日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Metformin to Improve Walking Performance in Lower Extremity Peripheral Artery Disease: The PERMET Randomized Clinical Trial

二甲双胍改善下肢周围动脉疾病患者步行能力:PERMET随机临床试验

McDermott, Mary M; Domanchuk, Kathryn J; Tian, Lu; Zhao, Lihui; Zhang, Dongxue; Bazzano, Lydia; Berceli, Scott; Criqui, Michael H; Ferrucci, Luigi; Guralnik, Jack M; Leeuwenburgh, Christiaan; Ho, Karen J; Ismaeel, Ahmed; Kibbe, Melina R; Korcarz, Claudia; Kosmac, Kate; Lloyd-Jones, Donald; Peterson, Charlotte A; Stein, James H; Sufit, Robert; Wilkins, John; Polonsky, Tamar S

Wnt-associated DKK3 in keratinocytes mediates radiation-induced hyperplasia, dermatitis and skin fibrosis.

角质形成细胞中的 Wnt 相关 DKK3 介导辐射引起的增生、皮炎和皮肤纤维化。

Li Li, Lopez Perez Ramon, Shehzad Khuram, Jennemann Richard, Schmidt Claudia, Walle Thomas, Tietz-Dahlfuß Alexandra, Grimm Elisabeth, Kraske Joscha A, Häring Peter, Barayeu Uladzimir, Dick Tobias P, Ye Luxi, Braun Stephan A, Hertl Michael, Worzfeld Thomas, Wiech Thorsten, Ji Huihui, Su Jing, Schneeweiss Jonathan M, Liu Muzi, Kommoss Katharina, Heikenwälder Matthias, Zou Bingwen, Mücklich Sabrina, Steinbrink Kerstin, Raker Verena K, Wu Wenjun, Noessner Elfriede, Gröne Hermann-Josef, Nelson Peter J, Sandhoff Roger, Huber Peter E

Shared and specific blood biomarkers for multimorbidity

多种疾病的共有和特异性血液生物标志物

Ornago, Alice Margherita; Gregorio, Caterina; Triolo, Federico; Moore, Ann Zenobia; Marengoni, Alessandra; Beridze, Giorgi; Grande, Giulia; Bellelli, Giuseppe; Dale, Matilda; Fredolini, Claudia; Ferrucci, Luigi; Fratiglioni, Laura; Calderón-Larrañaga, Amaia; Vetrano, Davide Liborio

A chiral fermionic valve driven by quantum geometry

由量子几何驱动的手性费米子阀

Dixit, Anvesh; Sivakumar, Pranava K; Manna, Kaustuv; Felser, Claudia; Parkin, Stuart S P

Androgen activity in the male embryonic hindbrain drives lethal PFA ependymoma.

雄性胚胎后脑中的雄激素活性会引发致命的 PFA 室管膜瘤。

Zhang Jiao, Ong Winnie, Rasnitsyn Alexandra, Gonzalez Ricardo Daniel, Lopez Gutierrez Rodrigo, Balin Polina, Saadeldin Amr, Wu Xiaochong, Vladoiu Maria C, Santa-Maria Lopez Vicente, Gonzalez-Salinas Fernando, Yadav Navneesh, Mohanakrishnan Dinesh, Boosi Narayana Rao Kannan, Mooli Raja Gopal Reddy, Najem Hinda, Pacheco Sebastian, Kharas Kaitlin, Richman Cory, Przelicki David, Wang Evan Y, Su Haipeng, Curry Rachel Naomi, Yang Runze, Kameda-Smith Michelle Masayo, Livingston Bryn, Scott David, Luo Zaili, Xia Mingyang, Abeysundara Namal, Erickson Anders W, Mankahla Ncedile, Hu Lucas ZhongMing, Pan Chu, Suarez Raul, Huang Ning, Wu Yihao, Wang Hao, Douglas Tajana, Pallota Jonelle, Hébert Steven, Ng Karen, Mantione Krystin, Whetstone Heather, Maan Hassaan, Lakkis Hussein, Lee Juyeun, Ramakrishnan Sadeesh K, Pei Yanxin, Tang Yujie, Lin Frank Y, Aldave Guillermo, Gallo Marco, Friedlander Robert M, Notta Faiyaz, Donovan Laura K, Chintagumpala Murali, Wang Bo, Li Yun, De Carvalho Daniel D, Zhang Zhaolei, Mao Ying, Hua Wei, Eberhart Charles, Lucas Calixto-Hope G, Venneti Sriram, Sorensen Poul H, Delaidelli Alberto, Li Hao, Zhou Wenhao, Kirk Jason, Tang Dean G, Jiang Tao, Liu Hailong, Lathia Justin D, Suzuki Hiromichi, Rich Jeremy N, Stein Lincoln D, Jabado Nada, Ramaswamy Vijay, Lu Q Richard, Heimberger Amy B, Daniels Craig, Michealraj Kulandaimanuvel Antony, Kleinman Claudia L, Taylor Michael D

Ligand-specific activation trajectories dictate GPCR signalling in cells.

