日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

USP2 promotes metabolic dysfunction-associated steatotic liver disease progression via stabilization of PPARγ

USP2通过稳定PPARγ促进代谢功能障碍相关的脂肪肝疾病进展。

Luo, Hao; Zhu, Chujiao; Wang, Yingying; Dai, Yidong; Hao, Peng; Cai, Haiyan; Bai, Wenhui; Zhang, Zhenge; Wan, Jiale; Zhang, Youping; Sun, Yun; Zhang, Ziwei; Wu, Yunzhao; Zhai, Yuanhui; Wu, Wenxuan; Lei, Hu; Xu, Hanzhang; He, Ming; Wu, Yingli

USP7 sustains hematopoietic stem cell homeostasis partially via PU.1 stabilization.

USP7 通过 PU.1 稳定作用部分维持造血干细胞稳态。

Shan Huizhuang, Zhang Youping, Xiao Xinhua, Wu Wenxuan, Wang Yingying, Zhu Chujiao, Bai Wenhui, Zhang Ziwei, Zhai Yuanhui, Yang Li, Wu Yunzhao, Lei Hu, Xu Hanzhang, Luo Yanfei, Lu Liming, Wu Yingli

CRISPR-Cas9 screening identifies ATOX1-driven cisplatin resistance mechanisms in liver cancer and evaluates targeted inhibitor efficacy.

CRISPR-Cas9 筛选可识别肝癌中由 ATOX1 驱动的顺铂耐药机制,并评估靶向抑制剂的疗效。

Hu Chujiao, Tai Huading, Zhu Renguang, Shu Zhengyu, Guo Guanghao, Ma Dan, Zuo Shi, Tang Lei, Zeng Zhirui

Noscapine derivative 428 suppresses ferroptosis through targeting GPX4.

诺斯卡品衍生物 428 通过靶向 GPX4 抑制铁死亡

Zhang Youping, Shi Haoliang, Wang Yingying, Liu Wanting, Li Guanyi, Li Defeng, Wu Wenxuan, Wu Yunzhao, Zhang Ziwei, Ji Yanjie, Zhu Chujiao, Bai Wenhui, Lei Hu, Xu Hanzhang, Zhong Hua, Han Baohui, Yang Li, Liu Ligen, Wang Wei, Zhao Yaxue, Zhang Yongqiang, Wu Yingli

Whole-gene CRISPR/cas9 library screen revealed targeting STAT6 increased the sensitivity of liver cancer to celecoxib via inhibiting arachidonic acid shunting.

全基因 CRISPR/Cas9 文库筛选显示,靶向 STAT6 可通过抑制花生四烯酸分流来提高肝癌对塞来昔布的敏感性

Hu Chujiao, Zeng Zhirui, Bao Xin, Li Dahuan, Tai Huading, Zeng Haohao, Luo Cheng, Tang Lei, Chen Tengxiang, Zuo Shi

Targeting USP2 induces degradation of PML-RARα with or without drug-resistant mutations in acute promyelocytic leukemia.

靶向 USP2 可诱导急性早幼粒细胞白血病中 PML-RARα 的降解,无论是否存在耐药突变。

Zhang Jie, Wu Wenxuan, Wang Yun, Zhang Youping, Wang Yingying, Bai Wenhui, Zhang Zhenge, Zhu Chujiao, Wu Yunzhao, Zhang Ziwei, Yang Li, Lei Hu, Xu Hanzhang, Zhou Li, Wu Yingli

Identification of USP2 as a novel target to induce degradation of KRAS in myeloma cells.

鉴定出 USP2 是诱导骨髓瘤细胞中 KRAS 降解的新靶点

Wang Yingying, Zhang Youping, Luo Hao, Wei Wei, Liu Wanting, Wang Weiwei, Wu Yunzhao, Peng Cheng, Ji Yanjie, Zhang Jianfang, Zhu Chujiao, Bai Wenhui, Xia Li, Lei Hu, Xu Hanzhang, Yin Leimiao, Weng Wei, Yang Li, Liu Ligen, Zhou Aiwu, Wei Yueyue, Zhu Qi, Zhu Weiliang, Yang Yongqing, Xu Zhijian, Wu Yingli

HDAC6-dependent deacetylation of NGF dictates its ubiquitination and maintains primordial follicle dormancy

HDAC6 依赖的 NGF 去乙酰化决定了其泛素化并维持原始卵泡休眠

Tuo Zhang, Yuntong Tong, Rengguang Zhu, Yaoyun Liang, Jixian Zhang, Chujiao Hu, Meina He, Zhu Hu, Zhiyi Shen, Jin Niu, Jingjing Zhang, Yuanyuan Yu, Bangming Jin, Shan Lei, Zhirui Zeng, Yingmin Wu, Zengmei Cheng, Ziwen Xiao, Bing Guo, Shuyun Zhao, Guoqiang Xu, Wei Pan, Tengxiang Chen

Engineering a targeted and safe bone anabolic gene therapy to treat osteoporosis in alveolar bone loss

设计一种有针对性的、安全的骨合成代谢基因疗法来治疗牙槽骨丢失引起的骨质疏松症

Chujiao Lin, Yeon-Suk Yang, Hong Ma, Zhihao Chen, Dong Chen, Aijaz Ahmad John, Jun Xie, Guangping Gao, Jae-Hyuck Shim

Ubiquitin-specific protease 14 targets PFKL-mediated glycolysis to promote the proliferation and migration of oral squamous cell carcinoma

泛素特异性蛋白酶14靶向PFKL介导的糖酵解促进口腔鳞状细胞癌的增殖和迁移

Xingming Zhang #, Lou Geng #, Yi Tang, Yingying Wang, Youping Zhang, Chujiao Zhu, Hu Lei, Hanzhang Xu, Qi Zhu, Yingli Wu, Wenli Gu