日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

An Enzyme with High Catalytic Proficiency Utilizes Distal Site Substrate Binding Energy to Stabilize the Closed State but at the Expense of Substrate Inhibition

一种具有高催化能力的酶利用远端位点底物结合能来稳定闭合状态,但代价是底物抑制

Angus J Robertson, F Aaron Cruz-Navarrete, Henry P Wood, Nikita Vekaria, Andrea M Hounslow, Claudine Bisson, Matthew J Cliff, Nicola J Baxter, Jonathan P Waltho

Peptidic boronic acids are potent cell-permeable inhibitors of the malaria parasite egress serine protease SUB1

肽硼酸是疟原虫出口丝氨酸蛋白酶 SUB1 的强效细胞通透性抑制剂

Elina Lidumniece, Chrislaine Withers-Martinez, Fiona Hackett, Christine R Collins, Abigail J Perrin, Konstantinos Koussis, Claudine Bisson, Michael J Blackman, Aigars Jirgensons

An exported kinase family mediates species-specific erythrocyte remodelling and virulence in human malaria

输出激酶家族介导人类疟疾中物种特异性红细胞重塑和毒力

Heledd Davies #, Hugo Belda #, Malgorzata Broncel, Xingda Ye, Claudine Bisson, Viola Introini, Dominique Dorin-Semblat, Jean-Philippe Semblat, Marta Tibúrcio, Benoit Gamain, Myrsini Kaforou, Moritz Treeck

High-resolution crystal structure of human asparagine synthetase enables analysis of inhibitor binding and selectivity

人类天冬酰胺合成酶的高分辨率晶体结构可以分析抑制剂的结合和选择性

Wen Zhu, Ashish Radadiya, Claudine Bisson, Sabine Wenzel, Brian E Nordin, Francisco Martínez-Márquez, Tsuyoshi Imasaki, Svetlana E Sedelnikova, Adriana Coricello, Patrick Baumann, Alexandria H Berry, Tyzoon K Nomanbhoy, John W Kozarich, Yi Jin, David W Rice, Yuichiro Takagi, Nigel G J Richards

A protease cascade regulates release of the human malaria parasite Plasmodium falciparum from host red blood cells

蛋白酶级联调节人类疟原虫恶性疟原虫从宿主红细胞中释放

James A Thomas, Michele S Y Tan, Claudine Bisson, Aaron Borg, Trishant R Umrekar, Fiona Hackett, Victoria L Hale, Gema Vizcay-Barrena, Roland A Fleck, Ambrosius P Snijders, Helen R Saibil, Michael J Blackman