日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Oral obeldesivir provides postexposure protection against Marburg virus in nonhuman primates

口服奥贝地西韦可为非人灵长类动物提供暴露后针对马尔堡病毒的保护作用

Cross, Robert W; Woolsey, Courtney; Prasad, Abhishek N; Borisevich, Viktoriya; Agans, Krystle N; Deer, Daniel J; Harrison, Mack B; Dobias, Natalie S; Fenton, Karla A; Cihlar, Tomas; Nguyen, Anh-Quan; Babusis, Darius; Bannister, Roy; Vermillion, Meghan S; Chu, Victor C; Geisbert, Thomas W

The oral drug obeldesivir protects nonhuman primates against lethal Ebola virus infection.

口服药物奥贝尔地西韦可保护非人灵长类动物免受致命的埃博拉病毒感染

Woolsey Courtney, Cross Robert W, Chu Victor C, Prasad Abhishek N, Agans Krystle N, Borisevich Viktoriya, Deer Daniel J, Harrison Mack B, Martinez Jasmine K, Dobias Natalie S, Fenton Karla A, Cihlar Tomas, Nguyen Anh-Quan, Babusis Darius, Bannister Roy, Vermillion Meghan S, Geisbert Thomas W

Remdesivir postexposure prophylaxis limits measles-induced "immune amnesia" and measles antibody responses in macaques

瑞德西韦暴露后预防可限制猕猴麻疹引起的“免疫遗忘”和麻疹抗体反应

Chan, Andy Kwan Pui; Liu, Liting; Morgenlander, William R; Thakar, Manjusha; Peart Akindele, Nadine A; Brockhurst, Jacqueline; Ghimire, Shristi; Bartlett, Maggie L; Metcalf Pate, Kelly A; Chu, Victor C; Vermillion, Meghan S; Porter, Danielle P; Cihlar, Tomas; Mina, Michael J; Larman, H Benjamin; Griffin, Diane E

Impact of HIV-1 capsid polymorphisms on viral infectivity and susceptibility to lenacapavir

HIV-1衣壳多态性对病毒感染性和对来那卡帕韦敏感性的影响

Hansen, Derek; Hendricks, Matthew R; Chang, Silvia; Cai, Arthur; Perry, Jason K; Aeschbacher, Thomas; Martin, Ross; Cihlar, Tomas; Yant, Stephen R

Discovery of Lenacapavir: First-in-Class Twice-Yearly Capsid Inhibitor for HIV-1 Treatment and Pre-exposure Prophylaxis

发现莱那卡帕韦:首个用于 HIV-1 治疗和暴露前预防的每年两次给药的衣壳抑制剂

Canales, Eda; Tse, Winston; Schroeder, Scott D; Chou, Chien-Hung; Liu, Qi; Zhang, Jennifer; Lazerwith, Scott E; Morganelli, Philip; Saito, Roland D; Brizgys, Gediminas; Li, Jiayao; Wu, Qiaoyin; Graupe, Michael; Halcomb, Randall L; Desai, Manoj; Cannizzaro, Carina; Hu, Eric; Perry, Jason K; Villaseñor, Armando G; Somoza, John R; Ferrao, Ryan D; Swaminathan, S; Zheng, Jim; Lu, Bing; Mwangi, Judy; Wang, Kelly; Subramanian, Raju; Smith, Bill J; Rhodes, Gerry; Rowe, William; Sauer, Dorothea; Lad, Latesh; Papalia, Giuseppe A; Clancy, Sheila; Stepan, George J; Yu, Helen; Sakowicz, Roman; Shi, Bing; Carr, Gavin; Bam, Rujuta A; Tsai, Luong K; Singer, Eric; Hansen, Derek; Mulato, Andrew; Yant, Stephen R; Cihlar, Tomas; Link, John O

A Randomized, Blinded, Vehicle-Controlled Dose-Ranging Study to Evaluate and Characterize Remdesivir Efficacy Against Ebola Virus in Rhesus Macaques

