文献库，生知库 | 链接生命科学的每一步

David T Asuzu ,Reinier Alvarez ,Patrick A Fletcher ,Debjani Mandal ,Kory Johnson ,Weiwei Wu ,Abdel Elkahloun ,Paul Clavijo ,Clint Allen ,Dragan Maric ,Abhik Ray-Chaudhury ,Sharika Rajan ,Zied Abdullaev ,Diana Nwokoye ,Kenneth Aldape ,Lynnette K Nieman ,Constantine Stratakis ,Stanko S Stojilkovic ,Prashant Chittiboina

凋亡

细胞生物学

免疫/内分泌

表观遗传

发表日期：2022

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Inhibiting WEE1 and IKK-RELA Crosstalk Overcomes TNFα Resistance in Head and Neck Cancers

抑制 WEE1 和 IKK-RELA 串扰可克服头颈癌中的 TNFα 耐药性

期刊:Molecular Cancer Research

影响因子:4.1

doi:10.1158/1541-7786.MCR-21-0624

Zhengbo Hu, Ramya Viswanathan, Hui Cheng, Jianghong Chen, Xinping Yang, Angel Huynh, Paul Clavijo, Yi An, Yvette Robbins, Christopher Silvin, Clint Allen, Pinar Ormanoglu, Scott Martin, Shaleeka Cornelius, Anthony Saleh, Zhong Chen, Carter Van Waes #, Ethan L Morgan #

Chimeric antigen receptor engineered NK cellular immunotherapy overcomes the selection of T-cell escape variant cancer cells

嵌合抗原受体工程化 NK 细胞免疫疗法克服了 T 细胞逃逸变异癌细胞的选择

期刊:Journal for ImmunoTherapy of Cancer

影响因子:10.3

doi:10.1136/jitc-2020-002128

Maxwell Y Lee, Yvette Robbins, Cem Sievers, Jay Friedman, Houssein Abdul Sater, Paul E Clavijo, Nancy Judd, Edward Tsong, Chris Silvin, Patrick Soon-Shiong, Michelle R Padget, Jeffrey Schlom, James Hodge, Christian Hinrichs, Clint Allen

Dual PD-L1 and TGF-b blockade in patients with recurrent respiratory papillomatosis

复发性呼吸道乳头状瘤病患者的 PD-L1 和 TGF-b 双重阻断

期刊:Journal for ImmunoTherapy of Cancer

影响因子:10.3

doi:10.1136/jitc-2021-003113

Yvette Robbins, Jay Friedman, Paul E Clavijo, Cem Sievers, Ke Bai, Renee N Donahue, Jeffrey Schlom, Andrew Sinkoe, Christian S Hinrichs, Clint Allen, Houssein Abdul Sater, James L Gulley, Scott Norberg

Inhibition of MDSC Trafficking with SX-682, a CXCR1/2 Inhibitor, Enhances NK-Cell Immunotherapy in Head and Neck Cancer Models

使用 CXCR1/2 抑制剂 SX-682 抑制 MDSC 运输可增强头颈癌模型中的 NK 细胞免疫疗法

期刊:Clinical Cancer Research

影响因子:10

doi:10.1158/1078-0432.CCR-19-2625

Sarah Greene, Yvette Robbins, Wojciech K Mydlarz, Angel P Huynh, Nicole C Schmitt, Jay Friedman, Lucas A Horn, Claudia Palena, Jeffrey Schlom, Dean Y Maeda, John A Zebala, Paul E Clavijo, Clint Allen

Dual Antagonist of cIAP/XIAP ASTX660 Sensitizes HPV- and HPV+ Head and Neck Cancers to TNFα, TRAIL, and Radiation Therapy

cIAP/XIAP双重拮抗剂ASTX660可增强HPV阴性和HPV阳性头颈癌对TNFα、TRAIL和放射疗法的敏感性

期刊:Clinical Cancer Research

影响因子:10

doi:10.1158/1078-0432.CCR-18-3802

Roy Xiao ，Yi An ，Wenda Ye ，Adeeb Derakhshan ，Hui Cheng ，Xinping Yang ，Clint Allen ，Zhong Chen ，Nicole C Schmitt ，Carter Van Waes

Enhancing direct cytotoxicity and response to immune checkpoint blockade following ionizing radiation with Wee1 kinase inhibition

