日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

KT-253, a Novel MDM2 Degrader and p53 Stabilizer, Has Superior Potency and Efficacy than MDM2 Small-Molecule Inhibitors.

KT-253 是一种新型 MDM2 降解剂和 p53 稳定剂，其效力和功效优于 MDM2 小分子抑制剂

期刊:Molecular Cancer Therapeutics
影响因子:5.5
doi:10.1158/1535-7163.MCT-24-0306
Chutake Yogesh K, Mayo Michele F, Dumont Nancy, Filiatrault Jessica, Breitkopf Susanne B, Cho Patricia, Chen Dapeng, Dixit Vaishali S, Proctor William R, Kuhn Eric W, Bollinger Martinez Sarah, McDonald Alice A, Qi Jianfeng, Hu Kan-Nian, Karnik Rahul, Growney Joseph D, Sharma Kirti, Schalm Stefanie S, Gollerkeri Ashwin M, Mainolfi Nello, Williams Juliet A, Weiss Matthew M
信号转导
MDM2
P53
发表日期：2025
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P464: PULSE DOSING OF POTENT AND SELECTIVE HETEROBIFUNCTIONAL MDM2 DEGRADER KT-253 DRIVES TUMOR REGRESSION AND DEMONSTRATES DIFFERENTIATED PHARMACOLOGY COMPARED TO P53/MDM2 SMALL MOLECULE INHIBITORS

P464：强效选择性异功能MDM2降解剂KT-253的脉冲给药可驱动肿瘤消退，并显示出与P53/MDM2小分子抑制剂不同的药理学特性

期刊:Scientific Reports
影响因子:3.9
doi:10.1038/s41598-026-47650-z
Liu, Xin-Yi; Yan, Yi-Zhi; Jiang, An-Jun; He, Wan-Ying; Fang, Ying-Yan; Li, Chao-Hui; Deng, Man-Fei; Tan, Si-Jie; Zeng, Peng; Schalm, Stefanie; Chutake, Yogesh; Breitkopf, Susanne; Mayo, Michele; Dumont, Nancy; Chen, Dapeng; Dixit, Vaishali; Karnik, Rahul; Mcdonald, Alice; Filiatrault, Jessica; Proctor, William; Qi, Frank; Hu, Kan-Nian; Weiss, Matt; Gollerkeri, Ashwin; Sharma, Kirti; D Growney, Joseph; Williams, Juliet
MDM2
肿瘤
P53
肿瘤免疫
发表日期：2023
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ΔNp63/p73 drive metastatic colonization by controlling a regenerative epithelial stem cell program in quasi-mesenchymal cancer stem cells

ΔNp63/p73 通过控制准间质癌干细胞中的再生上皮干细胞程序来驱动转移性定植

期刊:Developmental Cell
影响因子:10.7
doi:10.1016/j.devcel.2022.11.015
Arthur W Lambert ，Christopher Fiore ，Yogesh Chutake ，Elisha R Verhaar ，Patrick C Strasser ，Mei Wei Chen ，Daneyal Farouq ，Sunny Das ，Xin Li ，Elinor Ng Eaton ，Yun Zhang ，Joana Liu Donaher ，Ian Engstrom ，Ferenc Reinhardt ，Bingbing Yuan ，Sumeet Gupta ，Bruce Wollison ，Matthew Eaton ，Brian Bierie ，John Carulli ，Eric R Olson ，Matthew G Guenther ，Robert A Weinberg
p73
细胞生物学
肿瘤
干细胞
肿瘤免疫
微生物学
发育与干细胞
发表日期：2022
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Methylated and unmethylated epialleles support variegated epigenetic silencing in Friedreich ataxia

甲基化和非甲基化的表观等位基因支持弗里德赖希共济失调中表观遗传沉默的多样性。

期刊:Human Molecular Genetics
影响因子:3.2
doi:10.1093/hmg/ddaa267
Rodden, Layne N; Chutake, Yogesh K; Gilliam, Kaitlyn; Lam, Christina; Soragni, Elisabetta; Hauser, Lauren; Gilliam, Matthew; Wiley, Graham; Anderson, Michael P; Gottesfeld, Joel M; Lynch, David R; Bidichandani, Sanjay I
表观遗传
发表日期：2021
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Reversal of epigenetic promoter silencing in Friedreich ataxia by a class I histone deacetylase inhibitor

I类组蛋白去乙酰化酶抑制剂逆转弗里德赖希共济失调中的表观遗传启动子沉默

期刊:Nucleic Acids Research
影响因子:13.1
doi:10.1093/nar/gkw107
Chutake, Yogesh K; Lam, Christina C; Costello, Whitney N; Anderson, Michael P; Bidichandani, Sanjay I
乙酰化
表观遗传
发表日期：2016
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A novel GAA-repeat-expansion-based mouse model of Friedreich's ataxia

一种基于 GAA 重复扩增的新型弗里德赖希共济失调小鼠模型

期刊:Disease Models & Mechanisms
影响因子:4
doi:10.1242/dmm.018952
Sara Anjomani Virmouni, Vahid Ezzatizadeh, Chiranjeevi Sandi, Madhavi Sandi, Sahar Al-Mahdawi, Yogesh Chutake, Mark A Pook
发表日期：2015
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Epigenetic promoter silencing in Friedreich ataxia is dependent on repeat length

弗里德赖希共济失调中的表观遗传启动子沉默取决于重复序列长度

期刊:Annals of Neurology
影响因子:7.7
doi:10.1002/ana.24249
Chutake, Yogesh K; Lam, Christina; Costello, Whitney N; Anderson, Michael; Bidichandani, Sanjay I
表观遗传
发表日期：2014
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Epigenetic silencing in Friedreich ataxia is associated with depletion of CTCF (CCCTC-binding factor) and antisense transcription

弗里德赖希共济失调的表观遗传沉默与 CTCF（CCCTC 结合因子）和反义转录的耗竭有关

期刊:PLoS One
影响因子:2.9
doi:10.1371/journal.pone.0007914
Irene De Biase, Yogesh K Chutake, Paul M Rindler, Sanjay I Bidichandani
信号转导
CTCF
发表日期：2009
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