DUSP6 ablation restores CAR T-cell fitness impaired by tumor CD58 loss through invigoration of AP-1 signaling
DUSP6 消融可通过增强 AP-1 信号传导来恢复因肿瘤 CD58 丢失而受损的 CAR T 细胞活性。
期刊:Signal Transduction and Targeted Therapy
影响因子:52.7
doi:10.1038/s41392-026-02597-5
Ma, Xinran; Zhang, Yang; Wang, Yao; Han, Fuxin; Lu, Yuting; Tong, Chuan; Guo, Yelei; Wei, Jianshu; Zhu, Qi; Dong, Liang; Cao, Zhi; Meng, Zhenzhen; Shi, Jinhong; Wu, Zhiqiang; Han, Weidong
肿瘤
T细胞
CD5
肿瘤免疫
信号转导
CD58
细胞生物学
