日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Analgesia and peripheral c-fiber modulation by selective Na v 1.8 inhibition in rhesus.

选择性抑制 Na v 1.8 对恒河猴镇痛和外周 C 纤维调节的影响

Vardigan Joshua D, Pall Parul S, McDevitt Dillon S, Huang ChienJung, Clements Michelle K, Li Yuxing, Kraus Richard L, Breslin Michael J, Bungard Christopher J, Nemenov Mikhail I, Klukinov Mikhail, Burgey Chritopher S, Layton Mark E, Stachel Shawn J, Lange Henry S, Savitz Alan T, Santarelli Vincent P, Henze Darrell A, Uslaner Jason M

Humanized Na(V)1.8 rats overcome cross-species potency shifts in developing novel Na(V)1.8 inhibitors.

人源化 Na(V)1.8 大鼠克服了开发新型 Na(V)1.8 抑制剂时跨物种效力变化的问题

McDevitt Dillon S, Vardigan Joshua D, Zhou Xiaoping, Rosahl Thomas W, Zhou Heather, Price Eric A, Clements Michelle K, Li Yuxing, Varghese Nissi, Krasowska-Zoladek Alicja, Stachel Shawn J, Breslin Michael J, Burgey Christopher S, Kraus Richard L, Pall Parul S, Henze Darrell A, Santarelli Vincent P

2-Aminopyridines as Potent and Selective Na(v)1.8 Inhibitors Exhibiting Efficacy in a Nonhuman Primate Pain Model

2-氨基吡啶类化合物作为强效且选择性的Na(v)1.8抑制剂,在非人灵长类动物疼痛模型中显示出疗效。

Breslin, Michael J; Schubert, Jeffrey W; Wang, Deping; Huang, Chienjung; Clements, Michelle K; Li, Yuxing; Zhou, Xiaoping; Vardigan, Joshua D; Kraus, Richard L; Santarelli, Vincent P; Uslaner, Jason M; Coleman, Paul J; Stachel, Shawn J

Association of respiratory failure with inhibition of NaV1.6 in the phrenic nerve

呼吸衰竭与膈神经中NaV1.6抑制有关

Klein, Rebecca M; Layton, Mark E; Regan, Hillary; Regan, Christopher P; Li, Yuxing; Filzen, Tracey; Cato, Matt; Clements, Michelle K; Wang, Jixin; Sanoja, Raul; Greshock, Thomas J; Roecker, Anthony J; Pero, Joseph E; Kim, Ron; Burgey, Christopher; John, Christopher T; Wang, Ying-Hong; Bhandari, Neetesh; Struyk, Arie; Kraus, Richard L; Henze, Darrell A; Houghton, Andrea K

Allosteric modulation of group III metabotropic glutamate receptor 4: a potential approach to Parkinson's disease treatment

III型代谢型谷氨酸受体4的变构调节:一种治疗帕金森病的潜在方法

Marino, Michael J; Williams, David L Jr; O'Brien, Julie A; Valenti, Ornella; McDonald, Terrence P; Clements, Michelle K; Wang, Ruiping; DiLella, Anthony G; Hess, J Fred; Kinney, Gene G; Conn, P Jeffrey