Clapham Paul R相关文献与解析，生知库 | 链接生命科学的每一步

HIV-1 R5 Macrophage-Tropic Envelope Glycoprotein Trimers Bind CD4 with High Affinity, while the CD4 Binding Site on Non-macrophage-tropic, T-Tropic R5 Envelopes Is Occluded

HIV-1 R5 巨噬细胞嗜性包膜糖蛋白三聚体与 CD4 高亲和力结合，而非巨噬细胞嗜性、T 细胞嗜性 R5 包膜上的 CD4 结合位点则被阻断。

Quitadamo, Briana; Peters, Paul J; Repik, Alexander; O'Connell, Olivia; Mou, Zhongming; Koch, Matthew; Somasundaran, Mohan; Brody, Robin; Luzuriaga, Katherine; Wallace, Aaron; Wang, Shixia; Lu, Shan; McCauley, Sean; Luban, Jeremy; Duenas-Decamp, Maria; Gonzalez-Perez, Maria Paz; Clapham, Paul R

巨噬细胞

Ultradeep single-molecule real-time sequencing of HIV envelope reveals complete compartmentalization of highly macrophage-tropic R5 proviral variants in brain and CXCR4-using variants in immune and peripheral tissues

HIV包膜的超深度单分子实时测序揭示了高度嗜巨噬细胞的R5前病毒变体在大脑中的完全区室化，以及利用CXCR4的变体在免疫和外周组织中的完全区室化。

期刊:Journal of Neurovirology

影响因子:1.9

doi:10.1007/s13365-018-0633-5

Brese, Robin L; Gonzalez-Perez, Maria Paz; Koch, Matthew; O'Connell, Olivia; Luzuriaga, Katherine; Somasundaran, Mohan; Clapham, Paul R; Dollar, James Jarad; Nolan, David J; Rose, Rebecca; Lamers, Susanna L

Identification of Emerging Macrophage-Tropic HIV-1 R5 Variants in Brain Tissue of AIDS Patients without Severe Neurological Complications

在无严重神经系统并发症的艾滋病患者脑组织中鉴定出新出现的嗜巨噬细胞HIV-1 R5变异株

期刊:Journal of Virology

影响因子:3.8

doi:10.1128/JVI.00755-17

Gonzalez-Perez, Maria Paz; Peters, Paul J; O'Connell, Olivia; Silva, Nilsa; Harbison, Carole; Cummings Macri, Sheila; Kaliyaperumal, Saravanan; Luzuriaga, Katherine; Clapham, Paul R

Saturation Mutagenesis of the HIV-1 Envelope CD4 Binding Loop Reveals Residues Controlling Distinct Trimer Conformations

HIV-1包膜CD4结合环的饱和诱变揭示了控制不同三聚体构象的残基

期刊:PLoS Pathogens

影响因子:4.9

doi:10.1371/journal.ppat.1005988

Duenas-Decamp, Maria; Jiang, Li; Bolon, Daniel; Clapham, Paul R

Efficiency of bridging-sheet recruitment explains HIV-1 R5 envelope glycoprotein sensitivity to soluble CD4 and macrophage tropism

桥接片层募集的效率解释了HIV-1 R5包膜糖蛋白对可溶性CD4和巨噬细胞嗜性的敏感性

期刊:Journal of Virology

影响因子:3.8

doi:10.1128/JVI.01834-12

O'Connell, Olivia; Repik, Alexander; Reeves, Jacqueline D; Gonzalez-Perez, Maria Paz; Quitadamo, Briana; Anton, Elizabeth D; Duenas-Decamp, Maria; Peters, Paul; Lin, Rongheng; Zolla-Pazner, Susan; Corti, Davide; Wallace, Aaron; Wang, Shixia; Kong, Xiang-Peng; Lu, Shan; Clapham, Paul R

Independent evolution of macrophage-tropism and increased charge between HIV-1 R5 envelopes present in brain and immune tissue

脑组织和免疫组织中存在的HIV-1 R5包膜之间，巨噬细胞趋向性的独立进化和电荷增加。

期刊:Retrovirology

影响因子:3.9

doi:10.1186/1742-4690-9-20

Gonzalez-Perez, Maria Paz; O'Connell, Olivia; Lin, Rongheng; Sullivan, W Matthew; Bell, Jeanne; Simmonds, Peter; Clapham, Paul R

