日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Examination of betahistine bioavailability in combination with the monoamine oxidase B inhibitor, selegiline, in humans-a non-randomized, single-sequence, two-period titration, open label single-center phase 1 study (PK-BeST)

在人体中检验倍他司汀与单胺氧化酶 B 抑制剂司来吉兰联合用药的生物利用度——一项非随机、单序列、两周期滴定、开放标签、单中心 1 期研究 (PK-BeST)

Strupp, Michael; Churchill, Grant C; Naumann, Ivonne; Mansmann, Ulrich; Al Tawil, Amani; Golentsova, Anastasia; Goldschagg, Nicolina

Patient fibroblast circadian rhythms predict lithium sensitivity in bipolar disorder

患者成纤维细胞昼夜节律可预测双相情感障碍患者的锂敏感性

Sanghani, Harshmeena R; Jagannath, Aarti; Humberstone, Thomas; Ebrahimjee, Farid; Thomas, Justyn M; Churchill, Grant C; Cipriani, Andrea; Attenburrow, Mary-Jane; Perestenko, Olga V; Cowley, Sally A; Cader, M Zameel; Peirson, Stuart N; Harrison, Paul J; Foster, Russell G; Goodwin, Guy M; Vasudevan, Sridhar R

Defective platelet function in Niemann-Pick disease type C1

尼曼-匹克病C1型血小板功能缺陷

Chen, Oscar C W; Colaco, Alexandria; Davis, Lianne C; Kiskin, Fedir N; Farhat, Nicole Y; Speak, Anneliese O; Smith, David A; Morris, Lauren; Eden, Emily; Tynan, Patricia; Churchill, Grant C; Galione, Antony; Porter, Forbes D; Platt, Frances M

Endoplasmic reticulum and lysosomal Ca²⁺ stores are remodelled in GBA1-linked Parkinson disease patient fibroblasts

在GBA1相关帕金森病患者的成纤维细胞中,内质网和溶酶体Ca²⁺储存发生重塑。

Kilpatrick, Bethan S; Magalhaes, Joana; Beavan, Michelle S; McNeill, Alisdair; Gegg, Matthew E; Cleeter, Michael W J; Bloor-Young, Duncan; Churchill, Grant C; Duchen, Michael R; Schapira, Anthony H; Patel, Sandip

Effects of the potential lithium-mimetic, ebselen, on brain neurochemistry: a magnetic resonance spectroscopy study at 7 tesla

潜在锂模拟物依布硒仑对脑神经化学的影响:7特斯拉磁共振波谱研究

Masaki, Charles; Sharpley, Ann L; Godlewska, Beata R; Berrington, Adam; Hashimoto, Tasuku; Singh, Nisha; Vasudevan, Sridhar R; Emir, Uzay E; Churchill, Grant C; Cowen, Philip J

Effects of the potential lithium-mimetic, ebselen, on impulsivity and emotional processing

潜在的锂类似物依布硒仑对冲动性和情绪加工的影响

Masaki, Charles; Sharpley, Ann L; Cooper, Charlotte M; Godlewska, Beata R; Singh, Nisha; Vasudevan, Sridhar R; Harmer, Catherine J; Churchill, Grant C; Sharp, Trevor; Rogers, Robert D; Cowen, Philip J

Release of calcium from endolysosomes increases calcium influx through N-type calcium channels: Evidence for acidic store-operated calcium entry in neurons

内溶酶体释放钙离子会增加通过N型钙通道的钙离子内流:神经元中酸性储存操纵性钙离子内流的证据

Hui, Liang; Geiger, Nicholas H; Bloor-Young, Duncan; Churchill, Grant C; Geiger, Jonathan D; Chen, Xuesong

Two-pore Channels (TPC2s) and Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) at Lysosomal-Sarcoplasmic Reticular Junctions Contribute to Acute and Chronic β-Adrenoceptor Signaling in the Heart

溶酶体-肌浆网连接处的双孔通道(TPC2)和烟酸腺嘌呤二核苷酸磷酸(NAADP)参与心脏中的急性和慢性β-肾上腺素受体信号传导

Capel, Rebecca A; Bolton, Emma L; Lin, Wee K; Aston, Daniel; Wang, Yanwen; Liu, Wei; Wang, Xin; Burton, Rebecca-Ann B; Bloor-Young, Duncan; Shade, Kai-Ting; Ruas, Margarida; Parrington, John; Churchill, Grant C; Lei, Ming; Galione, Antony; Terrar, Derek A

Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and Endolysosomal Two-pore Channels Modulate Membrane Excitability and Stimulus-Secretion Coupling in Mouse Pancreatic β Cells

烟酸腺嘌呤二核苷酸磷酸(NAADP)和内溶酶体双孔通道调节小鼠胰岛β细胞的膜兴奋性和刺激-分泌偶联

Arredouani, Abdelilah; Ruas, Margarida; Collins, Stephan C; Parkesh, Raman; Clough, Frederick; Pillinger, Toby; Coltart, George; Rietdorf, Katja; Royle, Andrew; Johnson, Paul; Braun, Matthias; Zhang, Quan; Sones, William; Shimomura, Kenju; Morgan, Anthony J; Lewis, Alexander M; Chuang, Kai-Ting; Tunn, Ruth; Gadea, Joaquin; Teboul, Lydia; Heister, Paula M; Tynan, Patricia W; Bellomo, Elisa A; Rutter, Guy A; Rorsman, Patrik; Churchill, Grant C; Parrington, John; Galione, Antony

Discovery of novel GPVI receptor antagonists by structure-based repurposing.

通过基于结构的重新利用发现新型GPVI受体拮抗剂

Taylor Lewis, Vasudevan Sridhar R, Jones Chris I, Gibbins Jonathan M, Churchill Grant C, Campbell R Duncan, Coxon Carmen H