日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Ligand-specific activation trajectories dictate GPCR signalling in cells.

配体特异性激活轨迹决定细胞内的 GPCR 信号传导。

Thomas Romy, Jacoby Pauline S, De Faveri Chiara, Derieux Cécile, Liebing Aenne-Dorothea, Melkes Barbora, Martini Hans-Joachim, Bermúdez Marcel, Stäubert Claudia, Lohse Martin J, Coin Irene, Bock Andreas

Somatic deficiency of the human E3 ubiquitin ligase CBL in leukocytes impairs B cell but not T cell development and function.

白细胞中人类 E3 泛素连接酶 CBL 的体细胞缺陷会损害 B 细胞的发育和功能,但不会影响 T 细胞的发育和功能。

Vatovec Taja, Neehus Anna-Lena, Jackson Katherine J L, Avery Danielle T, Bagarić Ivan, Erazo Lucia, Arango-Franco Carlos A, Ogishi Masato, Ahmed Syed F, Cederholm Axel, Russell Amanda J, Della Mina Erika, Al-Rifai Dena, Bull Rowena, Buetow Lori, Sobrino Steicy, Zhang Allison, Wahlster Lara, Michelet Marine, Parvaneh Nima, Peel Jessica, Barzaghi Federica, Leardini Davide, Philippot Quentin, Saettini Francesco, Dutrieux Jacques, de Muylder Benedicte, Vendemini Francesca, Baccelli Francesco, Catala Albert, Gambineri Eleonora, Veltroni Marinella, Pandiarajan Vignesh, Aguilar Yurena, Haerynck Filomeen, Elliott Michael, Turville Stuart, Brillot Fabienne, Khan Taushif, Consonni Filippo, Berteloot Laureline, Sewell William A, Rao Geetha, Largeaud Laetitia, Conti Francesca, Roullion Cecile, Masson Cécile, Pegoraro Francesco, Ye Tianyi, Joubran Samantha, Villalpando Emily, Bessot Boris, Seeleuthner Yoann, Le Voyer Tom, Rosain Jérémie, Li Hailun, Janda Zarah, Muratore Edoardo, Soudée Camille, Delabesse Eric, Goulvestre Claire, Shahrooei Mohammad, Puel Anne, André Isabelle, Bole-Feysot Christine, Abel Laurent, Erlacher Miriam, Béziat Vivien, Lagresle-Peyrou Chantal, Cheynier Remi, Six Emmanuelle, Marr Nico, Pasquet Marlène, Alsina Laia, Goodnow Christopher C, Landegren Nils, Aiuti Alessandro, Zhang Peng, Masetti Riccardo, Huang Danny T, Ma Cindy S, Casanova Jean-Laurent, Sankaran Vijay G, Bustamante Jacinta, Tangye Stuart G, Bohlen Jonathan

EGFR inhibitor-resistant lung cancers exhibit collateral sensitivity to a covalent, cysteine-independent KEAP1 oligomerizing molecular bridge.

对 EGFR 抑制剂耐药的肺癌表现出对共价、不依赖半胱氨酸的 KEAP1 寡聚化分子桥的协同敏感性。

Bassil Christopher F, Dillon Kerry, Anderson Gray R, Mayro Benjamin, Askin Kayleigh N, Winter Peter S, Harry Stefan, Gruber Samuel, Hall Tierney M, Hoj Jacob P, Cerda-Smith Christian, Hutchinson Haley M, Killarney Shane T, Heffernan Ava, Teddy Caroline, Singleton Katherine R, Qin Li, Jubien-Girard Kévin, Favreau Cécile, Robert Guillaume, Tivon Barr, Livnah Ella, London Nir, Benhida Rachid, Auberger Patrick, Pendergast Ann Marie, Bar-Peled Liron, Lonard David M, Martin Anthony R, Puissant Alexandre, Wood Kris C

Tuning of the RBR1-E2F/DP transcriptional module by the F-box protein FBL17.

F-box 蛋白 FBL17 对 RBR1-E2F/DP 转录模块的调控。

Espanet Juliette, He Xiaoning, Pan Ting, Gentric Naomie, Potuschak Thomas, Desvoyes Bénédicte, Hammann Philippe, Chicher Johana, Brik Rim, Lechner Esther, Latrasse David, Pettkó-Szandtner Aladár, Gutierrez Crisanto, Raynaud Cécile, Magyar Zoltán, Benhamed Moussa, Yan Shunping, Noir Sandra, Genschik Pascal

Recurrent Resistance Mutations to Lirafugratinib Inform Treatment Sequencing in FGFR2-Driven Tumors.

