日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

An antibody-drug conjugate designed through clone and isotype selection restricts the growth of CSPG4-expressing triple-negative breast cancer

通过克隆和同型选择设计的抗体药物偶联物可抑制表达CSPG4的三阴性乳腺癌的生长。

Esapa, Benjamina; Liu, Yi; Chenoweth, Alicia M; Stoker, Katie; Łabędź, Natalia; Romero-Clavijo, Pablo; Ilieva, Kristina M; Trendell, Jennifer; Navarro-Llinas, Blanca; Suriawinata, Erin; Butcher, Tobias; Wang, Ning; Grandits, Melanie; Palhares, Lais C G F; McCraw, Alexandra; Crescioli, Silvia; Johansson, Annelie; Irshad, Sheeba; Grigoriadis, Anita; Gazinska, Patrycja; Tsoka, Sophia; Chudasama, Vijay; Baker, James R; Tutt, Andrew N J; Cheung, Anthony; Thurston, David E; Karagiannis, Sophia N

Enabling the synthesis of multi-payload thio-antibody conjugates through the use of pyridazinediones, p-anisidine derivatives and various click chemistries

利用哒嗪二酮、对茴香胺衍生物和各种点击化学方法,实现了多有效载荷硫代抗体偶联物的合成。

McMahon, Clíona; Queval, Christophe J; Thanasi, Ioanna A; Lau, Dawn H W; Howell, Michael; Wang, Ning; Lee, Maximillian T W; Gaynord, Josephine S; Baker, James R; Chudasama, Vijay

Triggered "Capture-and-Release" Enables a High-Affinity Rebinding Strategy for Sensitivity Enhancement in Lateral Flow Assays

触发式“捕获-释放”技术实现了高亲和力重结合策略,从而提高了侧向流动检测的灵敏度

Ho, Chapman; McMahon, Clíona; Ayrton, John-Paul; Chudasama, Vijay; Thomas, Michael R

Formation of mono- and dual-labelled antibody fragment conjugates via reversible site-selective disulfide modification and proximity induced lysine reactivity

通过可逆位点选择性二硫键修饰和邻近诱导的赖氨酸反应性形成单标记和双标记抗体片段缀合物

Thanasi, Ioanna A; Bouloc, Nathalie; McMahon, Clíona; Wang, Ning; Szijj, Peter A; Butcher, Tobias; Rochet, Léa N C; Love, Elizabeth A; Merritt, Andy; Baker, James R; Chudasama, Vijay

Mass spectrometric imaging and quantitative analysis of the in vivo biodistribution of trastuzumab using a rhodium(iii) sarcophagine complex

利用铑(III)肉棺复合物进行质谱成像和定量分析,研究曲妥珠单抗在体内的生物分布。

Patel, Natasha; Pham, Truc T; Banu, Arshiya; Griffiths, Alex; Paterson, Brett M; Firth, George; Morrell, Alexander; McMahon, Clíona; Long, Nicholas J; Baker, James R; Chudasama, Vijay; Ma, Michelle T

Modular Synthesis of Semiconducting Graft Copolymers to Achieve "Clickable" Fluorescent Nanoparticles with Long Circulation and Specific Cancer Targeting

利用模块化合成半导体接枝共聚物制备具有长循环时间和特异性癌症靶向性的“可点击”荧光纳米粒子

Creamer, Adam; Fiego, Alessandra Lo; Agliano, Alice; Prados-Martin, Lino; Høgset, Håkon; Najer, Adrian; Richards, Daniel A; Wojciechowski, Jonathan P; Foote, James E J; Kim, Nayoung; Monahan, Amy; Tang, Jiaqing; Shamsabadi, André; Rochet, Léa N C; Thanasi, Ioanna A; de la Ballina, Laura R; Rapley, Charlotte L; Turnock, Stephen; Love, Elizabeth A; Bugeon, Laurence; Dallman, Margaret J; Heeney, Martin; Kramer-Marek, Gabriela; Chudasama, Vijay; Fenaroli, Federico; Stevens, Molly M

The Nitrile Bis-Thiol Bioconjugation Reaction

腈双硫醇生物偶联反应

Patel, Mikesh; Forte, Nafsika; Bishop, Charlie R; Porter, Michael J; Dagwell, Matthew; Karu, Kersti; Chudasama, Vijay; Baker, James R

Chemo- and regio-selective differential modification of native cysteines on an antibody via the use of dehydroalanine forming reagents

利用脱氢丙氨酸形成试剂对抗体上的天然半胱氨酸进行化学和区域选择性差异修饰

Yap, Steven Y; Butcher, Tobias; Spears, Richard J; McMahon, Clíona; Thanasi, Ioanna A; Baker, James R; Chudasama, Vijay

Site-directed conjugation of single-stranded DNA to affinity proteins: quantifying the importance of conjugation strategy

单链DNA与亲和蛋白的定点偶联:量化偶联策略的重要性

Rocha Tapia, Andres; Abgottspon, Fabrice; Nilvebrant, Johan; Nygren, Per-Åke; Duclos Ivetich, Sarah; Bello Hernandez, Andres Javier; Thanasi, Ioanna A; Szijj, Peter A; Sekkat, Ghali; Cuenot, François M; Chudasama, Vijay; Aceto, Nicola; deMello, Andrew J; Richards, Daniel A

An Albumin-Holliday Junction Biomolecular Modular Design for Programmable Multifunctionality and Prolonged Circulation.

一种用于可编程多功能性和延长循环寿命的白蛋白-霍利迪连接生物分子模块化设计

Dinesen Anders, Andersen Veronica L, Elkhashab Marwa, Pilati Diego, Bech Pernille, Fuchs Elisabeth, Samuelsen Torbjørn R, Winther Alexander, Cai Yunpeng, Märcher Anders, Wall Archie, Omer Marjan, Nielsen Jesper S, Chudasama Vijay, Baker James R, Gothelf Kurt V, Wengel Jesper, Kjems Jørgen, Howard Kenneth A