日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

UCM-A86 is a selective positive allosteric modulator of GluN1/GluN3 NMDA receptors

UCM-A86 是 GluN1/GluN3 NMDA 受体的选择性正向变构调节剂。

期刊:Molecular Pharmacology
影响因子:3
doi:10.1016/j.molpha.2026.100103
Benton, Avery J; Johns, Mia R; Diamant, Emil; Rouzbeh, Nirvan; Sørensen, Valdemar P; Anderson, Carly M; Secci, Davide; Zhang, Zhucheng; Rau, Andrew R; Clausen, Rasmus P; Hansen, Kasper B
信号转导
发表日期：2026
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Novel binding mode for negative allosteric NMDA receptor modulators

负变构NMDA受体调节剂的新型结合模式

期刊:Journal of General Physiology
影响因子:2.9
doi:10.1085/jgp.202513872
Lotti, James S; Syrenne, Jed T; Benton, Avery J; Al-Mousawi, Ahmad; Cornelison, Lauren E; Trolinder, Christopher J; Yi, Feng; Zhang, Zhucheng; Yates-Hansen, Cindee K; McClelland, Levi J; Bosco, James; Rau, Andrew R; Clausen, Rasmus P; Hansen, Kasper B
信号转导
发表日期：2026
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Evaluation of allosteric N-methyl-d-aspartate receptor modulation by GluN2A-selective antagonists using pharmacological equilibrium modeling

利用药理平衡模型评估GluN2A选择性拮抗剂对N-甲基-D-天冬氨酸受体的变构调节作用

期刊:Molecular Pharmacology
影响因子:3
doi:10.1124/molpharm.124.000975
Lotti, James S; Jones, Jaron; Farnsworth, Jill C; Yi, Feng; Zhao, Fabao; Menniti, Frank S; Volkmann, Robert A; Clausen, Rasmus P; Hansen, Kasper B
信号转导
发表日期：2025
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UCM-A86 is a selective positive allosteric modulator of GluN1/GluN3 NMDA receptors

UCM-A86 是 GluN1/GluN3 NMDA 受体的选择性正向变构调节剂。

期刊:
影响因子:
doi:10.1101/2025.11.14.688378
Benton, Avery J; Johns, Mia R; Diamant, Emil; Rouzbeh, Nirvan; Sørensen, Valdemar P; Anderson, Carly M; Secci, Davide; Zhang, Zhucheng; Rau, Andrew R; Clausen, Rasmus P; Hansen, Kasper B
信号转导
发表日期：2025
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In vitro ADME characterization of a very potent 3-acylamino-2-aminopropionic acid-derived GluN2C-NMDA receptor agonist and its ester prodrugs

体外 ADME 表征一种高效的 3-酰氨基-2-氨基丙酸衍生的 GluN2C-NMDA 受体激动剂及其酯类前药

期刊:Biological Chemistry
影响因子:2.4
doi:10.1515/hsz-2022-0229
Bechthold, Elena; Grey, Lucie; Diamant, Emil; Schmidt, Judith; Steigerwald, Ruben; Zhao, Fabao; Hansen, Kasper B; Bunch, Lennart; Clausen, Rasmus P; Wünsch, Bernhard
信号转导
发表日期：2023
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Discovery of (R)-2-amino-3-triazolpropanoic acid derivatives as NMDA receptor glycine site agonists with GluN2 subunit-specific activity

发现(R)-2-氨基-3-三唑丙酸衍生物作为NMDA受体甘氨酸位点激动剂，具有GluN2亚基特异性活性

期刊:Frontiers in Chemistry
影响因子:4.2
doi:10.3389/fchem.2022.1008233
Zhao, Fabao; Mazis, Georgios; Yi, Feng; Lotti, James S; Layeux, Michael S; Schultz, Eric P; Bunch, Lennart; Hansen, Kasper B; Clausen, Rasmus P
信号转导
发表日期：2022
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GHB analogs confer neuroprotection through specific interaction with the CaMKIIα hub domain

GHB类似物通过与CaMKIIα枢纽结构域的特异性相互作用发挥神经保护作用。

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2108079118
Leurs, Ulrike; Klein, Anders B; McSpadden, Ethan D; Griem-Krey, Nane; Solbak, Sara M Ø; Houlton, Josh; Villumsen, Inge S; Vogensen, Stine B; Hamborg, Louise; Gauger, Stine J; Palmelund, Line B; Larsen, Anne Sofie G; Shehata, Mohamed A; Kelstrup, Christian D; Olsen, Jesper V; Bach, Anders; Burnie, Robert O; Kerr, D Steven; Gowing, Emma K; Teurlings, Selina M W; Chi, Chris C; Gee, Christine L; Frølund, Bente; Kornum, Birgitte R; van Woerden, Geeske M; Clausen, Rasmus P; Kuriyan, John; Clarkson, Andrew N; Wellendorph, Petrine
发表日期：2021
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Pharmacological Characterization of a Betaine/GABA Transporter 1 (BGT1) Inhibitor Displaying an Unusual Biphasic Inhibition Profile and Anti-seizure Effects

甜菜碱/GABA转运体1 (BGT1) 抑制剂的药理学特征：具有不寻常的双相抑制特性和抗癫痫作用

期刊:Neurochemical Research
影响因子:3.8
doi:10.1007/s11064-020-03017-y
Lie, Maria E K; Kickinger, Stefanie; Skovgaard-Petersen, Jonas; Ecker, Gerhard F; Clausen, Rasmus P; Schousboe, Arne; White, H Steve; Wellendorph, Petrine
神经科学
癫痫
发表日期：2020
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Elucidation of fluorine's impact on pK(a) and in vitro Pgp-mediated efflux for a series of PDE9 inhibitors

阐明氟对一系列PDE9抑制剂的pK(a)和体外Pgp介导的外排的影响

期刊:Medchemcomm
影响因子:
doi:10.1039/c8md00114f
Fjelbye, Kasper; Marigo, Mauro; Clausen, Rasmus P; Jørgensen, Erling B; Christoffersen, Claus T; Juhl, Karsten
发表日期：2018
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Pharmacology and Structural Analysis of Ligand Binding to the Orthosteric Site of Glutamate-Like GluD2 Receptors

谷氨酸样GluD2受体正构位点配体结合的药理学和结构分析

期刊:Molecular Pharmacology
影响因子:3
doi:10.1124/mol.115.100909
Kristensen, Anders S; Hansen, Kasper B; Naur, Peter; Olsen, Lars; Kurtkaya, Natalie L; Dravid, Shashank M; Kvist, Trine; Yi, Feng; Pøhlsgaard, Jacob; Clausen, Rasmus P; Gajhede, Michael; Kastrup, Jette S; Traynelis, Stephen F
信号转导
发表日期：2016
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