通过抑制 Wee1 激酶增强电离辐射后的直接细胞毒性和对免疫检查点阻断的反应

期刊:Oncoimmunology

影响因子:

doi:10.1080/2162402X.2019.1638207

Priya Patel, Lily Sun, Yvette Robbins, Paul E Clavijo, Jay Friedman, Christopher Silvin, Carter Van Waes, John Cook, James Mitchell, Clint Allen

Anti-PD-L1 Efficacy Can Be Enhanced by Inhibition of Myeloid-Derived Suppressor Cells with a Selective Inhibitor of PI3Kδ/γ

通过使用 PI3Kδ/γ 选择性抑制剂抑制髓系抑制细胞，可以增强抗 PD-L1 疗效

期刊:Cancer Research

影响因子:12.5

doi:10.1158/0008-5472.CAN-16-2534

Ruth J Davis, Ellen C Moore, Paul E Clavijo, Jay Friedman, Harrison Cash, Zhong Chen, Chris Silvin, Carter Van Waes, Clint Allen

Established T Cell-Inflamed Tumors Rejected after Adaptive Resistance Was Reversed by Combination STING Activation and PD-1 Pathway Blockade

通过联合激活STING和阻断PD-1通路逆转适应性耐药后已形成的T细胞炎症肿瘤被排斥

期刊:Cancer Immunology Research

影响因子:8.1

doi:10.1158/2326-6066.CIR-16-0104

Ellen Moore，Paul E Clavijo，Ruth Davis，Harrison Cash，Carter Van Waes，Young Kim，Clint Allen

mTOR and MEK1/2 inhibition differentially modulate tumor growth and the immune microenvironment in syngeneic models of oral cavity cancer

mTOR 和 MEK1/2 抑制对口腔癌同源模型中的肿瘤生长和免疫微环境有差异的调节

期刊:Oncotarget

影响因子:

doi:10.18632/oncotarget.5063

Harrison Cash, Sujay Shah, Ellen Moore, Andria Caruso, Ravindra Uppaluri, Carter Van Waes, Clint Allen

Pituitary adenomas evade apoptosis via noxa deregulation in Cushing's disease

库欣病中垂体腺瘤通过NOXA失调逃避细胞凋亡

Inhibiting WEE1 and IKK-RELA Crosstalk Overcomes TNFα Resistance in Head and Neck Cancers

抑制 WEE1 和 IKK-RELA 串扰可克服头颈癌中的 TNFα 耐药性

Chimeric antigen receptor engineered NK cellular immunotherapy overcomes the selection of T-cell escape variant cancer cells

嵌合抗原受体工程化 NK 细胞免疫疗法克服了 T 细胞逃逸变异癌细胞的选择

Dual PD-L1 and TGF-b blockade in patients with recurrent respiratory papillomatosis

复发性呼吸道乳头状瘤病患者的 PD-L1 和 TGF-b 双重阻断

Inhibition of MDSC Trafficking with SX-682, a CXCR1/2 Inhibitor, Enhances NK-Cell Immunotherapy in Head and Neck Cancer Models

使用 CXCR1/2 抑制剂 SX-682 抑制 MDSC 运输可增强头颈癌模型中的 NK 细胞免疫疗法

Dual Antagonist of cIAP/XIAP ASTX660 Sensitizes HPV- and HPV+ Head and Neck Cancers to TNFα, TRAIL, and Radiation Therapy

cIAP/XIAP双重拮抗剂ASTX660可增强HPV阴性和HPV阳性头颈癌对TNFα、TRAIL和放射疗法的敏感性

Enhancing direct cytotoxicity and response to immune checkpoint blockade following ionizing radiation with Wee1 kinase inhibition

通过抑制 Wee1 激酶增强电离辐射后的直接细胞毒性和对免疫检查点阻断的反应

Anti-PD-L1 Efficacy Can Be Enhanced by Inhibition of Myeloid-Derived Suppressor Cells with a Selective Inhibitor of PI3Kδ/γ

通过使用 PI3Kδ/γ 选择性抑制剂抑制髓系抑制细胞，可以增强抗 PD-L1 疗效

Established T Cell-Inflamed Tumors Rejected after Adaptive Resistance Was Reversed by Combination STING Activation and PD-1 Pathway Blockade

通过联合激活STING和阻断PD-1通路逆转适应性耐药后已形成的T细胞炎症肿瘤被排斥

mTOR and MEK1/2 inhibition differentially modulate tumor growth and the immune microenvironment in syngeneic models of oral cavity cancer

mTOR 和 MEK1/2 抑制对口腔癌同源模型中的肿瘤生长和免疫微环境有差异的调节