对利拉夫格拉替尼的复发性耐药突变可指导 FGFR2 驱动肿瘤的治疗顺序。

Facchinetti Francesco, Hollebecque Antoine, Barbé Rémy, Jang Dong Man, Alonso-De-Castro Beatriz, Brayé Floriane, Bigot Ludovic, Nobre Catline, Da Silva Alice, Méteau Mélissandre, Delavigne Mathis, Soares Miguel, Italiano Antoine, Rodriguez Julieta, Mosele Fernanda, Beshiri Kristi, Ducreux Michel, Boilève Alice, Nikolaev Sergey, Alonso-Garcia Inmaculada, Vasseur Damien, Smolenschi Cristina, Bourien Héloise, Cotteret Sophie, Samaniego Juliette, Bernard Elsa, Nicotra Claudio, Ngo-Camus Maud, Nakazawa Seshiru, Tselikas Lambros, Badoual Cécile, André Fabrice, Eck Michael J, Olaussen Ken A, Loriot Yohann, Friboulet Luc

Microglial colonization of the developing mouse brain is controlled by both microglial and neural CSF-1.

小鼠发育过程中大脑中小胶质细胞的定植受小胶质细胞和神经 CSF-1 的共同控制。

Bridlance Cécile, Viguier Sarah, Olivié Nicolas, Dupont Edmond, Thobois Dorine, Mathieu Benjamin, Jiang Jean X, López-Bendito Guillermina, Greter Melanie, Becher Burkhard, Ginhoux Florent, Silvin Aymeric, Klingler Esther, Garel Sonia, Thion Morgane Sonia

The Proinflammatory Secretome of Senescent Cells Can Be Controlled by a HIF2A-Dependent Upregulation and a FURIN-Dependent Cleavage of the ANGPTL4 Secreted Factor.

衰老细胞的促炎分泌组可通过 HIF2A 依赖性上调和 FURIN 依赖性切割 ANGPTL4 分泌因子来控制。

Makulyte Gabriela, Safwan-Zaiter Hasan, Goehrig Delphine, Huna Anda, Mangelinck Adèle, Mikawa Takumi, Palazzo Alberta, Moudombi Lyvia, Medard Jean-Jacques, Chanal Marie, Lecot Pacôme, Michallet Marie-Cécile, Gavard Julie, Adnot Serge, Dubus Pierre, Kondoh Hiroshi, Mann Carl, Tan Nguan Soon, Bertolino Philippe, Flaman Jean-Michel, Bernard David

Improving angiogenesis ameliorates the efficacy of ASO-based exon skipping for the treatment of Duchenne muscular dystrophy.

改善血管生成可提高基于 ASO 的外显子跳跃治疗杜氏肌营养不良症的疗效。

Blitek Mathilde, Gastaldi Cécile, Doisy Mathilde, Le Coz Olivier, David Marion, Phongsavanh Xaysongkhame, Ben Aicha Sameh, Garcia Luis, Rotini Alessio, Pagès Gilles, Goyenvalle Aurélie

PCBP1 binding to single-stranded poly-cytosine motifs enhances cGAS sensing and impairs breast cancer development.

PCBP1 与单链多胞嘧啶基序的结合增强了 cGAS 的感知,并损害了乳腺癌的发展。

Fréreux Cécile, Karam Joseph A Q, Howley Breege V, Granger Bryan, Chakraborty Paramita, Vaena Silvia, Romeo Martin, Dalton Annamarie C, Mohanty Bidyut K, Mehrotra Shikhar, Howe Philip H

Cellular Functional Analyses of ARX Variants Reveal New Insights Into Genotype-Phenotype Correlations in Neurodevelopmental Disorders Among Male and Female Patients.

对 ARX 变异体的细胞功能分析揭示了男性和女性患者神经发育障碍中基因型-表型相关性的新见解。

Faraj Rasha, Farrugia Audrey, Hurst Anna C E, Conan Pierre, Martin Jennifer, Schalk Audrey, Redon Sylvia, Dubos Aline, Gras Mathilde, Curie Aurore, Voisset Cécile, Friocourt Gaëlle