Design and Synthesis of Novel Deuterated Ligands Functionally Selective for the γ-Aminobutyric Acid Type A Receptor (GABAAR) α6 Subtype with Improved Metabolic Stability and Enhanced Bioavailability
设计并合成新型氘代配体，该配体对γ-氨基丁酸A型受体（GABAAR）α6亚型具有功能选择性，并具有更高的代谢稳定性和生物利用度。
期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.7b01664
Daniel E Knutson ,Revathi Kodali ,Branka Divović ,Marco Treven ,Michael R Stephen ,Nicolas M Zahn ,Vladimir Dobričić ,Alec T Huber ,Matheus A Meirelles ,Ranjit S Verma ,Laurin Wimmer ,Christopher Witzigmann ,Leggy A Arnold ,Lih-Chu Chiou ,Margot Ernst ,Marko D Mihovilovic ,Miroslav M Savić ,Werner Sieghart ,James M Cook
