日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Rare bioactive tau oligomers from Alzheimer brain support both templated misfolding and fibril formation

来自阿尔茨海默病患者脑组织的罕见生物活性tau蛋白寡聚体既支持模板化错误折叠,也支持原纤维形成。

Quittot, Noé; Sivasankaran, Dhanush; Boeken, Dorothea; Chen, Yu; Chun, Joshua E; Wiedmer, Anne; Derosla, Victoria; Martins, Mariana B M S; Brooks, Forest A; Meisl, Georg; Cotton, Matthew; Arumuganainar, Durga G; Connors, Theresa; Melloni, Alexandra; Frosch, Mathew; Oakley, Derek; Makowski, Lee; Wanunu, Meni; Klenerman, David; Hyman, Bradley T

Alzheimer proteopathic tau seeds are biochemically a forme fruste of mature paired helical filaments.

阿尔茨海默病蛋白病变 tau 种子在生化上是成熟成对螺旋丝的不完全形式

Kumar Mukesh, Quittot Noé, Dujardin Simon, Schlaffner Christoph N, Viode Arthur, Wiedmer Anne, Beerepoot Pieter, Chun Joshua E, Glynn Calina, Fernandes Analiese R, Donahue Cameron, Steen Judith A, Hyman Bradley T

Reconstitution of the Alzheimer's Disease Tau Core Structure from Recombinant Tau(297-391) Yields Variable Quaternary Structures as Seen by Negative Stain and Cryo-EM

利用重组Tau(297-391)重建阿尔茨海默病Tau蛋白核心结构,通过负染和冷冻电镜观察,可获得不同的四级结构。

Glynn, Calina; Chun, Joshua E; Donahue, Cameron C; Nadler, Monica J S; Fan, Zhanyun; Hyman, Bradley T