日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The polypharmacy combination of the BCL-2 inhibitor venetoclax (VEN) and the FLT3 inhibitor gilteritinib (GIL) is more active in acute myeloid leukemia cells than novel polypharmacologic BCL-2/FLT3 VEN-GIL hybrid single-molecule inhibitors

BCL-2抑制剂维奈托克(VEN)和FLT3抑制剂吉瑞替尼(GIL)的多药联合疗法在急性髓系白血病细胞中的活性高于新型多药BCL-2/FLT3 VEN-GIL混合单分子抑制剂。

Goodis, Christopher C; Eberly, Christian; Chan, Alexandria M; Kim, MinJung; Lowe, Brandon D; Civin, Curt I; Fletcher, Steven

Augmenting the Anti-Leukemic Activity of the BCL-2 Inhibitor Venetoclax Through Its Transformation Into Polypharmacologic Dual BCL-2/HDAC1 and Dual BCL-2/HDAC6 Inhibitors

通过将 BCL-2 抑制剂维奈托克转化为多药理双重 BCL-2/HDAC1 抑制剂和双重 BCL-2/HDAC6 抑制剂来增强其抗白血病活性

Alexandria M Chan ,Christian Eberly ,Brandon Drennen ,Christopher C Goodis ,Zoe Wuyts ,Curt I Civin ,Steven Fletcher

Comparative efficacy and mechanism of action of cardiac progenitor cells after cardiac injury

心脏损伤后心脏祖细胞的比较疗效和作用机制

Muthukumar Gunasekaran ,Rachana Mishra ,Progyaparamita Saha ,David Morales ,Wen-Chih Cheng ,Arun R Jayaraman ,Jessica R Hoffman ,Lauran Davidson ,Ling Chen ,Aakash M Shah ,Gregory Bittle ,Xuebin Fu ,Antariksh Tulshyan ,Mohamed Abdullah ,Tami Kingsbury ,Curt Civin ,Peixin Yang ,Michael E Davis ,Roberto Bolli ,Joshua M Hare ,Sudhish Sharma ,Sunjay Kaushal

Venetoclax and pegcrisantaspase for complex karyotype acute myeloid leukemia

维奈克拉和聚乙二醇化物蛋白酶治疗复杂核型急性髓系白血病

Ashkan Emadi, Bandish Kapadia, Dominique Bollino, Binny Bhandary, Maria R Baer, Sandrine Niyongere, Erin T Strovel, Hannah Kaizer, Elizabeth Chang, Eun Yong Choi, Xinrong Ma, Kayla M Tighe, Brandon Carter-Cooper, Blake S Moses, Curt I Civin, Anup Mahurkar, Amol C Shetty, Ronald B Gartenhaus, Farin K

Antileukemic efficacy of a potent artemisinin combined with sorafenib and venetoclax

强效青蒿素联合索拉非尼和维奈托克治疗白血病的疗效

Moses, Blake S; McCullough, Samantha; Fox, Jennifer M; Mott, Bryan T; Bentzen, Søren M; Kim, MinJung; Tyner, Jeffrey W; Lapidus, Rena G; Emadi, Ashkan; Rudek, Michelle A; Kingsbury, Tami J; Civin, Curt I

A Novel 2-Carbon-Linked Dimeric Artemisinin With Potent Antileukemic Activity and Favorable Pharmacology

一种新型的2碳连接二聚青蒿素,具有强效抗白血病活性和良好的药理学特性

Kagan, Amanda B; Moses, Blake S; Mott, Bryan T; Rai, Ganesha; Anders, Nicole M; Rudek, Michelle A; Civin, Curt I

The PAX-SIX-EYA-DACH network modulates GATA-FOG function in fly hematopoiesis and human erythropoiesis

PAX-SIX-EYA-DACH 网络调节果蝇造血和人类红细胞生成中的 GATA-FOG 功能

T Michael Creed, Rajkumar Baldeosingh, Christian L Eberly, Caroline S Schlee, MinJung Kim, Jevon A Cutler, Akhilesh Pandey, Curt I Civin, Nancy G Fossett, Tami J Kingsbury

A Fluidic Culture Platform for Spatially Patterned Cell Growth, Differentiation, and Cocultures

用于空间模式化细胞生长、分化和共培养的流体培养平台

Lembong, Josephine; Lerman, Max J; Kingsbury, Tami J; Civin, Curt I; Fisher, John P

STAT5 inhibition induces TRAIL/DR4 dependent apoptosis in peripheral T-cell lymphoma

STAT5 抑制诱导外周 T 细胞淋巴瘤中 TRAIL/DR4 依赖性细胞凋亡

Haley M Simpson, Aki Furusawa, Kavitha Sadashivaiah, Curt I Civin, Arnob Banerjee

Inefficient megakaryopoiesis in mouse hematopoietic stem-progenitor cells lacking T-bet

缺乏 T-bet 的小鼠造血干祖细胞巨核细胞生成效率低下

Aki Furusawa, Kavitha Sadashivaiah, Zeba N Singh, Curt I Civin, Arnob Banerjee