日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

SARS-CoV-2 Productively Infects Human Hepatocytes and Induces Cell Death

SARS-CoV-2 有效感染人类肝细胞并诱导细胞死亡

Chunkyu Ko, Cho-Chin Cheng, Daniele Mistretta, Shubhankar Ambike, Julia Sacherl, Stoyan Velkov, Bo-Hung Liao, Romina Bester, Merve Gültan, Olga Polezhaeva, Alexander Herrmann, Constanze A Jakwerth, Carsten B Schmidt-Weber, Joachim J Bugert, Roman Wölfel, Vincent Grass, Sandra Essbauer, Daniel Schnep

No Remdesivir Resistance Observed in the Phase 3 Severe and Moderate COVID-19 SIMPLE Trials

在 3 期重度和中度 COVID-19 SIMPLE 试验中未观察到瑞德西韦耐药性

Charlotte Hedskog, Christoph D Spinner, Ulrike Protzer, Dieter Hoffmann, Chunkyu Ko, Robert L Gottlieb, Medhat Askar, Meta Roestenberg, Jutte J C de Vries, Ellen C Carbo, Ross Martin, Jiani Li, Dong Han, Lauren Rodriguez, Aiyappa Parvangada, Jason K Perry, Ricard Ferrer, Andrés Antón, Cristina André

Miniaturized Modular Click Chemistry-enabled Rapid Discovery of Unique SARS-CoV-2 Mpro Inhibitors With Robust Potency and Drug-like Profile

利用微型模块化点击化学快速发现具有强大药效和类药物特性的独特 SARS-CoV-2 Mpro 抑制剂

Mianling Yang, Myoung Kyu Lee, Shenghua Gao, Letian Song, Hye-Yeon Jang, Inseong Jo, Chun-Chiao Yang, Katharina Sylvester, Chunkyu Ko, Shuo Wang, Bing Ye, Kai Tang, Junyi Li, Manyu Gu, Christa E Müller, Norbert Sträter, Xinyong Liu, Meehyein Kim, Peng Zhan

Identification of amino acids restricting HBV receptor function in porcine NTCP

鉴定限制猪NTCP中HBV受体功能的氨基酸

Jeske, Samuel D; Wettengel, Jochen M; Gegenfurtner, Florian; Fischer, Konrad; Moosmüller, Judith; Chakraborty, Anindita; Ko, Chunkyu; Burwitz, Benjamin J; Schnieke, Angelika; Protzer, Ulrike

Quantification of the hepatitis B virus cccDNA: evidence-based guidelines for monitoring the key obstacle of HBV cure

乙型肝炎病毒cccDNA定量:监测乙肝治愈关键障碍的循证指南

Allweiss, Lena; Testoni, Barbara; Yu, Mei; Lucifora, Julie; Ko, Chunkyu; Qu, Bingqian; Lütgehetmann, Marc; Guo, Haitao; Urban, Stephan; Fletcher, Simon P; Protzer, Ulrike; Levrero, Massimo; Zoulim, Fabien; Dandri, Maura

SUMO Modification of Hepatitis B Virus Core Mediates Nuclear Entry, Promyelocytic Leukemia Nuclear Body Association, and Efficient Formation of Covalently Closed Circular DNA

乙肝病毒核心的 SUMO 修饰介导核进入、早幼粒细胞白血病核小体结合以及共价闭合环状 DNA 的有效形成

Samuel Hofmann, Verena Plank, Peter Groitl, Nathalie Skvorc, Katharina Hofmann, Julius Luther, Chunkyu Ko, Peter Zimmerman, Volker Bruss, Daniela Stadler, Arnaud Carpentier, Shahinda Rezk, Michael Nassal, Ulrike Protzer, Sabrina Schreiner

Targeting genomic SARS-CoV-2 RNA with siRNAs allows efficient inhibition of viral replication and spread

利用 siRNA 靶向基因组 SARS-CoV-2 RNA 可以有效抑制病毒复制和传播

Shubhankar Ambike, Cho-Chin Cheng, Martin Feuerherd, Stoyan Velkov, Domizia Baldassi, Suliman Qadir Afridi, Diana Porras-Gonzalez, Xin Wei, Philipp Hagen, Nikolaus Kneidinger, Mircea Gabriel Stoleriu, Vincent Grass, Gerald Burgstaller, Andreas Pichlmair, Olivia M Merkel, Chunkyu Ko, Thomas Michler

Interferon-induced degradation of the persistent hepatitis B virus cccDNA form depends on ISG20

干扰素诱导的持续性乙型肝炎病毒 cccDNA 形式的降解依赖于 ISG20

Daniela Stadler ,Martin Kächele ,Alisha N Jones ,Julia Hess ,Christian Urban ,Jessica Schneider ,Yuchen Xia ,Andreas Oswald ,Firat Nebioglu ,Romina Bester ,Felix Lasitschka ,Marc Ringelhan ,Chunkyu Ko ,Wen-Min Chou ,Arie Geerlof ,Maarten A van de Klundert ,Jochen M Wettengel ,Peter Schirmacher ,Mathias Heikenwälder ,Sabrina Schreiner ,Ralf Bartenschlager ,Andreas Pichlmair ,Michael Sattler ,Kristian Unger ,Ulrike Protzer

A PCR assay to quantify patterns of HBV transcription

一种用于定量分析HBV转录模式的PCR检测方法

D'Arienzo, Valentina; Magri, Andrea; Harris, James M; Wing, Peter A C; Ko, Chunkyu; Rubio, Claudia Orbegozo; Revill, Peter A; Protzer, Ulrike; Balfe, Peter; McKeating, Jane A

In Vivo Bioluminescence Imaging of HBV Replicating Hepatocytes Allows for the Monitoring of Anti-Viral Immunity

利用体内生物发光成像技术对HBV复制的肝细胞进行成像,可以监测抗病毒免疫力。

Manske, Katrin; Schneider, Annika; Ko, Chunkyu; Knolle, Percy A; Steiger, Katja; Protzer, Ulrike; Wohlleber, Dirk