日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

APOE deficiency inhibits amyloid-facilitated (A) tau pathology (T) and neurodegeneration (N), halting progressive ATN pathology in a preclinical model

APOE 缺陷抑制淀粉样蛋白促进的 tau 蛋白病理 (T) 和神经退行性变 (N),从而在临床前模型中阻止进行性 ATN 病理的发生。

Sarah Vanherle # ,Art Janssen # ,Manuel Gutiérrez de Ravé # ,Bieke Janssen ,Chritica Lodder ,Pablo Botella Lucena ,Sofie Kessels ,Jana Hardy ,Eline Vandeput ,Yanyan Wang ,Ilie-Cosmin Stancu ,Andrei Segal ,Markus Kleinewietfeld ,Thomas Voets ,Bert Brône ,Suresh Poovathingal ,Yeranddy A Alpizar ,Ilse Dewachter

Blood-based Aβ42 increases in the earliest pre-pathological stage before decreasing with progressive amyloid pathology in preclinical models and human subjects: opening new avenues for prevention

在临床前模型和人类受试者中,血液中的 Aβ42 在最早的病理前阶段增加,然后随着淀粉样蛋白病理的进行而减少:为预防开辟了新途径

Pablo Botella Lucena #, Sarah Vanherle #, Chritica Lodder #, Manuel Gutiérrez de Ravé, Ilie-Cosmin Stancu, Ivo Lambrichts, Riet Vangheluwe, Rose Bruffaerts, Ilse Dewachter

The NLRP3 inflammasome modulates tau pathology and neurodegeneration in a tauopathy model

NLRP3 炎症小体在 tau 病变模型中调节 tau 病理和神经退行性

Ilie Cosmin Stancu, Chritica Lodder, Pablo Botella Lucena, Sarah Vanherle, Manuel Gutiérrez de Ravé, Dick Terwel, Astrid Bottelbergs, Ilse Dewachter

CSF1R inhibition rescues tau pathology and neurodegeneration in an A/T/N model with combined AD pathologies, while preserving plaque associated microglia

CSF1R 抑制可挽救患有 AD 病理的 A/T/N 模型中的 tau 病理和神经退行性病变,同时保留斑块相关的小胶质细胞

Chritica Lodder #, Isabelle Scheyltjens #, Ilie Cosmin Stancu #, Pablo Botella Lucena, Manuel Gutiérrez de Ravé, Sarah Vanherle, Tim Vanmierlo, Niels Cremers, Hannah Vanrusselt, Bert Brône, Bernard Hanseeuw, Jean-Noël Octave, Astrid Bottelbergs, Kiavash Movahedi #, Ilse Dewachter #2

Aggregated Tau activates NLRP3-ASC inflammasome exacerbating exogenously seeded and non-exogenously seeded Tau pathology in vivo

聚集的 Tau 可激活 NLRP3-ASC 炎症小体,加剧体内外源性和非外源性 Tau 病理

Ilie-Cosmin Stancu, Niels Cremers, Hannah Vanrusselt, Julien Couturier, Alexandre Vanoosthuyse, Sofie Kessels, Chritica Lodder, Bert Brône, François Huaux, Jean-Noël Octave, Dick Terwel, Ilse Dewachter