lee, Maryam Yousefi, Wen-Yang Lin, Christian A Kunder, Le Cong, Christopher D McFarland, Dmitri A Petrov, Cha

A versatile system to record cell-cell interactions

一种用于记录细胞间相互作用的多功能系统

Rui Tang ,Christopher W Murray ,Ian L Linde ,Nicholas J Kramer ,Zhonglin Lyu ,Min K Tsai ,Leo C Chen ,Hongchen Cai ,Aaron D Gitler ,Edgar Engleman ,Wonjae Lee ,Monte M Winslow