一项随机、双盲、载体对照剂量范围研究,旨在评估和表征瑞德西韦对恒河猴埃博拉病毒的疗效

Zumbrun, Elizabeth E; Garvey, Carly B; Wells, Jay B; Lynn, Ginger C; Van Tongeren, Sean A; Steffens, Jesse T; Wetzel, Kelly S; Wetzel, Darrell L; Esham, Heather L; Garza, Nicole L; Lee, Eric D; Scruggs, Jennifer L; Rossi, Franco D; Brown, Elizabeth S; Weidner, Jessica M; Gomba, Laura M; O'Brien, Kristan A; Jay, Alexandra N; Zeng, Xiankun; Akers, Kristen S; Kallgren, Paul A; Englund, Ethan; Meinig, J Matthew; Kugelman, Jeffrey R; Moore, Joshua L; Bloomfield, Holly A; Norris, Sarah L; Bryan, Tameka; Scheuerell, Christie H; Walters, Jesse; Mollova, Nevena; Blair, Christiana; Babusis, Darius; Cihlar, Tomas; Porter, Danielle P; Singh, Bali; Hedskog, Charlotte; Bavari, Sina; Warren, Travis K; Bannister, Roy

Effect of remdesivir post-exposure prophylaxis and treatment on pathogenesis of measles in rhesus macaques

瑞德西韦暴露后预防和治疗对恒河猴麻疹发病机制的影响

Peart Akindele, Nadine A; Katamoni, Laharika Dasharath; Brockhurst, Jacqueline; Ghimire, Shristi; Suwanmanee, San; Pieterse, Lisa; Metcalf Pate, Kelly A; Bunyan, Elaine; Bannister, Roy; Cihlar, Tomas; Porter, Danielle P; Griffin, Diane E

Characterization of the Cynomolgus Macaque Model of Marburg Virus Disease and Assessment of Timing for Therapeutic Treatment Testing

食蟹猴马尔堡病毒病模型的特征分析及治疗试验时机的评估

Zumbrun, Elizabeth E; Garvey, Carly B; Wells, Jay B; Lynn, Ginger C; Van Tongeren, Sean; Steffens, Jesse T; Wetzel, Kelly S; Gomba, Laura M; O'Brien, Kristan A; Rossi, Franco D; Zeng, Xiankun; Lee, Eric D; Raymond, Jo Lynne W; Hoffman, Diana A; Jay, Alexandra N; Brown, Elizabeth S; Kallgren, Paul A; Norris, Sarah L; Cantey-Kiser, Jean; Kudiya, Humza; Arthur, Chris; Blair, Christiana; Babusis, Darius; Chu, Victor C; Singh, Bali; Bannister, Roy; Porter, Danielle P; Cihlar, Tomas; Dye, John M

Efficacy of the oral nucleoside prodrug GS-5245 (Obeldesivir) against SARS-CoV-2 and coronaviruses with pandemic potential

口服核苷前药GS-5245(奥贝地西韦)对SARS-CoV-2和具有大流行潜力的冠状病毒的疗效

Martinez, David R; Moreira, Fernando R; Zweigart, Mark R; Gully, Kendra L; De la Cruz, Gabriela; Brown, Ariane J; Adams, Lily E; Catanzaro, Nicholas; Yount, Boyd; Baric, Thomas J; Mallory, Michael L; Conrad, Helen; May, Samantha R; Dong, Stephanie; Scobey, D Trevor; Montgomery, Stephanie A; Perry, Jason; Babusis, Darius; Barrett, Kimberly T; Nguyen, Anh-Hoa; Nguyen, Anh-Quan; Kalla, Rao; Bannister, Roy; Bilello, John P; Feng, Joy Y; Cihlar, Tomas; Baric, Ralph S; Mackman, Richard L; Schäfer, Alexandra; Sheahan, Timothy P

Mutations in the SARS-CoV-2 RNA-dependent RNA polymerase confer resistance to remdesivir by distinct mechanisms

SARS-CoV-2 RNA依赖性RNA聚合酶的突变通过不同的机制赋予病毒对瑞德西韦的耐药性。

Stevens, Laura J; Pruijssers, Andrea J; Lee, Hery W; Gordon, Calvin J; Tchesnokov, Egor P; Gribble, Jennifer; George, Amelia S; Hughes, Tia M; Lu, Xiaotao; Li, Jiani; Perry, Jason K; Porter, Danielle P; Cihlar, Tomas; Sheahan, Timothy P; Baric, Ralph S; Götte, Matthias; Denison, Mark R