Discovery of marinopyrrole A (maritoclax) as a selective Mcl-1 antagonist that overcomes ABT-737 resistance by binding to and targeting Mcl-1 for proteasomal degradation
发现马里诺吡咯 A (maritoclax) 是一种选择性 Mcl-1 拮抗剂,可通过结合并靶向 Mcl-1 进行蛋白酶体降解来克服 ABT-737 耐药性
期刊:Journal of Biological Chemistry
影响因子:4
doi:10.1074/jbc.M111.334532
Kenichiro Doi, Rongshi Li, Shen-Shu Sung, Hongwei Wu, Yan Liu, Wanda Manieri, Gowdahalli Krishnegowda, Andy Awwad, Alden Dewey, Xin Liu, Shantu Amin, Chunwei Cheng, Yong Qin, Ernst Schonbrunn, Gary Daughdrill, Thomas P Loughran Jr, Said Sebti, Hong-Gang Wang