日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Tandem Duplications in UBTF Create XPO1-Dependent Nuclear Export Signals that Reveal a Leukemic Therapeutic Dependency.

UBTF 中的串联重复产生 XPO1 依赖性核输出信号,揭示白血病治疗依赖性。

Barajas Juan M, Phillips Aaron H, Wang Jina, Thomas Melvin E 3rd, Contreras Lisett, Umeda Masayuki, Hiltenbrand Ryan, Caldwell Elizabeth, Walsh Michael P, Song Guangchun, Ezzell Lauren, Churion Kelly, Westover Tamara, Xiong Emily, Rolle Chandra, Moore Jamila, Lott Josi, Radko-Juettner Sandi, Kumar Amit, Qi Wenjie, Xu Beisi, Papachristou Evangelia K, D'Santos Clive S, Ma Jing, Freeman Burgess B 3rd, Janke Laura J, Kriwacki Richard W, Klco Jeffery M

Brewed Coffee and Its Components Act Through Orphan Nuclear Receptor 4A1 (NR4A1).

冲泡咖啡及其成分通过孤儿核受体 4A1 (NR4A1) 发挥作用。

Hailemariam Amanuel, Upadhyay Srijana, Oany Arafat Rahman, Tsui Wai Ning Tiffany, Srivastava Vinod, Sivaram Gargi, Churion Kelly, Chapkin Robert S, Davidson Laurie A, Eitan Shoshana, Cai James J, Norton Roger, Safe Stephen

AI-Enhanced Adaptive Virtual Screening Platform Enabling Exploration of 69 Billion Molecules Discovers Structurally Validated FSP1 Inhibitors

AI增强型自适应虚拟筛选平台可探索690亿个分子,并发现结构验证的FSP1抑制剂

Cecchini, Domiziana; Nigam, AkshatKumar; Tang, Ming; Reis, Joana; Koop, Matt; Gottinger, Andrea; Nicoll, Callum Robert; Wang, Yao; Jayaraj, Abhilash; Çınaroğlu, Süleyman Selim; Törner, Ricarda; Malets, Yehor; Gehev, Minko; Das, Krishna M Padmanabha; Churion, Kelly; Kim, Jongwan; Thomas, Nidhin; Li, Yong; Seo, Hyuk-Soo; Dhe-Paganon, Sirano; Secker, Christopher; Haddadnia, Mohammad; Hasson, Alexander; Li, Minkai; Kumar, Abhishek; Levin-Konigsberg, Roni; Choi, Eun-Bee; Shapiro, Geoffrey I; Cox, Huel; Sebastian, Luke; Braithwaite, Chelsea; Bashyal, Puspalata; Radchenko, Dmytro S; Kumar, Aditya; Yang, Lei; Aquilanti, Pierre-Yves; Gabb, Henry; Alhossary, Amr; Wagner, Gerhard; Aspuru-Guzik, Alán; Moroz, Yurii S; Kalodimos, Charalampos G; Fackeldey, Konstantin; Schuetz, John D; Mattevi, Andrea; Arthanari, Haribabu; Gorgulla, Christoph

The equilibrium between two quaternary assembly states determines the activity of SPOP and its cancer mutants

两种四级组装状态之间的平衡决定了SPOP及其癌症突变体的活性。

Cuneo, Matthew J; Güllülü, Ömer; Ammar, Mohamed-Raafet; Gui, Xinrui; Churion, Kelly; Turk, Martin; O'Flynn, Brian G; Sabri, Nafiseh; Mittag, Tanja

Structural and functional insights into the interaction between the bacteriophage T4 DNA processing proteins gp32 and Dda

对噬菌体T4 DNA加工蛋白gp32和Dda相互作用的结构和功能研究

He, Xiaoping; Yun, Mi-Kyung; Li, Zhenmei; Waddell, M Brett; Nourse, Amanda; Churion, Kelly A; Kreuzer, Kenneth N; Byrd, Alicia K; White, Stephen W

Staphylococcus epidermidis ST2 strains associated with bloodstream infections contain a unique mobile genetic element encoding a plasmin inhibitor

与血流感染相关的表皮葡萄球菌 ST2 菌株含有一种独特的移动遗传元件,可编码纤溶酶抑制剂

Amy A Gomez #, Clara Kjerfve #, Minseo Choi, Wen Liu, Kelly Churion, Sheila Thomas, Holger Rohde, Sam Shelburne, Jon T Skare, Magnus Hook, Srishtee Arora

Chemical genetic analysis of enoxolone inhibition of Clostridioides difficile toxin production reveals adenine deaminase and ATP synthase as antivirulence targets

对依诺酮抑制艰难梭菌毒素产生的化学遗传学分析表明,腺嘌呤脱氨酶和ATP合酶是其抗毒力靶点。

Marreddy, Ravi K R; Phelps, Gregory A; Churion, Kelly; Picker, Jonathan; Powell, Reid; Cherian, Philip T; Bowling, John J; Stephan, Clifford C; Lee, Richard E; Hurdle, Julian G

A "Goldilocks Zone" for Recruiting BET Proteins with Bromodomain-1-Selective Ligands

利用溴结构域-1选择性配体招募BET蛋白的“黄金区域”

Mohammed, Ashraf; Churion, Kelly; Danda, Adithi; Philips, Steven J; Ansari, Aseem Z

Real-time visualization of lung malignancy with needle-based confocal laser endomicroscopy during shape-sensing robotic-assisted bronchoscopy

在基于形状感知的机器人辅助支气管镜检查过程中,利用针式共聚焦激光内窥镜实时可视化肺部恶性肿瘤

Diaz-Churion, Fabiana; Yu Lee-Mateus, Alejandra; Abia-Trujillo, David; Johnson, Margaret M; Khoor, Andras; Patel, Neal M; Reisenauer, Janani; Fernandez-Bussy, Sebastian

KRAS Inhibitor that Simultaneously Inhibits Nucleotide Exchange Activity and Effector Engagement

同时抑制核苷酸交换活性和效应分子结合的KRAS抑制剂

Pagba, Cynthia V; Gupta, Amit K; Naji, Ali K; van der Hoeven, Dharini; Churion, Kelly; Liang, Xiaowen; Jakubec, Jacob; Hook, Magnus; Zuo, Yan; Martinez de Kraatz, Marisela; Frost, Jeffrey A; Gorfe, Alemayehu A