日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Generation and characterization of iPSC-derived microglia for in vitro modeling of stimuli-specific neuroimmune responses.

利用 iPSC 衍生的小胶质细胞进行体外模型构建,以模拟刺激特异性神经免疫反应。

Haskell Angela K, Kulas Joshua A, Carter William E, Javens-Wolfe June, Hinkel Raven Dance, Moussaif Mustapha, Smiley Jacob S, Lazaro Olivia, Robertson Sylvia, Palkowitz Alan D, Lamb Bruce T, Richardson Timothy I, Dage Jeffrey L, Chu Shaoyou, Johnson Travis, Stancato Louis F, Syed Abdul Qadir

Optimization and Characterization of SHIP1 Ligands for Cellular Target Engagement and Activity in Alzheimer's Disease Models.

SHIP1 配体的优化和表征及其在阿尔茨海默病模型中的细胞靶点结合和活性。

Jesudason Cynthia D, Rangel-Barajas Claudia, Beach Colin J, Beck Daniel E, Caballero-Floran Isaac H, Clayton W Brent, Da Silva Lais, David Juliane C, Doolen Suzanne, Faulkner Alexandra N, Hamdani Adam K, Huhe Hasi, Huynh Kevin, Imhoff Ryan D, Javens-Wolfe June, Mason Emily R, Moussaif Mustapha, Singhal Kratika, Soni Disha M, van Buuren-Milne Matilda, Williams Sean-Paul, Angus Steven P, Chu Shaoyou, Dage Jeffrey L, Hipskind Philip A, Johnson Travis S, Kaddurah-Daouk Rima, Lamb Bruce T, Meikle Peter J, Mesecar Andrew D, Palkowitz Alan D, Quinney Sara K, Sukoff Rizzo Stacey J, Oblak Adrian L, Richardson Timothy I

Cell‐Based Phenotypic and Target Engagement Assays for the Identification of Small Molecules that Enhance Microglial Phagocytosis

基于细胞的表型和靶标结合分析用于鉴定增强小胶质细胞吞噬作用的小分子

Sihtmäe, Mariliis; Laanoja, Jüri; Blinova, Irina; Kahru, Anne; Kasemets, Kaja; Mason, Emily R; Jordi, Omar El; Chu, Shaoyou

Identification of PLCγ2 activators for the treatment of Alzheimer’s disease

鉴定用于治疗阿尔茨海默病的PLCγ2激活剂

Hawksley, J C; Clayton, Brent; Massey, Steven M; Chu, Shaoyou; Mason, Emily R; Bissel, Stephanie J; Bedford, Logan M; Rizzo, Stacey J Sukoff; Mesecar, Andrew D; Kaiser, Bridget L; Lendy, Emma K; Lamb, Bruce T; Palkowitz, Alan D; Richardson, Timothy I

Identification of PLCG2 activators for the treatment of Alzheimer’s disease

鉴定用于治疗阿尔茨海默病的PLCG2激活剂

Dang, Lei; Zhang, Chunbo; Su, Biru; Ning, Na; Huang, Qiuling; Zhou, Su; Wu, Meng; Ma, Wenqing; Wang, Man; Cui, Pengfei; Li, Yan; Wang, Shixuan; Clayton, Brent; Massey, Steven M; Beck, Daniel E; Putt, Karson S; Utsuki, Tada; Visvanathan, Ramya; Mesecar, Andrew D; Lendy, Emma K; Kaiser, Bridget L; Chu, Shaoyou; Mason, Emily R; Lamb, Bruce T; Palkowitz, Alan D; Richardson, Timothy I

Discovery and evaluation of novel SHIP-1 inhibitors.

新型SHIP-1抑制剂的发现与评价

Miao Jinmin, Lin Jianping, Dong Jiajun, Amarasinghe Ovini, Mason Emily R, Chu Shaoyou, Qu Zihan, Cullers Clayton C, Putt Karson S, Zhang Zhong-Yin

SHIP1 modulation and proteome characterization of microglia

SHIP1调控及小胶质细胞蛋白质组特征

Ahat, Erpan; Shi, Zanyu; Chu, Shaoyou; Bui, Hai Hoang; Mason, Emily R; Soni, Disha M; Roth, Kenneth D; Chalmers, Michael James; Oblak, Adrian L; Zhang, Jie; Gutierrez, Jesus A; Richardson, Timothy

SHIP1 therapeutic target enablement: Identification and evaluation of inhibitors for the treatment of late-onset Alzheimer's disease

SHIP1治疗靶点赋能:鉴定和评估用于治疗晚发性阿尔茨海默病的抑制剂

Jesudason, Cynthia D; Mason, Emily R; Chu, Shaoyou; Oblak, Adrian L; Javens-Wolfe, June; Moussaif, Mustapha; Durst, Greg; Hipskind, Philip; Beck, Daniel E; Dong, Jiajun; Amarasinghe, Ovini; Zhang, Zhong-Yin; Hamdani, Adam K; Singhal, Kratika; Mesecar, Andrew D; Souza, Sarah; Jacobson, Marlene; Salvo, Jerry Di; Soni, Disha M; Kandasamy, Murugesh; Masters, Andrea R; Quinney, Sara K; Doolen, Suzanne; Huhe, Hasi; Rizzo, Stacey J Sukoff; Lamb, Bruce T; Palkowitz, Alan D; Richardson, Timothy I

AD Informer Set: Chemical tools to facilitate Alzheimer's disease drug discovery

AD信息库:用于促进阿尔茨海默病药物研发的化学工具

Potjewyd, Frances M; Annor-Gyamfi, Joel K; Aubé, Jeffrey; Chu, Shaoyou; Conlon, Ivie L; Frankowski, Kevin J; Guduru, Shiva K R; Hardy, Brian P; Hopkins, Megan D; Kinoshita, Chizuru; Kireev, Dmitri B; Mason, Emily R; Moerk, Charles T; Nwogbo, Felix; Pearce, Kenneth H; Richardson, Timothy I; Rogers, David A; Soni, Disha M; Stashko, Michael; Wang, Xiaodong; Wells, Carrow; Willson, Timothy M; Frye, Stephen V; Young, Jessica E; Axtman, Alison D

Use of AD Informer Set compounds to explore validity of novel targets in Alzheimer's disease pathology

利用AD Informer Set化合物探索阿尔茨海默病病理学中新靶点的有效性

Potjewyd, Frances M; Annor-Gyamfi, Joel K; Aubé, Jeffrey; Chu, Shaoyou; Conlon, Ivie L; Frankowski, Kevin J; Guduru, Shiva K R; Hardy, Brian P; Hopkins, Megan D; Kinoshita, Chizuru; Kireev, Dmitri B; Mason, Emily R; Moerk, Charles T; Nwogbo, Felix; Pearce, Kenneth H Jr; Richardson, Timothy I; Rogers, David A; Soni, Disha M; Stashko, Michael; Wang, Xiaodong; Wells, Carrow; Willson, Timothy M; Frye, Stephen V; Young, Jessica E; Axtman, Alison D