日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A Two-Stage Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of Ec-18 in Altering the Severity and Course of Oral Mucositis Secondary to Chemoradiation Therapy for Squamous Cell Cancers of the Head and Neck

一项分两阶段进行的 II 期多中心随机双盲安慰剂对照研究,旨在评估 EC-18 在改善头颈部鳞状细胞癌放化疗继发性口腔黏膜炎的严重程度和病程方面的安全性和有效性。

Henson, Christina; Clayburgh, Daniel; Lee, Arielle; Wong, Deborah; Kudrimoti, Mahesh; Lee, Steve; Kalman, Noah; Rao, Krishna; Sohn, Ki Young; Crawford, Jeffrey; Villa, Alessandro; Sonis, Stephen

Early, precise, and safe clinical evaluation of the pharmacodynamic effects of novel agents in the intact human tumor microenvironment

在完整的人类肿瘤微环境中,对新型药物的药效学效应进行早期、精确、安全的临床评估

Gundle, Kenneth R; Rajasekaran, Karthik; Houlton, Jeffrey; Deutsch, Gary B; Ow, Thomas J; Maki, Robert G; Pang, John; Nathan, Cherie-Ann O; Clayburgh, Daniel; Newman, Jason G; Brinkmann, Elyse; Wagner, Michael J; Pollack, Seth M; Thompson, Matthew J; Li, Ryan J; Mehta, Vikas; Schiff, Bradley A; Wenig, Barry I; Swiecicki, Paul L; Tang, Alice L; Davis, Jessica L; van Zante, Annemieke; Bertout, Jessica A; Jenkins, Wendy; Turner, Atticus; Grenley, Marc; Burns, Connor; Frazier, Jason P; Merrell, Angela; Sottero, Kimberly H W; Derry, Jonathan M J; Gillespie, Kate C; Mills, Bre; Klinghoffer, Richard A

Response to Neoadjuvant Targeted Therapy in Operable Head and Neck Cancer Confers Survival Benefit

可手术头颈癌患者接受新辅助靶向治疗后,生存获益显著

Mascarella, Marco A; Olonisakin, Tolani F; Rumde, Purva; Vendra, Varun; Nance, Melonie A; Kim, Seungwon; Kubik, Mark W; Sridharan, Shaum S; Ferris, Robert L; Fenton, Moon J; Clayburgh, Daniel R; Ohr, James P; Joyce, Sonali C; Sen, Malabika; Herman, James G; Grandis, Jennifer R; Zandberg, Dan P; Duvvuri, Umamaheswar

Trackable Intratumor Microdosing and Spatial Profiling Provide Early Insights into Activity of Investigational Agents in the Intact Tumor Microenvironment

可追踪的肿瘤内微剂量和空间分析可帮助早期洞察完整肿瘤微环境中试验药物的活性

Jonathan M J Derry, Connor Burns, Jason P Frazier, Emily Beirne, Marc Grenley, Christopher C DuFort, Emily Killingbeck, Michael Leon, Claire Williams, Mark Gregory, Jeffrey Houlton, Daniel Clayburgh, Paul Swiecicki, Dennis Huszar, Allison Berger, Richard A Klinghoffer

Functional proteomics of patient derived head and neck squamous cell carcinoma cells reveal novel applications of trametinib

患者来源的头颈部鳞状细胞癌细胞的功能蛋白质组学揭示了曲美替尼的新应用

Myles Vigoda, Chase Mathieson, Nathaniel Evans, Carolyn Hale, Jennifer Jennings, Olivia Lucero, Sophia Jeng, Daniel Bottomly, Daniel Clayburgh, Peter Andersen, Ryan Li, Daniel Petrisor, Jeffrey W Tyner, Shannon McWeeney, Molly Kulesz-Martin

Chemoradiation therapy alters the PD-L1 score in locoregional recurrent squamous cell carcinomas of the head and neck

放化疗会改变头颈部局部复发性鳞状细胞癌的PD-L1评分

Park, Brian J; Mattox, Austin K; Clayburgh, Daniel; Patel, Mihir; Bell, R Bryan; Yueh, Bevan; Leidner, Rom; Xiao, Hong; Couey, Marcus; Li, Shiting; Qin, Tingting; Sartor, Maureen A; Cairns, Belinda; MacDonough, Tracy; Halliwill, Kyle; Deschler, Daniel; Lin, Derrick T; Faquin, William C; Sadow, Peter M; Pai, Sara I

Establishment and Validation of Pre-Therapy Cervical Vertebrae Muscle Quantification as a Prognostic Marker of Sarcopenia in Patients With Head and Neck Cancer

建立和验证治疗前颈椎肌肉定量作为头颈癌患者肌少症预后标志物

Olson, Brennan; Edwards, Jared; Degnin, Catherine; Santucci, Nicole; Buncke, Michelle; Hu, Jeffrey; Chen, Yiyi; Fuller, Clifton D; Geltzeiler, Mathew; Grossberg, Aaron J; Clayburgh, Daniel

Spatial Profiles of Intratumoral PD-1(+) Helper T Cells Predict Prognosis in Head and Neck Squamous Cell Carcinoma

肿瘤内PD-1(+)辅助性T细胞的空间分布可预测头颈部鳞状细胞癌的预后

Yoshimura, Kanako; Tsujikawa, Takahiro; Mitsuda, Junichi; Ogi, Hiroshi; Saburi, Sumiyo; Ohmura, Gaku; Arai, Akihito; Shibata, Saya; Thibault, Guillaume; Chang, Young Hwan; Clayburgh, Daniel R; Yasukawa, Satoru; Miyagawa-Hayashino, Aya; Konishi, Eiichi; Itoh, Kyoko; Coussens, Lisa M; Hirano, Shigeru

Risk of Suicidal Self-directed Violence Among US Veteran Survivors of Head and Neck Cancer

美国头颈癌退伍军人幸存者自杀性自残行为的风险

Nugent, Shannon M; Morasco, Benjamin J; Handley, Robert; Clayburgh, Daniel; Hooker, Elizabeth R; Ganzini, Linda; Knight, Sara J; Chen, Jason I; Sullivan, Donald R; Slatore, Christopher G

Relevance of circulating hybrid cells as a non-invasive biomarker for myriad solid tumors

循环杂交细胞作为多种实体瘤的非侵入性生物标志物的意义

Dietz, Matthew S; Sutton, Thomas L; Walker, Brett S; Gast, Charles E; Zarour, Luai; Sengupta, Sidharth K; Swain, John R; Eng, Jennifer; Parappilly, Michael; Limbach, Kristen; Sattler, Ariana; Burlingame, Erik; Chin, Yuki; Gower, Austin; Mira, Jose L Montoya; Sapre, Ajay; Chiu, Yu-Jui; Clayburgh, Daniel R; Pommier, SuEllen J; Cetnar, Jeremy P; Fischer, Jared M; Jaboin, Jerry J; Pommier, Rodney F; Sheppard, Brett C; Tsikitis, V Liana; Skalet, Alison H; Mayo, Skye C; Lopez, Charles D; Gray, Joe W; Mills, Gordon B; Mitri, Zahi; Chang, Young Hwan; Chin, Koei; Wong, Melissa H