日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Autistic behavior is a common outcome of biallelic disruption of PDZD8 in humans and mice

自闭症行为是人类和小鼠中PDZD8双等位基因破坏的常见结果。

Pantiru, Andreea D; Van de Sompele, Stijn; Ligneul, Clemence; Chatelain, Camille; Barrea, Christophe; Lerch, Jason P; Filippi, Beatrice M; Alkan, Serpil; De Baere, Elfride; Johnston, Jamie; Clapcote, Steven J

Alternating Hemiplegia of Childhood and ATP1A3-Related Diseases: Insights From a Decade of Discovery and Collaboration

儿童交替性偏瘫和ATP1A3相关疾病:十年发现与合作的启示

Simpson, Alexander J; McLellan, Ailsa; Behl, Katherine Elizabeth; Brown, Jo; Clapcote, Steven J; Cross, J Helen; van den Maagdenberg, Arn M J M; Vezyroglou, Aikaterini None; Balestrini, Simona; Sisodiya, Sanjay M

Protective effect of PDE4B subtype-specific inhibition in an App knock-in mouse model for Alzheimer's disease

PDE4B 亚型特异性抑制对 App 敲入小鼠模型中阿尔茨海默病的保护作用

Paul Armstrong #, Hüseyin Güngör #, Pariya Anongjanya, Clare Tweedy, Edward Parkin, Jamie Johnston, Ian M Carr, Neil Dawson, Steven J Clapcote

PDE4B Missense Variant Increases Susceptibility to Post-traumatic Stress Disorder-Relevant Phenotypes in Mice

PDE4B 错义变异增加小鼠对创伤后应激障碍相关表型的易感性

Tatiana V Lipina, Shupeng Li, Ekaterina S Petrova, Tamara G Amstislavskaya, Ryan T Cameron, Christina Elliott, Yoichi Gondo, Alexander McGirr, Jonathan G L Mullins, George S Baillie, James R Woodgett, Steven J Clapcote

Structural and functional characterization of the IgSF21-neurexin2α complex and its related signaling pathways in the regulation of inhibitory synapse organization

IgSF21-neurexin2α复合物及其相关信号通路在调节抑制性突触组织中的结构和功能特征

Nicolas Chofflet, Yusuke Naito, Anthony John Pastore, Nirmala Padmanabhan, Phuong Trang Nguyen, Christian Poitras, Benjamin Feller, Nayoung Yi, Jeremie Van Prooijen, Husam Khaled, Benoit Coulombe, Steven J Clapcote, Steve Bourgault, Tabrez J Siddiqui, Gabby Rudenko, Hideto Takahashi

In memory of Professor Iain Wilkinson: cognitive and neuroimaging endophenotypes in a consanguineous schizophrenia multiplex family

谨以此文纪念伊恩·威尔金森教授:近亲婚配多重精神分裂症家族的认知和神经影像学内表型

Wilkinson, Iain D; Mahmood, Tariq; Yasmin, Sophia Faye; Tomlinson, Anneka; Nazari, Jamshid; Alhaj, Hamid; El Din, Soumaya Nasser; Neill, Joanna; Pandit, Chhaya; Ashraf, Shahzad; Cardno, Alastair G; Clapcote, Steven J; Inglehearn, Chris F; Woodruff, Peter W

PDZD8 Disruption Causes Cognitive Impairment in Humans, Mice, and Fruit Flies

PDZD8基因缺失会导致人类、小鼠和果蝇的认知障碍

Al-Amri, Ahmed H; Armstrong, Paul; Amici, Mascia; Ligneul, Clemence; Rouse, James; El-Asrag, Mohammed E; Pantiru, Andreea; Vancollie, Valerie E; Ng, Hannah W Y; Ogbeta, Jennifer A; Goodchild, Kirstie; Ellegood, Jacob; Lelliott, Christopher J; Mullins, Jonathan G L; Bretman, Amanda; Al-Ali, Ruslan; Beetz, Christian; Al-Gazali, Lihadh; Al Shamsi, Aisha; Lerch, Jason P; Mellor, Jack R; Al Sayegh, Abeer; Ali, Manir; Inglehearn, Chris F; Clapcote, Steven J

Altered medial prefrontal cortex and dorsal raphé activity predict genotype and correlate with abnormal learning behavior in a mouse model of autism-associated 2p16.3 deletion

在自闭症相关 2p16.3 缺失的小鼠模型中,内侧前额皮质和背缝活动的改变可预测基因型并与异常学习行为相关

Rebecca B Hughes, Jayde Whittingham-Dowd, Steven J Clapcote, Susan J Broughton, Neil Dawson

How can we obtain truly translational mouse models to improve clinical outcomes in schizophrenia?

我们如何才能获得真正具有转化意义的小鼠模型,以改善精神分裂症的临床疗效?

Clapcote, Steven J

A Recessively Inherited Risk Locus on Chromosome 13q22-31 Conferring Susceptibility to Schizophrenia

13q22-31染色体上的隐性遗传风险位点赋予精神分裂症易感性

Mahmood, Tariq; El-Asrag, Mohammed E; Poulter, James A; Cardno, Alastair G; Tomlinson, Anneka; Ahmed, Sophia; Al-Amri, Ahmed; Nazari, Jamshid; Neill, Joanna; Chamali, Rifka S; Kiwan, Nancy; Ghuloum, Suhaila; Alhaj, Hamid A; Randerson Moor, Juliette; Khan, Shabana; Al-Amin, Hassen; Johnson, Colin A; Woodruff, Peter; Wilkinson, Iain D; Ali, Manir; Clapcote, Steven J; Inglehearn, Chris F