The W100 pocket on HIV-1 gp120 penetrated by b12 is not a target for other CD4bs monoclonal antibodies

HIV-1 gp120 上的 W100 口袋可被 b12 穿透，但并非其他 CD4 结合位点单克隆抗体的靶点。

期刊:Retrovirology

影响因子:3.9

doi:10.1186/1742-4690-9-9

Dueñas-Decamp, Maria J; O'Connell, Olivia J; Corti, Davide; Zolla-Pazner, Susan; Clapham, Paul R

Genotypic and functional properties of early infant HIV-1 envelopes

婴儿早期HIV-1包膜的基因型和功能特性

期刊:Retrovirology

影响因子:3.9

doi:10.1186/1742-4690-8-67

Kishko, Michael; Somasundaran, Mohan; Brewster, Frank; Sullivan, John L; Clapham, Paul R; Luzuriaga, Katherine

A conserved determinant in the V1 loop of HIV-1 modulates the V3 loop to prime low CD4 use and macrophage infection

HIV-1 V1环中的一个保守决定簇调节V3环，从而启动低CD4利用率和巨噬细胞感染。

期刊:Journal of Virology

影响因子:3.8

doi:10.1128/JVI.02187-10

Musich, Thomas; Peters, Paul J; Duenas-Decamp, Maria José; Gonzalez-Perez, Maria Paz; Robinson, James; Zolla-Pazner, Susan; Ball, Jonathan K; Luzuriaga, Katherine; Clapham, Paul R

Implications of the 375W mutation for HIV-1 tropism and vaccine development

375W突变对HIV-1嗜性和疫苗研发的影响

HIV-1 R5 Macrophage-Tropic Envelope Glycoprotein Trimers Bind CD4 with High Affinity, while the CD4 Binding Site on Non-macrophage-tropic, T-Tropic R5 Envelopes Is Occluded

HIV-1 R5 巨噬细胞嗜性包膜糖蛋白三聚体与 CD4 高亲和力结合，而非巨噬细胞嗜性、T 细胞嗜性 R5 包膜上的 CD4 结合位点则被阻断。

Ultradeep single-molecule real-time sequencing of HIV envelope reveals complete compartmentalization of highly macrophage-tropic R5 proviral variants in brain and CXCR4-using variants in immune and peripheral tissues

HIV包膜的超深度单分子实时测序揭示了高度嗜巨噬细胞的R5前病毒变体在大脑中的完全区室化，以及利用CXCR4的变体在免疫和外周组织中的完全区室化。

Identification of Emerging Macrophage-Tropic HIV-1 R5 Variants in Brain Tissue of AIDS Patients without Severe Neurological Complications

在无严重神经系统并发症的艾滋病患者脑组织中鉴定出新出现的嗜巨噬细胞HIV-1 R5变异株

Saturation Mutagenesis of the HIV-1 Envelope CD4 Binding Loop Reveals Residues Controlling Distinct Trimer Conformations

HIV-1包膜CD4结合环的饱和诱变揭示了控制不同三聚体构象的残基

Efficiency of bridging-sheet recruitment explains HIV-1 R5 envelope glycoprotein sensitivity to soluble CD4 and macrophage tropism

桥接片层募集的效率解释了HIV-1 R5包膜糖蛋白对可溶性CD4和巨噬细胞嗜性的敏感性

Independent evolution of macrophage-tropism and increased charge between HIV-1 R5 envelopes present in brain and immune tissue

脑组织和免疫组织中存在的HIV-1 R5包膜之间，巨噬细胞趋向性的独立进化和电荷增加。

The W100 pocket on HIV-1 gp120 penetrated by b12 is not a target for other CD4bs monoclonal antibodies

HIV-1 gp120 上的 W100 口袋可被 b12 穿透，但并非其他 CD4 结合位点单克隆抗体的靶点。

Genotypic and functional properties of early infant HIV-1 envelopes

婴儿早期HIV-1包膜的基因型和功能特性

A conserved determinant in the V1 loop of HIV-1 modulates the V3 loop to prime low CD4 use and macrophage infection

HIV-1 V1环中的一个保守决定簇调节V3环，从而启动低CD4利用率和巨噬细胞感染。