日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

ercc6 deficient zebrafish exhibit UV and metronidazole sensitivity, increased oxygen consumption, and impaired hair cell mechanoelectrical transduction which can be restored by the superoxide dismutase mimetic MnTBAP

缺乏ercc6基因的斑马鱼表现出对紫外线和甲硝唑的敏感性、耗氧量增加以及毛细胞机械电转换功能受损,而超氧化物歧化酶模拟物MnTBAP可以恢复这些功能。

Hernandez Herrera, Gabriel A; Dugdale, Joseph A; Wallace, Jasmine G; Cotter, Ryan P; Jolliffe, Alyssa M; Clark, Karl J; Schimmenti, Lisa A

Lineage labeling with zebrafish hand2 Cre and CreERT2 recombinase CRISPR knock-ins.

利用斑马鱼 hand2 Cre 和 CreERT2 重组酶 CRISPR 敲入进行谱系标记

Ming Zhitao, Liu Fang, Moran Hannah R, Lalonde Robert L, Adams Megan, Restrepo Nicole K, Joshi Parnal, Ekker Stephen C, Clark Karl J, Friedberg Iddo, Sumanas Saulius, Yin Chunyue, Mosimann Christian, Essner Jeffrey J, McGrail Maura

Unconstrained Precision Mitochondrial Genome Editing with αDdCBEs

利用αDdCBEs进行无约束的精准线粒体基因组编辑

Castillo, Santiago R; Simone, Brandon W; Clark, Karl J; Devaux, Patricia; Ekker, Stephen C

Bi-allelic variants in HMGCR cause an autosomal-recessive progressive limb-girdle muscular dystrophy

HMGCR基因的双等位基因变异会导致常染色体隐性遗传的进行性肢带型肌营养不良症。

Morales-Rosado, Joel A; Schwab, Tanya L; Macklin-Mantia, Sarah K; Foley, A Reghan; Pinto E Vairo, Filippo; Pehlivan, Davut; Donkervoort, Sandra; Rosenfeld, Jill A; Boyum, Grace E; Hu, Ying; Cong, Anh T Q; Lotze, Timothy E; Mohila, Carrie A; Saade, Dimah; Bharucha-Goebel, Diana; Chao, Katherine R; Grunseich, Christopher; Bruels, Christine C; Littel, Hannah R; Estrella, Elicia A; Pais, Lynn; Kang, Peter B; Zimmermann, Michael T; Lupski, James R; Lee, Brendan; Schellenberg, Matthew J; Clark, Karl J; Wierenga, Klaas J; Bönnemann, Carsten G; Klee, Eric W

Mitochondrial Base Editing: Recent Advances towards Therapeutic Opportunities

线粒体碱基编辑:治疗机遇的最新进展

Kar, Bibekananda; Castillo, Santiago R; Sabharwal, Ankit; Clark, Karl J; Ekker, Stephen C

A Primer Genetic Toolkit for Exploring Mitochondrial Biology and Disease Using Zebrafish

利用斑马鱼探索线粒体生物学和疾病的入门级遗传工具包

Sabharwal, Ankit; Campbell, Jarryd M; Schwab, Tanya L; WareJoncas, Zachary; Wishman, Mark D; Ata, Hirotaka; Liu, Wiebin; Ichino, Noriko; Hunter, Danielle E; Bergren, Jake D; Urban, Mark D; Urban, Rhianna M; Holmberg, Shannon R; Kar, Bibekananda; Cook, Alex; Ding, Yonghe; Xu, Xiaolei; Clark, Karl J; Ekker, Stephen C

The NIH Somatic Cell Genome Editing program

美国国立卫生研究院体细胞基因组编辑计划

Saha, Krishanu; Sontheimer, Erik J; Brooks, P J; Dwinell, Melinda R; Gersbach, Charles A; Liu, David R; Murray, Stephen A; Tsai, Shengdar Q; Wilson, Ross C; Anderson, Daniel G; Asokan, Aravind; Banfield, Jillian F; Bankiewicz, Krystof S; Bao, Gang; Bulte, Jeff W M; Bursac, Nenad; Campbell, Jarryd M; Carlson, Daniel F; Chaikof, Elliot L; Chen, Zheng-Yi; Cheng, R Holland; Clark, Karl J; Curiel, David T; Dahlman, James E; Deverman, Benjamin E; Dickinson, Mary E; Doudna, Jennifer A; Ekker, Stephen C; Emborg, Marina E; Feng, Guoping; Freedman, Benjamin S; Gamm, David M; Gao, Guangping; Ghiran, Ionita C; Glazer, Peter M; Gong, Shaoqin; Heaney, Jason D; Hennebold, Jon D; Hinson, John T; Khvorova, Anastasia; Kiani, Samira; Lagor, William R; Lam, Kit S; Leong, Kam W; Levine, Jon E; Lewis, Jennifer A; Lutz, Cathleen M; Ly, Danith H; Maragh, Samantha; McCray, Paul B Jr; McDevitt, Todd C; Mirochnitchenko, Oleg; Morizane, Ryuji; Murthy, Niren; Prather, Randall S; Ronald, John A; Roy, Subhojit; Roy, Sushmita; Sabbisetti, Venkata; Saltzman, W Mark; Santangelo, Philip J; Segal, David J; Shimoyama, Mary; Skala, Melissa C; Tarantal, Alice F; Tilton, John C; Truskey, George A; Vandsburger, Moriel; Watts, Jonathan K; Wells, Kevin D; Wolfe, Scot A; Xu, Qiaobing; Xue, Wen; Yi, Guohua; Zhou, Jiangbing

The FusX TALE Base Editor (FusXTBE) for Rapid Mitochondrial DNA Programming of Human Cells In Vitro and Zebrafish Disease Models In Vivo

用于体外快速对人类细胞和体内斑马鱼疾病模型进行线粒体DNA编程的FusX TALE碱基编辑器(FusXTBE)

Sabharwal, Ankit; Kar, Bibekananda; Restrepo-Castillo, Santiago; Holmberg, Shannon R; Mathew, Neal D; Kendall, Benjamin Luke; Cotter, Ryan P; WareJoncas, Zachary; Seiler, Christoph; Nakamaru-Ogiso, Eiko; Clark, Karl J; Ekker, Stephen C

Endogenous zebrafish proneural Cre drivers generated by CRISPR/Cas9 short homology directed targeted integration.

利用 CRISPR/Cas9 短同源定向靶向整合技术生成的内源性斑马鱼促神经 Cre 驱动因子

Almeida Maira P, Welker Jordan M, Siddiqui Sahiba, Luiken Jon, Ekker Stephen C, Clark Karl J, Essner Jeffrey J, McGrail Maura

De novo variants of NR4A2 are associated with neurodevelopmental disorder and epilepsy

NR4A2基因的新生变异与神经发育障碍和癫痫有关。

Singh, Sakshi; Gupta, Aditi; Zech, Michael; Sigafoos, Ashley N; Clark, Karl J; Dincer, Yasemin; Wagner, Matias; Humberson, Jennifer B; Green, Sarah; van Gassen, Koen; Brandt, Tracy; Schnur, Rhonda E; Millan, Francisca; Si, Yue; Mall, Volker; Winkelmann, Juliane; Gavrilova, Ralitza H; Klee, Eric W; Engleman, Kendra; Safina, Nicole P; Slaugh, Rachel; Bryant, Emily M; Tan, Wen-Hann; Granadillo, Jorge; Misra, Sunita N; Schaefer, G Bradley; Towner, Shelley; Brilstra, Eva H; Koeleman, Bobby P C