日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

ClpC1-targeting peptide natural products differentially dysregulate the proteome of Mycobacterium tuberculosis

ClpC1靶向肽天然产物差异性地扰乱结核分枝杆菌的蛋白质组

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-026-68423-2
Barter, Isabel K; Bedding, Max J; Leodolter, Julia; Maxwell, Joshua W C; Hawkins, Paige M E; Stevens, Maxwell T; McNeil, Matthew B; Jowsey, William J; Wang, Trixie; Quan, Diana; Junker, Sabryna; Flórido, Manuela; Hesselson, Daniel; Cook, Gregory M; Clausen, Tim; Britton, Warwick J; Larance, Mark; Payne, Richard J
发表日期：2026
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Guardian ubiquitin E3 ligases target cancer-associated APOBEC3 deaminases for degradation to promote human genome integrity

守护者泛素E3连接酶靶向癌症相关的APOBEC3脱氨酶进行降解，从而促进人类基因组的完整性。

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-026-68420-5
Schwartz, Irene; Budroni, Valentina; Meyenberg, Mathilde; Hodakova, Zuzana; Hornegger, Harald; Hacker, Kathrin; Schwartz, Siegfried; Grabarczyk, Daniel B; Ehrmann, Julian F; Scinicariello, Sara; Haselbach, David; Menche, Jörg; Clausen, Tim; Karagöz, G Elif; Versteeg, Gijs A
肿瘤
APOB
肿瘤免疫
发表日期：2026
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Structural basis for substrate recruitment and catalytic ubiquitin transfer by the E2/E3 hybrid enzyme UBE2O

E2/E3 杂合酶 UBE2O 底物募集和催化泛素转移的结构基础

期刊:Journal of Biological Chemistry
影响因子:3.9
doi:10.1016/j.jbc.2025.111073
Kordic, Darja; Williams, Thomas L; Deszcz, Luiza; Ehrmann, Julian F; Arnese, Renato; Schleiffer, Alexander; Clausen, Tim; Meinhart, Anton
UBE2O
发表日期：2026
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Architecture of the UBR4 complex, a giant E4 ligase central to eukaryotic protein quality control

UBR4复合物的结构：一种在真核生物蛋白质质量控制中起核心作用的巨型E4连接酶

期刊:Science
影响因子:45.8
doi:10.1126/science.adv9309
Grabarczyk, Daniel B; Ehrmann, Julian F; Murphy, Paul; Yang, Woo Seok; Kurzbauer, Robert; Bell, Lillie E; Deszcz, Luiza; Neuhold, Jana; Schleiffer, Alexander; Shulkina, Alexandra; Lee, Juyeon; Shin, Jin Seok; Meinhart, Anton; Versteeg, Gijs A; Zavodszky, Eszter; Song, Hyun Kyu; Hegde, Ramanujan S; Clausen, Tim
发表日期：2025
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Convergence of orphan quality control pathways at a ubiquitin chain-elongating ligase.

孤儿质量控制通路在泛素链延伸连接酶处的汇合

期刊:Molecular Cell
影响因子:16.6
doi:10.1016/j.molcel.2025.01.002
Carrillo Roas Sara, Yagita Yuichi, Murphy Paul, Kurzbauer Robert, Clausen Tim, Zavodszky Eszter, Hegde Ramanujan S
表观遗传
发表日期：2025
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ATP functions as a pathogen-associated molecular pattern to activate the E3 ubiquitin ligase RNF213.

ATP 作为病原体相关分子模式，可激活 E3 泛素连接酶 RNF213

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-025-59444-4
Ahel Juraj, Balci Arda, Faas Victoria, Grabarczyk Daniel B, Harmo Roosa, Squair Daniel R, Zhang Jiazhen, Roitinger Elisabeth, Lamoliatte Frederic, Mathur Sunil, Deszcz Luiza, Bell Lillie E, Lehner Anita, Williams Thomas L, Sowar Hanna, Meinhart Anton, Wood Nicola T, Clausen Tim, Virdee Satpal, Fletcher Adam J
表观遗传
发表日期：2025
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TRIM52 maintains cellular fitness and is under tight proteolytic control by multiple giant E3 ligases.

TRIM52 维持细胞健康，并受到多种巨型 E3 连接酶的严格蛋白水解控制

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-025-59129-y
Shulkina Alexandra, Hacker Kathrin, Ehrmann Julian F, Budroni Valentina, Mandlbauer Ariane, Bock Johannes, Grabarczyk Daniel B, Edobor Genevieve, Cochella Luisa, Clausen Tim, Versteeg Gijs A
细胞生物学
发表日期：2025
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Author Correction: PARP14 and PARP9/DTX3L regulate interferon-induced ADP-ribosylation

作者更正：PARP14 和 PARP9/DTX3L 调控干扰素诱导的 ADP 核糖基化

期刊:EMBO Journal
影响因子:8.3
doi:10.1038/s44318-024-00247-6
Kar, Pulak; Chatrin, Chatrin; Đukić, Nina; Suyari, Osamu; Schuller, Marion; Zhu, Kang; Prokhorova, Evgeniia; Bigot, Nicolas; Baretić, Domagoj; Ahel, Juraj; Elsborg, Jonas Damgaard; Nielsen, Michael L; Clausen, Tim; Huet, Sébastien; Niepel, Mario; Sanyal, Sumana; Ahel, Dragana; Smith, Rebecca; Ahel, Ivan
DTX3L
信号转导
PARP1
PARP
发表日期：2024
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APPARILLO: a fully operational and autonomous staring system for LEO debris detection

APPARILLO：一套用于低地球轨道碎片探测的全功能自主凝视系统

期刊:CEAS Space Journal
影响因子:1.8
doi:10.1007/s12567-021-00380-6
Wagner, Paul; Clausen, Tim
APP
发表日期：2022
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Structural mechanism for the recognition and ubiquitination of a single nucleosome residue by Rad6-Bre1.

Rad6-Bre1识别和泛素化单个核小体残基的结构机制

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.1606863113
Gallego Laura D, Ghodgaonkar Steger Medini, Polyansky Anton A, Schubert Tobias, Zagrovic Bojan, Zheng Ning, Clausen Tim, Herzog Franz, Köhler Alwin
表观遗传
炎性小体
泛素化
发表日期：2016
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