PEAKS activation by PROTAC EPIC-0726 potentiates temozolomide in glioblastoma via K63/K48 ubiquitination-dependent ERK/AKT suppression and p21 stabilization
PROTAC EPIC-0726 通过 K63/K48 泛素化依赖的 ERK/AKT 抑制和 p21 稳定增强 PEAKS 激活,从而增强替莫唑胺在胶质母细胞瘤中的疗效。
期刊:Neuro-Oncology
影响因子:13.4
doi:10.1093/neuonc/noaf253
Hong, Biao; Su, Dongyuan; Cui, Xiaoteng; Zhao, Jixing; Wang, Qixue; Zhan, Qi; Yang, Eryan; Yang, Shixue; Ju, Jiasheng; Huang, Yanping; Cheng, Chunchao; Ding, Yaqing; Xu, Hanyi; Cui, Longtao; Zhao, Yilin; Zhao, Xun; Liang, Siwen; Liu, Yuhao; Kang, Chunsheng