日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

R-loop editing by DNA cytosine deaminase APOBEC3B modulates the activity of oestrogen receptor enhancers.

DNA胞嘧啶脱氨酶APOBEC3B对R环的编辑调节雌激素受体增强子的活性。

Zhang Chi, Lu Yu-Jing, Chen Bingjie, Bai Zhiyan, Zeng Qiaoxi, Hervieu Alexia, Licciardello Marco P, Mitsopoulos Konstantinos, Al-Lazikani Bissan, Tortorici Marcello, Rossanese Olivia W, Workman Paul, Clarke Paul A

Human DEAH-box helicase 8 regulates HSF1-mediated stress response and cancer-associated pre-mRNA splicing in tumour cells.

人类 DEAH 盒解旋酶 8 调节 HSF1 介导的应激反应和肿瘤细胞中与癌症相关的 pre-mRNA 剪接。

Tall Jennifer R, Te Poele Robert, Vasile Alexandra, Ramagiri Pradeep, Campbell James, Davies Caitlin R, Powers Marissa V, Roe Toby, Sankaran Deivendran, Wang Hannah, Mitsopoulos Konstantinos, Al-Lazikani Bissan, van Montfort Rob L M, de Billy Emmanuel, Workman Paul, Clarke Paul A

Structural insights into human brachyury DNA recognition and discovery of progressible binders for cancer therapy

对人类短尾蛋白DNA识别的结构性见解以及用于癌症治疗的新型结合剂的发现

Newman, Joseph A; Gavard, Angeline E; Imprachim, Nergis; Aitkenhead, Hazel; Sheppard, Hadley E; Te Poele, Robert; Clarke, Paul A; Hossain, Mohammad Anwar; Temme, Louisa; Oh, Hans J; Wells, Carrow I; Davis-Gilbert, Zachary W; Workman, Paul; Gileadi, Opher; Drewry, David H

Advances in understanding and targeting eIF4E activity

对 eIF4E 活性的理解和靶向治疗的进展

Kunji, Edmund R S; Mavridou, Vasiliki; King, Martin S; Cimadamore-Werthein, Camila; Jaiquel Baron, Stephany; Jones, Scott A; King, Alannah C; Springett, Roger; Chand, Deepak; Palmer, Shane M; Lacabanne, Denis; Tavoulari, Sotiria; Ruprecht, Jonathan J; D'Agostino, Sabrina; Davies, Caitlin; Powers, Marissa V; Clarke, Paul A

Mediator Kinase Inhibitor Selectivity and Activity in Colorectal Cancer

介导激酶抑制剂在结直肠癌中的选择性和活性

Ortiz-Ruiz, Maria J; Popoola, Olajumoke; Mitsopoulos, Konstantinos; Te-Poele, Robert; Samant, Rahul S; Box, Gary; Court, Will; Brandon, Alexis De Haven; Gowan, Sharon; Mallinger, Aurelie; Roe, Toby; Swabey, Kate; Valenti, Melanie; Al-Lazikani, Bissan; Blagg, Julian; Esdar, Christina; Schiemann, Kai; Wienke, Dirk; Eccles, Suzanne A; Workman, Paul; Clarke, Paul A

Characterisation of APOBEC3B-Mediated RNA editing in breast cancer cells reveals regulatory roles of NEAT1 and MALAT1 lncRNAs

对APOBEC3B介导的RNA编辑在乳腺癌细胞中的表征揭示了NEAT1和MALAT1 lncRNA的调控作用

Zhang, Chi; Lu, Yu-Jing; Wang, Mei; Chen, Bingjie; Xiong, Feifei; Mitsopoulos, Costas; Rossanese, Olivia; Li, Xiuling; Clarke, Paul A

HSF1 Pathway Inhibitor Clinical Candidate (CCT361814/NXP800) Developed from a Phenotypic Screen as a Potential Treatment for Refractory Ovarian Cancer and Other Malignancies

HSF1通路抑制剂临床候选药物(CCT361814/NXP800)基于表型筛选开发,有望用于治疗难治性卵巢癌和其他恶性肿瘤。

Pasqua, A Elisa; Sharp, Swee Y; Chessum, Nicola E A; Hayes, Angela; Pellegrino, Loredana; Tucker, Michael J; Miah, Asadh; Wilding, Birgit; Evans, Lindsay E; Rye, Carl S; Mok, N Yi; Liu, Manjuan; Henley, Alan T; Gowan, Sharon; De Billy, Emmanuel; Te Poele, Robert; Powers, Marissa; Eccles, Suzanne A; Clarke, Paul A; Raynaud, Florence I; Workman, Paul; Jones, Keith; Cheeseman, Matthew D

Evolution of kinase polypharmacology across HSP90 drug discovery.

HSP90药物发现过程中激酶多药理学的演变

Antolin Albert A, Clarke Paul A, Collins Ian, Workman Paul, Al-Lazikani Bissan

Catalytic Gels for a Prebiotically Relevant Asymmetric Aldol Reaction in Water: From Organocatalyst Design to Hydrogel Discovery and Back Again

用于水中益生元相关不对称羟醛缩合反应的催化凝胶:从有机催化剂设计到水凝胶发现再回到有机催化剂设计

Hawkins, Kirsten; Patterson, Anna K; Clarke, Paul A; Smith, David K

The kinase polypharmacology landscape of clinical PARP inhibitors

临床PARP抑制剂的激酶多药理学概况

Antolin, Albert A; Ameratunga, Malaka; Banerji, Udai; Clarke, Paul A; Workman, Paul; Al-Lazikani, Bissan