配体特异性激活轨迹决定细胞内的 GPCR 信号传导。

Thomas Romy, Jacoby Pauline S, De Faveri Chiara, Derieux Cécile, Liebing Aenne-Dorothea, Melkes Barbora, Martini Hans-Joachim, Bermúdez Marcel, Stäubert Claudia, Lohse Martin J, Coin Irene, Bock Andreas

Termination of the integrated stress response.

终止整合应激反应。

De Miguel Claudia, Thorkelsson Sigurdur R, Fatalska Agnieszka, Hodgson George, Dalglish Maximillian, Wang Chao, Bertolotti Anne

Safety and efficacy of crenezumab in cognitively unimpaired carriers of the PSEN1(Glu280Ala) mutation at risk for autosomal-dominant Alzheimer's disease in Colombia (API ADAD Colombia Trial): a phase 2, randomised, double-blind, placebo-controlled trial

在哥伦比亚,一项针对认知功能正常的、携带PSEN1(Glu280Ala)突变且有常染色体显性遗传阿尔茨海默病风险的人群的克雷尼珠单抗安全性和有效性研究(API ADAD Colombia试验):一项2期随机、双盲、安慰剂对照试验

Tariot, Pierre N; Lopera, Francisco S; Ríos-Romenets, Silvia; Sink, Kaycee M; Giraldo-Chica, Margarita; Acosta-Baena, Natalia; Villegas, Gustavo; Espinosa, Alejandro; Castaño, Marisol Londoño; Muñoz, Claudia; Ospina, Paula; Bocanegra, Yamile; Tirado, Victoria; Henao, Eliana; Cardona, Eugenia; Luna, Ernesto; Lopez, Hugo; Sánchez, Gregorio; Collazos, Mario Muñoz; Alvarez, Sergio; Aguillón, David; Hu, Nan; Clayton, David; Bittner, Tobias; Schneider, Andres; Dolton, Michael; Poon, Victor; Nguyen, Jonas; Thomas, Ronald G; Schneider, Lon S; Chen, Kewei; Su, Yi; Alexander, Robert C; Quiroz, Yakeel T; Cai, Yuqi; Xu, Yi Ran; Ostaszewski, Beth; Selkoe, Dennis J; Ashton, Nicholas J; Denkinger, Marisa N; Jakimovich, Laura J; Doody, Rachelle S; Langbaum, Jessica B; Reiman, Eric M

Extended Endocrine Therapy Following 5 Years of Adjuvant Luteinizing Hormone-Releasing Hormone Agonist in Premenopausal Patients With Node-Positive, Hormone Receptor-Positive Breast Cancer: A Cohort Study

绝经前淋巴结阳性、激素受体阳性乳腺癌患者接受5年辅助促黄体生成素释放激素激动剂治疗后延长内分泌治疗:一项队列研究

Valenza, Carmine; Zheng, Yue; Milano, Monica; Trapani, Dario; Giordano, Elisa; Guidi, Lorenzo; Berton Giachetti, Pier Paolo Maria; Boldrini, Laura; Castellano, Grazia; Katrini, Jalissa; Malagutti, Bianca; Antonarelli, Gabriele; Conforti, Fabio; Pagan, Eleonora; Bagnardi, Vincenzo; Kirkner, Gregory J; Sangalli, Claudia; Dibble, Kate E; Colleoni, Marco; Regan, Meredith M; Munzone, Elisabetta; Curigliano, Giuseppe; Partridge, Ann H

An oncogenic KRAS-driven secretome involving TNFα promotes niche preparation prior to pancreatic cancer onset.

致癌的 KRAS 驱动的分泌组(涉及 TNFα)促进胰腺癌发生前的微环境准备。

Allgöwer Chantal, Mulaw Medhanie A, Nagai James, Wiedenmann Sandra, Ringel Elena Anne, Ferrara Benedetta, Piemonti Lorenzo, Maulana Tengku Ibrahim, Ferreira Luisa T, Flinders Adam, Teufel Claudia, Reichardt Leon, Lopatta Paul B, Srinivasan Dharini, Lahusen Anton, Seufferlein Thomas, Gaisa Nadine Therese, Beck Annika, Lindenmayer Jessica, Melzer Michael K, Zimmer Eleni, Roger Elodie, Heller Sandra, Löhr J-Mathias, Liebau Stefan, Loskill Peter, Lin Yuan-Na, Camisa Paolo Riccardo, Jorgensen Claus, Crippa Stefano, Meier Matthias, Hohwieler Meike, Costa Ivan G, Breunig Markus, Kleger Alexander