日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A Constitutive EGFR Kinase Dimer to Study Inhibitor Pharmacology

组成型 EGFR 激酶二聚体用于研究抑制剂药理学

Justin J Kim, Ilse K Schaeffner, David E Heppner, Ciric To, Pasi A Jänne, Tyler S Beyett, Michael J Eck

Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors

ATP 位点和变构 EGFR 抑制剂协同结合和协同作用的分子基础

Tyler S Beyett #, Ciric To #, David E Heppner, Jaimin K Rana, Anna M Schmoker, Jaebong Jang, Dries J H De Clercq, Gabriel Gomez, David A Scott, Nathanael S Gray, Pasi A Jänne, Michael J Eck

Design of a "Two-in-One" Mutant-Selective Epidermal Growth Factor Receptor Inhibitor That Spans the Orthosteric and Allosteric Sites

跨越正构和变构位点的“二合一”突变选择性表皮生长因子受体抑制剂的设计

Florian Wittlinger, David E Heppner, Ciric To, Marcel Günther, Bo Hee Shin, Jaimin K Rana, Anna M Schmoker, Tyler S Beyett, Lena M Berger, Benedict-Tilman Berger, Nicolas Bauer, James D Vasta, Cesear R Corona, Matthew B Robers, Stefan Knapp, Pasi A Jänne, Michael J Eck, Stefan A Laufer

Oncogenic switch and single-agent MET inhibitor sensitivity in a subset of EGFR-mutant lung cancer

EGFR 突变肺癌亚组中致癌基因转换和单药 MET 抑制剂敏感性

Pınar Özden Eser, Raymond M Paranal, Jieun Son, Elena Ivanova, Yanan Kuang, Heidi M Haikala, Ciric To, Jeffrey J Okoro, Kshiti H Dholakia, Jihyun Choi, Yoonji Eum, Atsuko Ogino, Pavlos Missios, Dalia Ercan, Man Xu, Michael J Poitras, Stephen Wang, Kenneth Ngo, Michael Dills, Masahiko Yanagita, Timot

Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway

通过 YAP 介导的凋亡途径转录重编程,治疗诱导肿瘤休眠

Kari J Kurppa, Yao Liu, Ciric To, Tinghu Zhang, Mengyang Fan, Amir Vajdi, Erik H Knelson, Yingtian Xie, Klothilda Lim, Paloma Cejas, Andrew Portell, Patrick H Lizotte, Scott B Ficarro, Shuai Li, Ting Chen, Heidi M Haikala, Haiyun Wang, Magda Bahcall, Yang Gao, Sophia Shalhout, Steffen Boettcher, Bo

Single and Dual Targeting of Mutant EGFR with an Allosteric Inhibitor

使用变构抑制剂对突变型 EGFR 进行单靶向和双靶向治疗

Ciric To #, Jaebong Jang #, Ting Chen, Eunyoung Park, Mierzhati Mushajiang, Dries J H De Clercq, Man Xu, Stephen Wang, Michael D Cameron, David E Heppner, Bo Hee Shin, Thomas W Gero, Annan Yang, Suzanne E Dahlberg, Kwok-Kin Wong, Michael J Eck, Nathanael S Gray, Pasi A Jänne

Discovery of a potent dual ALK and EGFR T790M inhibitor

发现有效的双重 ALK 和 EGFR T790M 抑制剂

Jaebong Jang, Jung Beom Son, Ciric To, Magda Bahcall, So Young Kim, Seock Yong Kang, Mierzhati Mushajiang, Younho Lee, Pasi A Jänne, Hwan Geun Choi, Nathanael S Gray

The PARP inhibitors, veliparib and olaparib, are effective chemopreventive agents for delaying mammary tumor development in BRCA1-deficient mice

PARP 抑制剂 veliparib 和 olaparib 是有效的化学预防剂,可延缓 BRCA1 缺陷小鼠乳腺肿瘤的发展

Ciric To, Eun-Hee Kim, Darlene B Royce, Charlotte R Williams, Ryan M Collins, Renee Risingsong, Michael B Sporn, Karen T Liby