日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Antileukemia efficacy of the dual BCL2/BCL-XL inhibitor AZD0466 in acute lymphoblastic leukemia preclinical models.

双重 BCL2/BCL-XL 抑制剂 AZD0466 在急性淋巴细胞白血病临床前模型中的抗白血病疗效

Kannan Sankaranarayanan, Li Yizhen, Baran Natalia, Yang Xu, Ghotbaldini Sanaz, Zhang Tatarata Qi, Yoshimura Satoshi, Li Zhenhua, Hsiao YuChih, Balachander Srividya, Andersen Courtney L, Cidado Justin, Yu Jiyang, Jain Nitin, Yang Jun J, Konopleva Marina

Large-scale Pan-cancer Cell Line Screening Identifies Actionable and Effective Drug Combinations

大规模泛癌细胞系筛选可确定可行且有效的药物组合

Azadeh C Bashi #, Elizabeth A Coker #, Krishna C Bulusu #, Patricia Jaaks #, Claire Crafter #, Howard Lightfoot, Marta Milo, Katrina McCarten, David F Jenkins, Dieudonne van der Meer, James T Lynch, Syd Barthorpe, Courtney L Andersen, Simon T Barry, Alexandra Beck, Justin Cidado, Jacob A Gordon, Cai

Targeting MCL-1 dysregulates cell metabolism and leukemia-stroma interactions and resensitizes acute myeloid leukemia to BCL-2 inhibition

靶向 MCL-1 可失调细胞代谢和白血病-基质相互作用,并使急性髓系白血病对 BCL-2 抑制重新敏感

Bing Z Carter, Po Yee Mak, Wenjing Tao, Marc Warmoes, Philip L Lorenzi, Duncan Mak, Vivian Ruvolo, Lin Tan, Justin Cidado, Lisa Drew, Michael Andreeff

Targeting Bfl-1 via acute CDK9 inhibition overcomes intrinsic BH3-mimetic resistance in lymphomas

通过急性 CDK9 抑制靶向 Bfl-1 可克服淋巴瘤中内在的 BH3 模拟物耐药性

Scott Boiko, Theresa Proia, Maryann San Martin, Gareth P Gregory, Michelle Min Wu, Neeraj Aryal, Maureen Hattersley, Wenlin Shao, Jamal C Saeh, Stephen E Fawell, Ricky W Johnstone, Lisa Drew, Justin Cidado

A novel BH3-mimetic, AZD0466, targeting BCL-XL and BCL-2 is effective in pre-clinical models of malignant pleural mesothelioma

一种针对 BCL-XL 和 BCL-2 的新型 BH3 类似物 AZD0466 对恶性胸膜间皮瘤的临床前模型有效

Surein Arulananda, Megan O'Brien, Marco Evangelista, Laura J Jenkins, Ashleigh R Poh, Marzena Walkiewicz, Trishe Leong, John M Mariadason, Jonathan Cebon, Srividya B Balachander, Justin R Cidado, Erinna F Lee #, Thomas John #, Walter D Fairlie #

Design and optimisation of dendrimer-conjugated Bcl-2/x(L) inhibitor, AZD0466, with improved therapeutic index for cancer therapy

设计和优化树状聚合物偶联的Bcl-2/x(L)抑制剂AZD0466,以提高其在癌症治疗中的治疗指数

Patterson, Claire M; Balachander, Srividya B; Grant, Iain; Pop-Damkov, Petar; Kelly, Brian; McCoull, William; Parker, Jeremy; Giannis, Michael; Hill, Kathryn J; Gibbons, Francis D; Hennessy, Edward J; Kemmitt, Paul; Harmer, Alexander R; Gales, Sonya; Purbrick, Stuart; Redmond, Sean; Skinner, Matthew; Graham, Lorraine; Secrist, J Paul; Schuller, Alwin G; Wen, Shenghua; Adam, Ammar; Reimer, Corinne; Cidado, Justin; Wild, Martin; Gangl, Eric; Fawell, Stephen E; Saeh, Jamal; Davies, Barry R; Owen, David J; Ashford, Marianne B

Biomarker-driven strategy for MCL1 inhibition in T-cell lymphomas

基于生物标志物的MCL1抑制策略在T细胞淋巴瘤中的应用

Raphael Koch ,Amanda L Christie ,Jennifer L Crombie ,Adam C Palmer ,Deborah Plana ,Kay Shigemori ,Sara N Morrow ,Alexandria Van Scoyk ,Wenchao Wu ,Elizabeth A Brem ,J Paul Secrist ,Lisa Drew ,Alwin G Schuller ,Justin Cidado ,Anthony Letai ,David M Weinstock

Destabilization of NOXA mRNA as a common resistance mechanism to targeted therapies

NOXA mRNA不稳定是靶向治疗常见的耐药机制

Joan Montero ,Cécile Gstalder ,Daniel J Kim ,Dorota Sadowicz ,Wayne Miles ,Michael Manos ,Justin R Cidado ,J Paul Secrist ,Adriana E Tron ,Keith Flaherty ,F Stephen Hodi ,Charles H Yoon ,Anthony Letai ,David E Fisher ,Rizwan Haq

The CUL5 ubiquitin ligase complex mediates resistance to CDK9 and MCL1 inhibitors in lung cancer cells

CUL5 泛素连接酶复合物介导肺癌细胞对 CDK9 和 MCL1 抑制剂的耐药性

Shaheen Kabir, Justin Cidado, Courtney Andersen, Cortni Dick, Pei-Chun Lin, Therese Mitros, Hong Ma, Seung Hyun Baik, Matthew A Belmonte, Lisa Drew, Jacob E Corn

Cyclin-Dependent Kinase-9 Is a Therapeutic Target in MYC-Expressing Diffuse Large B-Cell Lymphoma

细胞周期蛋白依赖性激酶 9 是 MYC 表达型弥漫大 B 细胞淋巴瘤的治疗靶点

Taylor Hashiguchi #, Nur Bruss #, Scott Best, Vi Lam, Olga Danilova, Cody J Paiva, Joelle Wolf, Erin W Gilbert, Craig Y Okada, Prabhjot Kaur, Lisa Drew, Justin Cidado, Peter Hurlin, Alexey V Danilov