日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Cyclin-dependent kinase 4/6 inhibitors require an arcuate-to-paraventricular hypothalamus melanocortin circuit to treat diet-induced obesity

细胞周期蛋白依赖性激酶4/6抑制剂需要弓状核-室旁核-下丘脑黑皮质素环路才能治疗饮食引起的肥胖。

Iqbal, Niloy Jafar; Schwartz, Gary J; Zhao, Hongling; Zhu, Liang; Chua, Streamson , Jr

Cutting Edge: Elevated Leptin during Diet-Induced Obesity Reduces the Efficacy of Tumor Immunotherapy

前沿研究:饮食诱导肥胖期间瘦素水平升高会降低肿瘤免疫疗法的疗效

Murphy, Katherine A; James, Britnie R; Sjaastad, Frances V; Kucaba, Tamara A; Kim, Hyunjoon; Brincks, Erik L; Chua, Streamson C Jr; Wilber, Andrew; Griffith, Thomas S

mTORC1 in AGRP neurons integrates exteroceptive and interoceptive food-related cues in the modulation of adaptive energy expenditure in mice

AGRP神经元中的mTORC1整合了外感受性和内感受性食物相关信号,从而调节小鼠的适应性能量消耗。

Burke, Luke K; Darwish, Tamana; Cavanaugh, Althea R; Virtue, Sam; Roth, Emma; Morro, Joanna; Liu, Shun-Mei; Xia, Jing; Dalley, Jeffrey W; Burling, Keith; Chua, Streamson; Vidal-Puig, Toni; Schwartz, Gary J; Blouet, Clémence

FGF 19 and Bile Acids Increase Following Roux-en-Y Gastric Bypass but Not After Medical Management in Patients with Type 2 Diabetes

2型糖尿病患者行Roux-en-Y胃旁路术后,FGF 19和胆汁酸水平升高,但药物治疗后未见升高。

Sachdev, Saachi; Wang, Qi; Billington, Charles; Connett, John; Ahmed, Leaque; Inabnet, William; Chua, Streamson; Ikramuddin, Sayeed; Korner, Judith

Leptin potentiates astrogenesis in the developing hypothalamus.

瘦素可促进发育中下丘脑的星形胶质细胞生成

Rottkamp Daniele M, Rudenko Ivan A, Maier Matthew T, Roshanbin Sahar, Yulyaningsih Ernie, Perez Luz, Valdearcos Martin, Chua Streamson, Koliwad Suneil K, Xu Allison W

The antidepressant trans-2-phenylcyclopropylamine protects mice from high-fat-diet-induced obesity

抗抑郁药反式-2-苯基环丙胺可保护小鼠免受高脂饮食诱导的肥胖症的影响。

Shemesh, Adi; Abdulla, Arian; Yang, Fajun; Chua, Streamson C; Pessin, Jeffrey E; Zong, Haihong

pRb is an obesity suppressor in hypothalamus and high-fat diet inhibits pRb in this location

pRb是下丘脑中的一种肥胖抑制因子,高脂饮食会抑制该部位的pRb活性。

Lu, Zhonglei; Marcelin, Genevieve; Bauzon, Frederick; Wang, Hongbo; Fu, Hao; Dun, Siok Le; Zhao, Hongling; Li, Xiaosong; Jo, Young-Hwan; Wardlaw, Sharon; Dun, Nae; Chua, Streamson Jr; Zhu, Liang

The apoptosis inhibitor ARC alleviates the ER stress response to promote β-cell survival

凋亡抑制剂ARC可减轻内质网应激反应,从而促进β细胞存活。

McKimpson, Wendy M; Weinberger, Jeremy; Czerski, Lech; Zheng, Min; Crow, Michael T; Pessin, Jeffrey E; Chua, Streamson C Jr; Kitsis, Richard N

Selective deletion of leptin receptors in adult hippocampus induces depression-related behaviours

选择性删除成年海马体中的瘦素受体可诱发抑郁相关行为

Guo, Ming; Huang, Tung-Yi; Garza, Jacob C; Chua, Streamson C; Lu, Xin-Yun

Agouti-related peptide plays a critical role in leptin's effects on female puberty and reproduction

与刺鼠相关的肽在瘦素对女性青春期和生殖的影响中起着关键作用

Sheffer-Babila, Sharone; Sun, Yan; Israel, Davelene D; Liu, Shun-Mei; Neal-Perry, Genevieve; Chua, Streamson C Jr